The frontal space measurement in euploid and aneuploid pregnancies at 11–13 weeks' gestation

Yazdi, B.; Riefler, Peter; Fischmüller, Kristina; Sonek, Jiri; Hoopmann, Markus; Kagan, Karl Oliver

doi:10.1002/pd.4205

Cited by 9 publications

(13 citation statements)

References 23 publications

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“…The measurement of PFSR proved to be challenging: incorrect placement of the MM line of only a few tenths of a millimeter has a large impact on the measured angle and consequently on the measurement of d2. In spite of a recent adaptation of the PFSR to facilitate its measurement in the first trimester, its detection rate for trisomies remained still about half of that in the second and third trimesters [18].…”

Section: Discussionmentioning

confidence: 99%

Prenasal Thickness, Prefrontal Space Ratio and Other Facial Profile Markers in First-Trimester Fetuses with Aneuploidies, Cleft Palate, and Micrognathia

et al. 2016

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Objective: To investigate the feasibility and reproducibility of the prenasal thickness (PNT)/nasal bone length (NBL) ratio, maxilla-nasion-mandible (MNM) angle, facial profile line, profile line distance, and prefrontal space ratio (PFSR) in the first trimester of pregnancy, develop normal ranges, and evaluate these markers in abnormal fetuses. Methods: All measurements were performed on stored images by two operators. Feasibility, interoperator agreement, and prediction intervals were calculated for all measurements. Results: Feasibility was the highest for the NBL (74.3-79.7%) and the MNM angle (75.7-79.05%). Correlation was good for the NBL, the PNT, and the MNM angle (intraclass correlation coefficient 0.706-0.835). Mean difference between operators was the lowest for the PNT and PFSR (0.03-0.08). Measurements in abnormal fetuses showed that the majority of trisomy 21 fetuses had either an absent nasal bone or a shorter NBL. The PNT and PNT/NBL ratio were above the 97.5th centile in one third of the cases. Fetuses with facial clefts or micrognathia showed on average a large MNM angle (multiple of the median 0.96-5.15). Conclusion: First-trimester facial markers are feasible. The PNT and PNT/NBL ratio were increased in one third of the trisomic fetuses, and the MNM angle in the majority of fetuses with micrognathia and facial clefts.

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Section: Discussionmentioning

confidence: 99%

Prenasal Thickness, Prefrontal Space Ratio and Other Facial Profile Markers in First-Trimester Fetuses with Aneuploidies, Cleft Palate, and Micrognathia

et al. 2016

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“…Yazdi et al found that the MML coursed behind the prenasal skin in a considerable number of Down syndrome cases which is potentially predictive of fetal aneuploidy in the second and third trimester [20]. Recently, the same group reported significant differences between euploid and aneuploid fetuses (including trisomy 21, 18 and 13) regarding the frontal space assessed at 11-13 gestational weeks and the impact on first-trimester combined aneuploidy screening [23]. In contrast to the described MMN angle having its vertex on the anterior edge of the mandible, the previously described MNM (between 2 lines originating from the nasion and tracing the anterior borders of the mandible and the maxilla, respectively) [24] is found to be a weak DS marker as less than 25 % of trisomy 21 fetuses had abnormal values [22].…”

mentioning

confidence: 99%

Assessment of Midfacial Hypoplasia in Down Syndrome Fetuses – Validity of a Two-Line Approach and Introduction of a Novel Angle (Maxilla-Mandible-Nasion Angle)

Weichert

Gembicki

Ribbat‐Idel

et al. 2016

Ultrasound International Open

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“…Bakker et al berichteten, dass die pränasale Dicke bei etwa einem Drittel der aneuploiden Feten über der 97,5ten Perzentile liegt [50]. Die "prefrontal space ratio" aus dem zweiten Trimenon wurde etwas vereinfacht als "prefrontal space distance" untersucht [53]. Dabei wird eine Linie tangential von dem ventralsten Verknöcherungspunkt der Mandibula zur Maxilla gezogen und zur Stirn verlängert (▶ Abb.…”

Section: Auffälligkeiten Im Bereich Des Mittelgesichtsunclassified

Das fetale Profil im ersten Trimenon – mehr als nur NT

Hoopmann¹,

Kagan²

2017

Ultraschall in Med

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The midsagittal view of the fetal profile is essential in first trimester screening at 11 + 0 to 13 + 6 weeks of gestation. None of the standard sections in prenatal medicine is as well defined and undergoes such a strong quality assurance program. These requirements were recently challenged by the introduction of cell-free DNA screening. The fetal profile view was previously only needed for the appropriate measurement of the fetal nuchal translucency thickness. In recent years, it became evident that there are many more anomalies or markers for fetal defects that can be seen in this section such as spina bifida, facial clefts or retrognathia. The aim of this review is to summarize the additional information that can be gained from the fetal profile view.

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The frontal space measurement in euploid and aneuploid pregnancies at 11–13 weeks' gestation

Abstract: First trimester FS measurement may improve first trimester combined screening.

Cited by 9 publications

References 23 publications

Prenasal Thickness, Prefrontal Space Ratio and Other Facial Profile Markers in First-Trimester Fetuses with Aneuploidies, Cleft Palate, and Micrognathia

Prenasal Thickness, Prefrontal Space Ratio and Other Facial Profile Markers in First-Trimester Fetuses with Aneuploidies, Cleft Palate, and Micrognathia

Assessment of Midfacial Hypoplasia in Down Syndrome Fetuses – Validity of a Two-Line Approach and Introduction of a Novel Angle (Maxilla-Mandible-Nasion Angle)

Das fetale Profil im ersten Trimenon – mehr als nur NT

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