The Frequency of Fibromyalgia Syndrome and the Quality of Life in Patients with Peritoneal Dialysis

Okumuş, Müyesser; Parpucu, H.; Kocaoğlu, Seher; Ceceli, Esma; Duranay, Murat; Borman, Pınar

doi:10.4236/ojra.2012.24017

Cited by 8 publications

(15 citation statements)

References 21 publications

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“…23 Of the 14 studies in our analysis, 2 reported fibromyalgia-FGID comorbidity rates of less than 20%. Okumus et al investigated IBS in patients with end-stage renal disease (ESRD), 52 and found that 16.7% of patients with both ESRD and fibromyalgia had IBS, compared with 7.1% of those with ESRD but without fibromyalgia. Given the known alterations to the gut microbiome in patients with renal disease, 55 the low comorbidity suggests the small patient group (n = 12 with ESRD plus fibromyalgia versus those with ESRD only n = 112 ) may underlie the non-significant difference reported.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

Erdrich

Hawrelak

Myers

et al. 2020

Therap Adv Gastroenterol

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Background: Fibromyalgia and functional gastrointestinal disorders (FGID) including irritable bowel syndrome (IBS) are common conditions presenting in clinical settings and are more prevalent in women. While the relationship between IBS and fibromyalgia has been demonstrated, a review of the prevalence of the broader group of FGID in adults with fibromyalgia has not been undertaken. The aim of this review was to systematically review the published literature, identifying the comorbidity of FGID in people with fibromyalgia, and to discuss the clinical implications, limitations of current research and areas of interest for future research Methods: Medline, Embase, CINAHL and Web of Science were searched during June 2019. Results were screened for original research articles meeting established criteria for identification of FGID in adults diagnosed with fibromyalgia. Results: A total of 14 studies involving 1340 adults with fibromyalgia, 363 healthy controls and 441 adults with other pathologies were included in this review. Only 1 of the 14 studies included surveyed the full range of FGID . Functional gut disorders were matched to Rome II criteria for reporting and comparison. In addition to increased abdominal pain and functional bloating or gas, IBS of mixed-pattern and constipation-types appear to be more prevalent than diarrhoea-predominant IBS in adults with fibromyalgia. Conclusion: This review confirms previous reports that IBS is common in people living with fibromyalgia and suggests that IBS-mixed and constipation types predominate. An association with a range of FGID other than IBS is suggested, but data are limited. Research exploring the association between fibromyalgia and functional gastrointestinal dysfunction beyond IBS are warranted.

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Section: Discussionmentioning

confidence: 99%

A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

Erdrich

Hawrelak

Myers

et al. 2020

Therap Adv Gastroenterol

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“…While rates of major depressive disorder (148/1374, 10.77%) were close to the frequency of depressive symptoms among predialysis patients (13%) attending a single renal center [ 32 ], they were lower than the reported prevalence of depressive symptoms among patients with CKD who are not on dialysis (21%-42%) [ 33 ]. The proportion of patients with fibromyalgia (199/1374, 14.48%) was higher than that previously reported in patients with CKD receiving hemodialysis (3.9%-12.2%) [ 34 - 37 ] or peritoneal dialysis (9.7%-18%) [ 38 , 39 ]. This may be due to the nature of the PLM database, where large communities for chronic conditions including fibromyalgia exist [ 17 ].…”

Section: Discussionmentioning

confidence: 59%

Characteristics, Symptom Severity, and Experiences of Patients Reporting Chronic Kidney Disease in the PatientsLikeMe Online Health Community: Retrospective and Qualitative Study

