The frequent UCP2 −866G&gt;A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes

Andersen, Gitte; Dalgaard, Louise Torp; Justesen, Johanne Marie; Anthonsen, Stine; Nielsen, Trine; Thørner, Lise Wegner; Witte, Daniel R.; Jørgensen, Torben; Clausen, Jesper O.; Lauritzen, Torsten; Holmkvist, Johan; Hansen, Torben; Pedersen, Oluf

doi:10.1038/ijo.2012.22

Cited by 36 publications

(35 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The three commonly studied polymorphisms in the UCP2 gene are K866G/A polymorphism in the promoter region, the Ala55Val polymorphism in the exon 4 and the 45 bp insertion/deletion polymorphism in the 3 0 -UTR. These polymorphisms have been shown to be associated with various metabolic traits such as obesity (24), body fat distribution (25), resting energy expenditure (26), type 2 diabetes (10) and insulin resistance (9,27) in various populations from different ethnic backgrounds (24). However, there were also studies that failed to show an association between these polymorphisms and metabolic traits (8,28,29).…”

Section: Discussionmentioning

confidence: 95%

“…Polymorphisms within the UCP2 gene have been shown to be associated with various metabolic traits such as obesity (8,9) and type 2 diabetes (10,11). Although the effects of these polymorphisms on UCP2 function are still unclear, it could be hypothesised that the loss-of-function polymorphisms are likely to contribute to type 2 diabetes as a result of lower hepatic glucose uptake (12).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study

Vimaleswaran

Cavadino

Verweij

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

Background and objective: Given the role of uncoupling protein 2 (UCP2) in the accumulation of fat in the hepatocytes and in the enhancement of protective mechanisms in acute ethanol intake, we hypothesised that UCP2 polymorphisms are likely to cause liver disease through their interactions with obesity and alcohol intake. To test this hypothesis, we investigated the interaction between tagging polymorphisms in the UCP2 gene (rs2306819, rs599277 and rs659366), alcohol intake and obesity traits such as BMI and waist circumference (WC) on alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in a large meta-analysis of data sets from three populations (nZ20 242). Design and methods: The study populations included the Northern Finland Birth Cohort 1966 (nZ4996), Netherlands Study of Depression and Anxiety (nZ1883) and LifeLines Cohort Study (nZ13 363). Interactions between the polymorphisms and obesity and alcohol intake on dichotomised ALT and GGT levels were assessed using logistic regression and the likelihood ratio test. Results: In the meta-analysis of the three cohorts, none of the three UCP2 polymorphisms were associated with GGT or ALT levels. There was no evidence for interaction between the polymorphisms and alcohol intake on GGT and ALT levels. In contrast, the association of WC and BMI with GGT levels varied by rs659366 genotype (P interaction Z0.03 and 0.007, respectively; adjusted for age, gender, high alcohol intake, diabetes, hypertension and serum lipid concentrations).

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study

Vimaleswaran

Cavadino

Verweij

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Andersen et al . [13] performed a meta-analysis of 8 studies that analyzed the association between the UCP2- 886G/A polymorphism and obesity. In agreement with our data, they reported an association between the UCP2- 866A allele and protection for obesity in Europeans.…”

Section: Discussionmentioning

confidence: 99%

“…In agreement with this data, Andersen et al . [13] published a meta-analysis showing an association between the UCP2- 866G/A polymorphism and obesity in subjects of European descent. Until this date, no meta-analysis evaluated the association of UCP polymorphisms with body mass index (BMI) variability.…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability

et al. 2014

View full text Add to dashboard Cite

BackgroundThe relationship between uncoupling protein (UCP) 1–3 polymorphisms and susceptibility to obesity has been investigated in several genetic studies. However, the impact of these polymorphisms on obesity is still under debate, with contradictory results being reported. Until this date, no meta-analysis evaluated the association of UCP polymorphisms with body mass index (BMI) variability. Thus, this paper describe a meta-analysis conducted to evaluate if the -3826A/G (UCP1); -866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3) polymorphisms are associated with BMI changes.MethodsA literature search was run to identify all studies that investigated associations between UCP1-3 polymorphisms and BMI. Weighted mean differences (WMD) were calculated for different inheritance models.ResultsFifty-six studies were eligible for inclusion in the meta-analysis. Meta-analysis results showed that UCP2 55Val/Val genotype was associated with increased BMI in Europeans [Random Effect Model (REM) WMD 0.81, 95% CI 0.20, 1.41]. Moreover, the UCP2 Ins allele and UCP3-55T/T genotype were associated with increased BMI in Asians [REM WMD 0.46, 95% CI 0.09, 0.83 and Fixed Effect Model (FEM) WMD 1.63, 95% CI 0.25, 3.01]. However, a decreased BMI mean was observed for the UCP2-866 A allele in Europeans under a dominant model of inheritance (REM WMD −0.18, 95% CI −0.35, −0.01). There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences.ConclusionsThe meta-analysis detected a significant association between the UCP2-866G/A, Ins/Del, Ala55Val and UCP3-55C/T polymorphisms and BMI mean differences.

show abstract

“…This study has shown that the -866G-allele was associated with elevated fasting serum insulin levels and insulin resistance (HOMA index) and decreased insulin sensitivity in Danish subjects (Andersen et al, 2012). Furthermore, in a study performed with a Spanish group of 193 obese children and adolescents and 170 controls, Ochoa et al reported that the -55C>T (rs1800849) polymorphism of the UCP3 gene directly associated with higher fasting insulin levels and insulin resistance in heterozygous subjects from the control group.…”

Section: Impact Of Genetic Polymorphisms On Insulin Resistance 53mentioning

confidence: 98%

Impact of Genetic Polymorphisms on Insulin Resistance

Kömürcü-Bayrak¹

2012

Insulin Resistance

View full text Add to dashboard Cite

The frequent UCP2 −866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes

Abstract: The UCP2 -866G-allele is associated with decreased insulin sensitivity in Danish subjects and is associated with obesity in a combined meta-analysis.

Cited by 36 publications

References 61 publications

Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study

Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study

Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability

Impact of Genetic Polymorphisms on Insulin Resistance

Contact Info

Product

Resources

About