The Frequencies of the Serum Amyloid A2 Alleles in Healthy (Turkish, Azerbaijani, and Kazakh) Populations

Abstract

The Amyloid A1 ( AA1 ) and A2 ( AA2 ) proteins, which result from proteolytic cleavage of the Serum Amyloid A1 ( SAA1 ) and A2 ( SAA2 ) proteins, are major protein components of the Amyloid A deposits found in secondary amyloidosis. This study determines frequency of serum amyloid A2 alleles ( α , β ) in healthy Turkish, Azerbaijani, and Kazakh subjects. Two hundred Turkish, sixty-five Azerbaijani and sixty-five Kazakh healthy individuals were studied by previously described the PCR-RFLP methods. Our data revealed that the frequencies of the α and β alleles at the SAA2 locus in the Turkish healthy population were different when compared to those in Azerbaijani and Kazakh healthy populations ( P = 0.014 and 0.02), respectively. In contrast, the difference between α and β alleles at the SAA2 locus was not different in both Kazakh and Azerbaijani healthy populations ( P = 0.882). ş HUMAN GENETICS* The text was submitted by the authors in English.Coding sequence SAA2 α , β SAA2 forward primer SAA2 reverse primer Intron 3 Genomic sequence Exon 3 Exon 4 ∆ ∆ Fig. 1. Schematic description of the positions of the primers for the PCR amplification.

Serum Amyloid A Stimulates PKR Expression and HMGB1 Release Possibly through TLR4/RAGE Receptors

“…The SAA2s differ from each other only at position 71 (H versus R), but differ from SAA1 at seven to eight other positions, indicating a possible polymorphism (69). Indeed, the frequencies of the α and β alleles at the SAA2 locus varied among different populations (for example, the Turkish versus the Azerbaijan and Kazakh) (70). At present, it is not yet known why human SAA was only detected in a subset of septic patients.…”