The Frequency of Epileptiform Discharges in Celiac Disease

Işıkay, Sedat; Kocamaz, Halil; Sezer, Sadettin; Özkars, Mehmet Yaşar; Işıkay, Nurgül; Filik, Bülent; Şan, Murat; Kanmaz, Alper

doi:10.1016/j.pediatrneurol.2015.02.006

Cited by 14 publications

(22 citation statements)

References 19 publications

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“…A recent study showed that 3.5-year-old children with persistently positive tTG antibodies on a gluten-containing diet were more likely to manifest behavioral problems, including anxiety, depression and aggressiveness, when compared to those with negative antibody tests (38) . The pathogenesis of the neurologic symptoms is unclear but they tend to resolve on a GFD (39)(40)(41) .…”

Section: Discussionmentioning

confidence: 99%

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Oliveira¹,

Mohan

Fagbemi

2018

Arq. Gastroenterol.

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Section: Discussionmentioning

confidence: 99%

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Oliveira¹,

Mohan

Fagbemi

2018

Arq. Gastroenterol.

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“…In the child reported here, recurrent episodes of GBS occurred several months before the development of classic gastrointestinal signs and symptoms of CD, thus highlighting the possibility that neurologic manifestations may precede gastrointestinal CD manifestations in children as well as adults. This observation has been reported in pediatric patients with headache [ 8 , 9 ], opsoclonus-myoclonus [ 10 ], recurrent optic neuritis [ 11 ], recurrent acute encephalopathy [ 12 ], status epilepticus [ 13 , 14 ], recurrent transient hemiplegia [ 15 ], cerebral venous sinus thrombosis [ 16 ], and transverse myelitis [ 17 ].…”

Section: Discussionmentioning

confidence: 60%

“…The effect of the gluten-free diet on peripheral neuropathy and other neuromuscular disorders associated with CD is unclear. In only a few reports was the gluten-free diet was effective, whereas other studies indicated the persistence and progression of neuropathy despite an adequate gluten-free diet [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Although in our patient the gluten-free diet was effective, further studies are needed to assess the effect of the gluten-free diet and immunomodulation on these disorders and to investigate the underlying mechanisms of nervous system involvement associated with gluten sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Celiac Disease Presenting with Peripheral Neuropathy in Children: A Case Report

Pacitto

Paglino

Genova

et al. 2017

IJERPH

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Background: Clinically relevant neurological manifestations in children with celiac disease (CD) are unusual, especially when they are considered as signs of the onset of the disease. In this paper, a case of Guillain-Barrè syndrome (GBS) as the first manifestation of CD in a 23-month-old child is reported. Case presentation: We describe a case of CD onset with peripheral neuropathy in a 23-month-old Bulgarian boy presenting with a sudden refusal to walk and absence of deep tendon reflexes in both lower limbs. Neurological symptoms were preceded by two months of gastrointestinal symptoms such as vomiting, abdominal distention, and clear signs of malnutrition and weight loss. When we evaluated the child six months after the onset of the symptoms, clinical and laboratory findings showed clear signs of peripheral neuropathy associated with malnutrition. Serum deamidated gliadin and tissue transglutaminase antibodies were therefore measured. The anti-gliadin levels were more than sixteen times higher than normal and the IgA anti-transglutaminase levels were four times higher than normal. Anti-endomysium antibodies were positive, and human leukocyte antigens (HLA) II typing confirmed a genetic predisposition to CD (DQ2 positive and DQ8 negative). Given the association between the clinical evidence of the disease and the results of the celiac screening tests, a diagnosis of CD was made without biopsy confirmation of the enteropathy. The child began a restricted gluten-free diet that led to complete recovery of the peripheral neuropathy, walking, reflexes, and overall improvement after three months on the diet. Conclusion: Our case underlines the rare but possible associations between CD and peripheral neuropathy in children as an onset symptom, even in the absence of gastrointestinal manifestations, thus suggesting that CD should always be considered in the differential diagnosis of peripheral neuropathy in children. A good knowledge of the extra-intestinal manifestations of CD is essential for the rapid introduction of a gluten-free diet that could be useful for the resolution of the neurological symptoms.

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“…About 10% of patients also experience neurological symptoms including ataxia, neuropathy, seizures, migraine, and vestibular dysfunction. 72 The constellation of epilepsy with occipital calcifications in association with celiac disease is well documented. The most commonly described seizure types are focal seizures, either with motor manifestations or with migraine-like qualities, such as accompanying headaches, visual illusions, vomiting, and transient amaurosis.…”

Section: Other Systemic Autoimmune Diseasesmentioning

confidence: 99%

“…9). [72][73][74] Systemic lupus erythematosus (SLE) is an autoimmune condition that affects multiple body systems, including the central nervous system in up to 75% of patients. 75 Seizures occur in 15 to 20% of patients with SLE.…”

Section: Other Systemic Autoimmune Diseasesmentioning

confidence: 99%

Electroencephalography Findings in Autoimmune and Neuroinflammation-Related Epilepsies

2018

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Autoimmune epilepsy occurs in association with localized central nervous system or systemic immune-mediated inflammation. Traditional anticonvulsant medications are frequently ineffective, and alternative approaches including immunomodulatory agents may be required. Identification of patients with autoimmune epilepsy may be challenging due to the variability of presentation and normal or nonspecific diagnostic results. Electroencephalography (EEG) features tend to include patterns of encephalopathy, generalized or focal interictal epileptiform abnormalities, or status epilepticus. Occasionally, specific EEG features may lend insight into the diagnosis. In this review article, we discuss EEG features of several suspected or proven immune-mediated pediatric epilepsies, including Rasmussen's encephalitis, idiopathic hemiconvulsion-hemiplegia syndrome, febrile infection-related epilepsy syndrome, epilepsies associated with autoantibodies to neuronal surface or intracellular antigens, and other systemic autoimmune diseases.

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The Frequency of Epileptiform Discharges in Celiac Disease

Cited by 14 publications

References 19 publications

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Celiac Disease Presenting with Peripheral Neuropathy in Children: A Case Report

Electroencephalography Findings in Autoimmune and Neuroinflammation-Related Epilepsies

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