The frequencies of human neutrophil alloantigens among the Japanese population

Matsuhashi, Mika; Tsuno, Nelson H.; Kawabata, Masahiro; Mishima, Yuko; Okochi, Noriko; Tozuka, Minoru; Takahashi, Koki

doi:10.1111/j.1399-0039.2012.01930.x

Cited by 28 publications

(71 citation statements)

References 30 publications

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“…The HNA‐3b/3b genotype frequency among the Zhuang population is 8.6%, which is similar to the frequencies reported in the Dong population of our study and also other Asian populations like Chinese Han, Japanese and Thai shown by previous publications (Changsri et al., ; Matsuhashi et al., ; Xia et al., ) but is significantly higher than that of African American Shown by Huvard et al. (), Brazilian as shown by Lopes et al.…”

Section: Discussionsupporting

confidence: 91%

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Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations

Liao

Jiao

et al. 2017

Int J Immunogenetics

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Individuals with the human neutrophil antigen (HNA)-3b/3b type can produce HNA-3a antibodies, which have been reported to cause severe, sometimes fatal transfusion-related acute lung injury (TRALI). Our study aimed to determine the genotype frequency of HNA-3a/3b which will be helpful to estimate the potential risk for forming anti-HNA-3a, the clinically relevant antibody linked to TRALI in two different ethnic groups of southern China. Five hundred unrelated and healthy blood donors (284 male, 216 female; 300 Zhuangs, 200 Dongs) from the Guangxi Zhuang Autonomous Region were simultaneously typed for the HNA-3 allele using a polymerase chain reaction sequence-based typing (PCR-SBT) method. Genotype frequencies of HNA-3a/3a, HNA-3a/3b and HNA-3b/3b were 51.7%, 39.7% and 8.6% in the Zhuang population, and 44.0%, 49.0% and 7.0% in the Dong population, respectively. Homozygous HNA-3b/3b genotype frequency among the Zhuang population (8.6%) was significantly higher than previously reported in African Americans (0.4%), Brazilians (3.6%) and English Caucasians (2.9%) (p < .05). And the HNA-3b/3b genotype frequency among the Dong population was higher than African Americans (0.4%) (p < .05). This study showed Chinese Zhuang and Dong populations possessed a higher frequency of HNA-3b/3b genotype, suggesting that they may be at greater risk for developing anti-HNA-3a alloantibodies that may cause severe cases of TRALI. A molecular-based identification of the HNA-3b/3b genotype in all multiparous female blood donors was suggested to reduce the risk of TRALI following plasma and whole blood allogeneic transfusions.

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Section: Discussionsupporting

confidence: 91%

“…(), the Japanese populations as reported by Matsuhashi et al. () and also the Thai population (Nathalang, Intharanut, Siriphanthong, & Leetrakool, ); However, the 457C>T substitution was found in German population as reported by Flesch et al. () and the African American blood donors as shown by Huvard et al.…”

Section: Discussionmentioning

confidence: 82%

Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations

Liao

Jiao

et al. 2017

Int J Immunogenetics

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“…In this study, we developed a new method, EGIFA, to detect anti‐HNA‐1a, ‐1b, and ‐2 antibodies simultaneously. We focused on anti‐HNA‐1a, ‐1b, and ‐2 antibodies because the majority of anti‐HNA antibodies detected in Japanese patients with immune neutropenias are anti‐HNA‐1a, ‐1b, or ‐2 based on the frequency of HNA types in Japan . To evaluate the reliability of EGIFA, we compared the results of EGIFA with the results obtained from several conventional methods.…”