James¹,

Nyman²,

Fitz-Randolph³

et al. 2020

J Med Internet Res

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Background Chronic kidney disease (CKD) is a major global health burden, and is associated with increased adverse outcomes, poor quality of life, and substantial health care costs. While there is an increasing need to build patient-centered pathways for improving CKD management in clinical care, data in this field are scarce. Objective The aim of this study was to understand patient-reported experiences, symptoms, outcomes, and treatment journeys among patients with CKD through a retrospective and qualitative approach based on data available through PatientsLikeMe (PLM), an online community where patients can connect and share experiences. Methods Adult members (aged ≥18 years) with self-reported CKD within 30 days of enrollment, who were not on dialysis, and registered between 2011 and 2018 in the PLM community were eligible for the retrospective study. Patient demographics and disease characteristics/symptoms were collected from this retrospective data set. Qualitative data were collected prospectively through semistructured phone interviews in a subset of patients, and questions were oriented to better understand patients’ experiences with CKD and its management. Results The retrospective data set included 1848 eligible patients with CKD, and median age was 56 years. The majority of patients were female (1217/1841, 66.11%) and most were US residents (1450/1661, 87.30%). Of the patients who reported comorbidities (n=1374), the most common were type 2 diabetes (783/1374, 56.99%), hypertension (664/1374, 48.33%), hypercholesterolemia (439/1374, 31.95%), and diabetic neuropathy (376/1374, 27.37%). The most commonly reported severe or moderate symptoms in patients reporting these symptoms were fatigue (347/484, 71.7%) and pain (278/476, 58.4%). In the qualitative study, 18 eligible patients (13 females) with a median age of 60 years and who were mainly US residents were interviewed. Three key concepts were identified by patients to be important to optimal care and management: listening to patient needs, coordinating health care across providers, and managing clinical care. Conclusions This study provides a unique source of real-world information on the patient experience of CKD and its management by utilizing the PLM network. The results reveal the challenges these patients face living with an array of symptoms, and report key concepts identified by patients that can be used to further improve clinical care and management and inform future CKD studies.

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“…Two of the fourteen studies in our analysis reported fibromyalgia-FGID comorbidity rates of less than 20%. Okumus (42) investigated IBS in patients with end-stage renal disease (ESRD) and found that 16.7% of patients with both ESRD and fibromyalgia had IBS, compared to 7.1% of those without fibromyalgia. Given the known alterations to the gut microbiome in patients with renal disease (45), the low comorbidity suggests the small patient group (n = 12 with ESRD plus fibromyalgia versus those with ESRD-only n = 112 ) may underlie the non-significant difference (p-value not given).…”

Section: Discussionmentioning

confidence: 99%

“…One study set out to examine the prevalence of the range of FGIDs in fibromyalgia (41), five (20,32,34,35,39) focused on IBS. In four studies (31,33,36,40) IBS was recorded as part of a bigger research question and in the remaining four studies (30,37,38,42) IBS data was reported as a secondary not primary outcome measure. Four studies (32,34,37,38) included additional cohorts of patients with IBS; these subjects are excluded from control data presented in Table 2.…”

Section: Data Extractionmentioning

confidence: 99%

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A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

Erdrich¹

2020

Preprint

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Background Fibromyalgia and functional gastrointestinal disorders are frequently encountered in clinical settings. Common to both is significant burden on individuals and health care systems, an elusive aetiology and several comorbid conditions. While a relationship between irritable bowel syndrome and fibromyalgia has been demonstrated, a broader review of the relationship between fibromyalgia and other functional gut disorders has not been undertaken. Objectives This paper reports a systematic review of the published literature, identifying the comorbidity of functional gastrointestinal disorders in people with fibromyalgia. We discuss the clinical implications, limitations of current research, and areas of interest for future research Methods A systematic review of the databases Medline, Embase, CINAHL and Web of Science was undertaken in June 2019. Results were screened for original articles meeting strict criteria for identification of functional gastrointestinal disorders in adult subjects with fibromyalgia. ResultsFourteen articles were included investigating 1340 subjects with fibromyalgia, 363 healthy controls and 441 subjects with other pathologies. Functional gut disorders were matched to Rome II criteria for reporting and comparison. In addition to increased abdominal pain and functional bloating/gas, irritable bowel of mixed-pattern and constipation-types were more prevalent that diarrhoea-predominant irritable bowel in adults with fibromyalgia. One study reported the range of functional gastrointestinal disorders. Conclusion Existing research has focused on the relationship between irritable bowel syndrome and fibromyalgia, but sub-typing of irritable bowel syndrome is generally overlooked. A strong association with a range of functional gastrointestinal disorders is suggested. Further investigation is needed to determine the prevalence and relevance of the range of functional gastrointestinal disorders in patients with fibromyalgia.

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The Frequency of Fibromyalgia Syndrome and the Quality of Life in Patients with Peritoneal Dialysis

Cited by 8 publications

References 21 publications

A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

Characteristics, Symptom Severity, and Experiences of Patients Reporting Chronic Kidney Disease in the PatientsLikeMe Online Health Community: Retrospective and Qualitative Study

A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

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