The Frequency of Mutations in Known Cardiomyopathy Genes Among Children With Hypertrophic Cardiomyopathy: The National Heart, Lung and Blood Institute-Funded Multicenter Pediatric Cardiomyopathy Registry Study

Clinical prediction of genotypes in hypertrophic cardiomyopathy: A systematic review

“…Morphology aside, septal thickness as a marker of severity of hypertrophy is also an independent predictor of informative testing in adults 25‐28,33 . This finding has also been tentatively reported in children 37,60 . An important source of heterogeneity in the literature are different reported classifications of septal thickness, which limits direct comparison of data.…”

“…Of those, 19 were peer‐reviewed articles and 10 were conference abstracts. Nine were not included in the systematic review but were felt to have some relevance to the topic and are referred to in the narrative [Cox et al 2006 33 ; Konno et al 2005 43 ; Kuroda et al 2002 44 ; Towe et al, 2015 54 ; Guo et al, 2017 56 ; Yang et al, 2017 58 ; Marstrand et al, 2020 60 ; Gandjbakhch et al, 2010 63 ; Tomasov et al 2014 64 ]. Due to the multitude of the predictors identified and heterogeneity of outcome measures reported, it was not practicable to undertake a meta‐analysis of the cumulative evidence.…”

“…[25][26][27][28]33 This finding has also been tentatively reported in children. 37,60 An important source of heterogeneity in the literature are different reported classifications of septal thickness, which limits direct comparison of data. Regardless of how increased thickness is defined though, a correlation is seen.…”