Section: Discussionmentioning

confidence: 99%

Anti‐human neutrophil antigen‐1a, ‐1b, and ‐2 antibodies in neonates and children with immune neutropenias analyzed by extracted granulocyte antigen immunofluorescence assay

et al. 2017

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BACKGROUND Anti‐human neutrophil antigen (HNA) antibodies have been implicated in the development of neonatal alloimmune neutropenia (NAN) and autoimmune neutropenia (AIN). There are many conventional assay methods that detect anti‐HNA antibodies. However, a method to measure multiple samples and detect several anti‐HNA antibodies simultaneously is needed. STUDY DESIGN AND METHODS We developed a new method, the extracted granulocyte antigen immunofluorescence assay (EGIFA), to analyze anti‐HNA‐1a, ‐1b, and ‐2 antibodies in sera. The results obtained by EGIFA were evaluated in comparison with those from several standard assay methods. Anti‐HNA antibodies in serum samples from nine familial cases with suspected NAN (n = 19) and children with suspected AIN (n = 88) were also measured by EGIFA. RESULTS The evaluation of nine serum samples with anti‐HNA antibodies suggested that EGIFA demonstrated equivalent specificity and superior sensitivity to monoclonal antibody–specific immobilization of granulocyte antigens and had comparable sensitivity to the granulocyte indirect immunofluorescence test. EGIFA successfully detected anti‐HNA‐1a or ‐1b antibodies in seven of nine familial cases with suspected NAN. EGIFA detected anti‐HNA antibodies in 40.9% of children with suspected AIN. Among them, isolated anti‐HNA‐1a or ‐1b antibody was detected in 4.5 or 12.5% of children, respectively, and anti‐HNA‐2 antibody was identified in 3.4% of children. The 30.8% (16 of 52) of children negative for anti‐HNA antibody by EGIFA were positive for anti‐HLA antibody. CONCLUSION EGIFA facilitated the measurement of anti‐HNA‐1a, ‐1b, and/or ‐2 antibodies in sera. The prompt measurement of anti‐HNA antibodies will improve the diagnosis and clinical management of patients with suspected NAN or AIN.

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“…Among Africans and Caucasians, HNA‐1b is more frequent than HNA‐1a. In contrast, in Asians and Amerindians, HNA‐1a is more frequent than HNA‐1b . HNA‐1c is most often found among Africans (20%–30%) and Caucasians (5–10%), while it is very rare in Asians (<1/500) .…”

Section: Introductionmentioning

confidence: 91%

Re‐evaluation of HNA‐1 antibodies for their reactivity to different recombinant variants of FcγRIIIb

Nishizawa

Yasui

Amakishi

et al. 2015

ISBT Science Series

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Background and Objectives The Fcgamma receptor IIIb (FccRIIIb) carries the human neutrophil antigen (HNA)-1 system. The three FCGR3B alleles encode four antigens: one allele encodes HNA-1a, and two alleles encode two antigens each, HNA-1b and HNA-1d and HNA-1b and HNA-1c, respectively. Several other nonsynonymous substitutions have also been reported. Little is known about the properties of HNA-1d antibodies because HNA-1d was recently discovered, and HNA-1d antibodies have been reported only in a couple of cases. These findings raise the possibility that the polymorphisms in the HNA-1 system and spectrum of the specificity of resulting antibodies are more complex than previously thought. We address this possibility in this work. Materials and MethodsSeveral HNA-1 antibodies, which had been classified as HNA-1a or HNA-1b before HNA-1d was discovered, were re-evaluated for their reactivity to different recombinant variants of FccRIIIb. ResultsThe HNA-1a antibody, but not the reference HNA-1a antibody, crossreacted to HNA-1d. Further, nucleotide replacement in FCGR3B alleles *02 at 193G?A (AA position 54 E?K) resulted in the disappearance of HNA-1d, but not HNA-1b, antigenicity. ConclusionThe HNA-1 system may be more complex than previously understood.

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The frequencies of human neutrophil alloantigens among the Japanese population

Cited by 28 publications

References 30 publications

Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations

Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations

Anti‐human neutrophil antigen‐1a, ‐1b, and ‐2 antibodies in neonates and children with immune neutropenias analyzed by extracted granulocyte antigen immunofluorescence assay

Re‐evaluation of HNA‐1 antibodies for their reactivity to different recombinant variants of FcγRIIIb

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