The Frontal Behavioural Inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer's disease

Abstract

The objective was to evaluate the construct validity of the Italian version of the Frontal Behavioural Inventory (FBI) and its usefulness in the differential diagnosis of dementias. Standard criteria were used in the clinical diagnosis of dementias in 83 patients and 33 agematched healthy volunteers. The FBI scale was translated from English into Italian language and back-translated. Cronbach's alpha, inter-rater and test-retest reliability, FBI convergent validity and discriminant analysis were calculated. FBI profile was compared between patients affected by frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). The FBI showed a high internal consistency and inter-rater reliability and it distinguished normal behavioural conditions from those presented in FTLD or AD. An 86.8% diagnostic accuracy was calculated by the discriminant analysis, selecting only age at disease onset and FBI, and particularly distinguishing behavioural variants within the FTLD spectrum. FTLD patients showed a characteristic behavioural profile. The FBI might be a reliable and useful diagnostic tool for dementias in clinical practice.

Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus

“…Although patient's subjective complaints were still limited to difficulties in recognizing familiar faces, his caregivers reported increasingly frequent episodes of social inadequacy, impulsivity, aggressive behaviour and disinhibition. The most evident personality changes with respect to the first evaluation reported by patient's son at the FBI were in the disinhibition subscale (restlessness, irritability, excessive jocularity, impulsivity, aggression, hyperorality, hoarding); the total FBI score (32/72) was above the cutoff score thought to identify FTD patients (28.6; Alberici et al, 2007). Neurological examination was still normal.…”

“…was alert, cooperative and well oriented; his language was fluent and flawless. The patient was aware of his problems and described them in detail, but his relatives referred some early personality changes, with instances of social inadequacy (e.g.,: excessive or inappropriate jokes; childish behaviour); the total score on Frontal Behavioural Inventory (FBI; Alberici et al, 2007), administered to patient's son, was 12/72, i.e., below the cut-off point (28.6) cortex 56 (2014) 111e120 discriminating frontotemporal lobe degeneration from other dementias.…”

Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD

“…Behavioral and psychiatric disturbances were evaluated by Neuropsychiatry Inventory (NPI) (Cummings et al, 1994), and Frontal Behavioral Inventory (FBI, Part A and B) (Alberici et al, 2007).…”

Empathy and emotion recognition in semantic dementia: A case report

“…The FBI is a 24-item scale, composed of two subscales for negative (FBI-A) or positive behaviors (FBI-B). The patient showed clear pathological behavioral changes due to the disease (raw score of the Italian version of FBI = 36; Alberici et al, 2007). In particular, she showed apathy, indifference, disorganization, inattention, logopenia and semantic anomia (FBI-A) as well as irritability, impulsivity, aggression and hyperorality (FBI-B).…”