The free oxygen radicals test (FORT) to assess circulating oxidative stress in patients with acute myocardial infarction

Lorgis, Luc; Zeller, Marianne; Dentan, Gilles; Sicard, Pierre; Richard, Carole; Buffet, Philippe; L’Huillier, Isabelle; Beer, Jean‐Claude; Cottin, Yves; Rochette, Luc; Vergely, Catherine

doi:10.1016/j.atherosclerosis.2010.09.018

Cited by 42 publications

(33 citation statements)

References 28 publications

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“…24 In a study by Lorgis et al, NT-proBNP was a significant determinant of cardiovascular mortality in patients older than 54 years but not in the younger. 25 This is in accordance to our results where only 9/71 (13%) were younger than 54 years and none of these patients died during follow-up. In summary, these data and the data from our study suggest that natriuretic peptides such as BNP or NT-proBNP are strong markers of cardiovascular and overall outcome and may outperform the other prognostic parameters TIMI risk score or Killip class.…”

Section: Prognostic Value Of Nt-probnp In Patients With Acssupporting

confidence: 82%

Prognostic Value of N-Terminal pro-B-Type Natriuretic Peptide in Patients With Acute Coronary Syndromes Undergoing Left Main Percutaneous Coronary Intervention

Jaberg¹,

Toggweiler²,

Puck³

et al. 2011

Circ J

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Background: Patients undergoing acute left main (LM) coronary artery revascularization have a high mortality and natriuretic peptides such as N-terminal pro-B-type (NT-proBNP) have been shown to have prognostic value in patients with acute coronary syndromes. The present study looked at the prognostic value of NT-proBNP in these patients. Methods and Results:We studied all consecutive patients undergoing acute LM coronary artery percutaneous coronary intervention between January 2005 and December 2008 in whom NT-proBNP was measured (n=71). We analyzed the clinical characteristics and the short- and long-term outcomes in relation to NT-proBNP level at admission. Median NT-proBNP was 1,364 ng/L, ranging from 46 to 70,000 ng/L. NT-proBNP was elevated in 63 (89%) patients and was ≥1,000 ng/L in 42 (59%). Log NT-proBNP (hazard ratio [HR] 3.51, 95% confidence interval [CI] 1.55-7.97, P=0.003) and left ventricular ejection fraction (HR 0.95, 95%CI 0.91-0.99, P=0.007) were predictors for all-cause mortality. Log NT-proBNP was the only independent significant predictor of cardiovascular mortality. In-hospital mortality was 0% for patients with NT-proBNP <1,000, but 17% for those with NT-proBNP ≥1,000 (P= 0.036). Conclusions:NT-proBNP is a strong predictor of outcome in patients undergoing acute LM coronary artery stenting. Mortality in such patients is high, but those with NT-proBNP <1,000 ng/L may have a favorable short- and longterm prognosis. Further research, including a larger patient population, is needed to determine the optimal cut-off value for NT-proBNP in patients undergoing acute LM coronary artery intervention. (Circ J 2011; 75: 2648 - 2653

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Section: Prognostic Value Of Nt-probnp In Patients With Acssupporting

confidence: 82%

Prognostic Value of N-Terminal pro-B-Type Natriuretic Peptide in Patients With Acute Coronary Syndromes Undergoing Left Main Percutaneous Coronary Intervention

Jaberg¹,

Toggweiler²,

Puck³

et al. 2011

Circ J

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“…To date, only 2 studies have investigated the prognostic value of NPs, specifically in the elderly population. 30,31 Drewniak et al 30 studied 161 patients aged 79 ± 8 years who were admitted with either STEMI or non-STEMI. NT-proBNP levels were measured during hospital admission and repeated at 6 months.…”

Section: Bnp and Nt-probnp In Older Patients With Acs: Current Evidencementioning

confidence: 99%

B‐type Natriuretic Peptides in Acute Coronary Syndromes: Implications in an Aging Population

