The Friedel-Crafts Isopropylation of Benzo[b]thiophene<sup>1</sup>

Bedell, S. F.; Spaeth, Earl C.; Bobbitt, James M.

doi:10.1021/jo01053a027

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Preparation Of 2-isopropylthiophene (I A)1

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1977

2022

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Cited by 11 publications

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“…After filtration and concentration of the solution by distillation at atmospheric pressure, pure (I a) was finally obtained by distillation under vacuum (33 °C/6 Pa) with 50 % recovery. GC-MS [44] and 1 H NMR [45] data were in agreement with those reported in the literature.…”

Section: Preparation Of 2-isopropylthiophene (I A)supporting

confidence: 90%

Sustainable Synthesis of Aryl and Heteroaryl Aldehydes

Paganelli

Tassini

Piccolo³

2022

ChemistrySelect

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Aromatic aldehydes are important intermediates for the synthesis of valuable fine and specialty chemicals and many procedures for their preparation have been developed but, nowadays, most of these synthetic methods require large amounts of reagents and multiple steps, with production of wastes. In this paper, we focused on the synthesis of some (hetero)aromatic aldehydes, used either as industrial flavor/fragrances of commercial interest, such as Heliotropine®, or as key intermediates for the preparation of some APIs and of other fragrances such as Lioral® and Helional®, by reductive carbonylation of halo derivative precursors. In order to carry out an easier and more applicable process, hydrogen donors, instead of gaseous flammable and explosive hydrogen, and recyclable phosphine free low metal content catalysts, were employed.

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Section: Preparation Of 2-isopropylthiophene (I A)supporting

confidence: 90%