The frequency of magnesium consumption directly influences its serum concentration and the amount of elutable bone magnesium in rats

Abstract

We investigated the influence of Mg feeding frequency on the variation in serum Mg concentration and tissue Mg levels in Mg-deficient rats. Sprague-Dawley rats, which had been fed a Mg-deficient diet for 14 d, were divided into 3 groups that were kept on 3 diets differing in their Mg content. The rats were fed 0.5-fold (Mg250 group), 1-fold (Mg500 group), or 1.5-fold (Mg750 group) the amounts of recommended Mg in their standard AIN-93G diet (Mg: 478 mg/kg diet) during the recovery period (12 d). The Mg500 and Mg750 groups were intermittently fed (Mg500, every 2 d; Mg750, every 3 d) so that their total intake of Mg during the recovery period could equal the Mg intake of the Mg250 group. The serum Mg concentrations increased in the 3 groups after feeding with a Mg-containing diet. However, serum Mg levels were only maintained within the normal range in the Mg250 group. After feeding on the Mg-deficient diet, in the intermittently fed groups, serum Mg concentrations decreased. Urinary Mg excretion was higher and Mg retention was lower in the Mg500 and Mg750 groups than in the Mg250 group. Moreover, bone Mg, especially elutable bone Mg, was lower in the Mg500 and Mg750 groups than in the Mg250 group. The elutable fraction of bone Mg correlated to the coefficient of variation of serum Mg concentration. In conclusion, for the maintenance of serum Mg concentration, it is important to increase the amount of elutable bone Mg by frequent Mg consumption.

Electrodeposition of hydroxyapatite coating on Mg‐4.0Zn‐1.0Ca‐0.6Zr alloy and in vitro evaluation of degradation, hemolysis, and cytotoxicity

“…2,3,5 Furthermore, Mg ions can promote the calcium deposition and are an essential element for bone growth. [6][7][8][9][10] Mg ions can be absorbed into apatite crystal lattices to accelerate the adhesion of bone cells to apatite and hence promote the growth of bone tissue. 11 In addition, compared with other metallic implant materials, the physical and mechanical properties of Mg, such as its density and elastic modulus, are closer to those of human bone, as summarized in Table I.…”

Dietary magnesium deficiency induces the expression of neuroinflammation‐related genes in mouse brain

“…Dietary MgD was induced by using paired feeding procedures. 13 , 14 , 15 , 16 , 17 To habituate the mice to a powdered diet, both groups were given a powdered Mg 2+ ‐containing diet ad libitum for 1 week. The mice were divided randomly into the MgD (n = 9) and control (Ctrl, n = 11) groups.…”