Krim

Vivo

Lemos³

2012

Clinical Cardiology

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B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP) are increasingly recognized as prognostic markers in patients with acute coronary syndrome (ACS). The need for novel and more effective tools for risk assessment cannot be more emphasized than in older patients with ACS given their atypical presentation, multiple comorbidities, and higher risk for mortality and morbidity. Accurate interpretation of B-type NP values in older patients with ACS, however, may be confounded by several aging-related physiologic changes. Advanced age, reduction in body mass, and kidney function and anemia have been associated with higher BNP and NT-proBNP concentrations, and may create challenges with interpreting NP levels in the elderly. This review highlights the need to better understand the physiology of BNP and NT-proBNP in older individuals and their prognostic value in older patients with ACS. IntroductionThe prognostic role of B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP) in acute coronary syndromes (ACS) remains the subject of vigorous investigation reflecting the growing interest in improving risk stratification strategies for affected patients. While a compelling body of evidence demonstrates that these biomarkers independently predict adverse outcomes, a few issues of uncertainty limit their routine use in clinical decision making. One is the question of whether existing evidence can be extrapolated to the older population. This is an important issue as approximately 82% of deaths from coronary artery disease (CAD) occur in individuals age 65 or older. 1 Fundamental to examining the value of BNP and NT-proBNP in older persons with CAD is identifying aging-related factors that may influence their levels. This review summarizes current literature describing the value of these biomarkers in older patients with ACS. The relationship of BNP and NT-proBNP with advanced age and its associated physiologic alterations is also reviewed.

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“…NO is an essential modulator of biological systems, including the cardiovascular system, and plays a critical role in cardioprotection. Additionally, cardioprotection is related to the levels of different types of NOS [27,28]. It is widely accepted that iNOS induces apoptosis but that cNOS inhibits apoptosis [29,30,31].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Millettia Pulchra Flavonoids on Myocardial Ischemia In Vitro and In Vivo

Huang

Zhang²,

et al. 2015

Cell Physiol Biochem

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Background: Previous studies have demonstrated that Millettia pulchra flavonoids (MPF) exhibit protective effects on myocardial ischemia reperfusion injury (MI/RI) in isolated rat hearts and show anti-oxidative, anti-hypoxic and anti-stress properties. Methods: In this study, the cardioprotective effects of MPF on myocardial ischemia and its underlying mechanisms were investigated by a hypoxia/ reoxygenation (H/R) injury model in vitro and a rat MI/RI model in vivo. Results: We found that the lactate dehydrogenase (LDH) and inducible nitric oxide synthase (iNOS) activities were decreased in the MPF pretreatment group, whereas the activities of constructional nitric oxide synthase (cNOS), total nitric oxide synthase (tNOS), Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase were significantly increased. In addition, the cardiocytes were denser in the MPF groups than in the control group. The mortality rate and apoptosis rate of cardiocytes were significantly decreased. Furthermore, pretreatment with MPF in vivo significantly improved the hemodynamics, decreased malondialdehyde (MDA) abundance, increased the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and decreased the expression of the Bax protein and ratio Bax/Bc1-2 ration. Conclusions: These results suggest that MPF is an attractive protective substance in myocardial ischemia due to its negative effects on heart rate and ionotropy, reduction of myocardial oxidative damage and modulation of gene expression associated with apoptosis.

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The free oxygen radicals test (FORT) to assess circulating oxidative stress in patients with acute myocardial infarction

Cited by 42 publications

References 28 publications

Prognostic Value of N-Terminal pro-B-Type Natriuretic Peptide in Patients With Acute Coronary Syndromes Undergoing Left Main Percutaneous Coronary Intervention

Prognostic Value of N-Terminal pro-B-Type Natriuretic Peptide in Patients With Acute Coronary Syndromes Undergoing Left Main Percutaneous Coronary Intervention

B‐type Natriuretic Peptides in Acute Coronary Syndromes: Implications in an Aging Population

Protective Effects of Millettia Pulchra Flavonoids on Myocardial Ischemia In Vitro and In Vivo

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