The Frequency of Carcinoma and Intraepithelial Neoplasia of the Prostate in Young Male Patients

Sakr, Wael; Haas, Gabriel P.; Cassin, Barbara; Pontes, J. Edson; Crissman, John D.

doi:10.1016/s0022-5347(17)35487-3

Cited by 616 publications

(307 citation statements)

References 23 publications

Supporting

Mentioning

278

Contrasting

Unclassified

Order By: Relevance

“…This view is comparable with the frequent presence of subclinical tumours in prostate cancer, which has been demonstrated on autopsy material. 7 The implications of a high presence of small latent tumours in the population are considerable, both for the individual and for society. When such tumours are detected, a substantial number of subjects will be unnecessarily diagnosed with cancer.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Increased incidence of invasive breast cancer after the introduction of service screening with mammography in Sweden

Jonsson

Johansson

Lenner

2005

Intl Journal of Cancer

View full text Add to dashboard Cite

Screening with mammography has been shown to substantially reduce mortality from breast cancer. The incidence of invasive cancer will increase as screening starts, and it is desirable that it gradually returns to the same level as before screening. Age-specific incidence of invasive breast cancer in 11 Swedish counties, including 463,000 women aged 40-74 years, was analysed before and after the start of service screening with mammography. Incidence, as observed on average during 12.8 years from screening start, was compared to expected incidence based on the incidence during a 15-year period preceding screening start. The height of the incidence peak during the first screening round was increasing with increasing age, compatible with the accumulation in the population of slowly growing tumours by age. All analysed age groups showed an increased ratio between observed stabilised incidence 7-14 years after screening start and expected incidence. When relative risks were adjusted for lead time, the estimates were 1.54 (95% confidence interval [CI] 1.33-1.79) and 1.21 (95% CI 1.04-1.41) for the age groups 50-59 and 60-69 years, respectively. In the age groups 40-49 and 70-74, no change was observed. The findings were further confirmed by the observation of a disappearance in the screened population of the notch in the increasing trend of age-specific breast cancer incidence for the ages after menopause. This notch could indicate hormone-related retardation in tumour growth around menopause. It appears that many of these clinically insignificant, retarded tumours are detected with screening mammography. ' 2005 Wiley-Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A corresponding phenomenon is well known in prostate cancer from studies on autopsy material. 7 The presence of latent cancers has been debated in breast cancer, but studies addressing this issue have been few. 8,9 Particularly, the follow-up after start of screening has hitherto been too short in many materials to allow valid conclusions.…”

mentioning

confidence: 99%

Increased incidence of invasive breast cancer after the introduction of service screening with mammography in Sweden

Jonsson

Johansson

Lenner

2005

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…For example, pre-neoplastic PIN lesions can be identified in a substantial number (9%) of men aged 20 -29, and asymptomatic histologic cancers and PIN lesions are reported to be present in 27 and 20% of men aged 30 -39, respectively (Sakr et al, 1993). By contrast, only 0.01% of men aged less than 40 will be clinically diagnosed with prostate cancer (Jemal et al, 2007).…”

Section: Clinical Implications and Future Directions For Investigationmentioning

confidence: 99%

“…Autopsy studies designed to assess subclinical disease in different age cohorts report substantially higher rates of cancer incidence that parallel the age-associated increases in clinical diagnoses. For example, 27% of men aged 30 -39 and 34% of men aged 40 -49 harbour foci of adenocarcinoma in the prostate (Sakr et al, 1993). In fact, advancing age is consistently the greatest risk factor for the development of prostate cancer across racial and ethnic groups.…”

mentioning

confidence: 99%

Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

Dean

Nelson

2008

Br J Cancer

View full text Add to dashboard Cite

Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.

show abstract

“…29,30 The incidence and extent of PIN appear to increase with patient age (Table 1). [31][32][33] An autopsy study of step-sectioned whole mount prostates from older men showed that the prevalence of PIN in prostates with cancer increased with age, predating the onset of carcinoma by more than 5 years. 33 A similar study of young men revealed that PIN is first seen in men in their 20s and 30s (9 and 22% frequency, respectively), and precedes the onset of carcinoma by more than 10 years.…”

Section: Epidemiology Of Pinmentioning

confidence: 99%

High-grade prostatic intraepithelial neoplasia

2004

View full text Add to dashboard Cite

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method of detection is biopsy; PIN does not significantly elevate serum prostate-specific antigen (PSA) concentration or its derivatives and cannot be detected by current imaging techniques, including ultrasound. Most patients with PIN will develop carcinoma within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype, which are similar to cancer rather than normal prostatic epithelium, indicating impairment of cell differentiation with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention.

show abstract

The Frequency of Carcinoma and Intraepithelial Neoplasia of the Prostate in Young Male Patients

Cited by 616 publications

References 23 publications

Increased incidence of invasive breast cancer after the introduction of service screening with mammography in Sweden

Increased incidence of invasive breast cancer after the introduction of service screening with mammography in Sweden

Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

High-grade prostatic intraepithelial neoplasia

Contact Info

Product

Resources

About