The Fruit and Veggies for Kidney Health Study: A Prospective Randomized Trial

Kitzman, Heather; Montgomery, Aisha H.; Khan, Mahbuba; Mamun, Abdullah; Tecson, Kristen M.; Allison, Patricia; Simoni, Jan; Wesson, Donald E.

doi:10.1016/j.xkme.2023.100736

Cited by 2 publications

(3 citation statements)

References 73 publications

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“…Within a 6-week intervention period, we found nonsignificant outcomes in measured variables. Previous studies reported that a base-producing FV intervention was correlated with significant ACR reductions at 4 weeks [ 51 ]; however, our findings showed nonsignificant ACR reduction at 6 weeks, supporting a similar FV intervention study [ 52 ]. Unlike earlier studies that provided 2 cups of F&V per day to the entire participant household, the present feasibility trial provided F&V only to study participants [ 38 , 51 , 53 , 54 ].…”

Section: Discussionsupporting

confidence: 76%

“…Unlike earlier studies that provided 2 cups of F&V per day to the entire participant household, the present feasibility trial provided F&V only to study participants [ 38 , 51 , 53 , 54 ]. Additionally, another FV intervention trial provided food preparation instructions adjunctive to F&V and the intervention group experienced ACR reduction [ 52 ]. By providing cooking instructions [ 52 ] or guided goal setting with the participant [ 55 , 56 ], the FV intervention improved dietary and observed health outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, another FV intervention trial provided food preparation instructions adjunctive to F&V and the intervention group experienced ACR reduction [ 52 ]. By providing cooking instructions [ 52 ] or guided goal setting with the participant [ 55 , 56 ], the FV intervention improved dietary and observed health outcomes. Considering the cultural, social, dietary, and lifestyle variations among AA communities, FV interventions may need multi-theoretical approaches (i.e., targeting community, interpersonal, or individual levels [socioecological model [ 57 ]]) for optimal clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Metabolomic and Physiological Effects of a Cardiorenal Protective Diet Intervention in African American Adults with Chronic Kidney Disease

Patel,

Emerenini,

Wang

et al. 2024

Metabolites

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Chronic kidney disease (CKD) impacts 14% of adults in the United States, and African American (AA) individuals are disproportionately affected, with more than 3 times higher risk of kidney failure as compared to White individuals. This study evaluated the effects of base-producing fruit and vegetables (FVs) on cardiorenal outcomes in AA persons with CKD and hypertension (HTN) in a low socioeconomic area. The “Cardiorenal Protective Diet” prospective randomized trial evaluated the effects of a 6-week, community-based FV intervention compared to a waitlist control (WL) in 91 AA adults (age = 58.3 ± 10.1 years, 66% female, 48% income ≤ USD 25K). Biometric and metabolomic variables were collected at baseline and 6 weeks post-intervention. The change in health outcomes for both groups was statistically insignificant (p > 0.05), though small reductions in albumin to creatinine ratio, body mass index, total cholesterol, and systolic blood pressure were observed in the FV group. Metabolomic profiling identified key markers (p < 0.05), including C3, C5, 1-Met-His, kynurenine, PC ae 38:5, and choline, indicating kidney function decline in the WL group. Overall, delivering a directed cardiorenal protective diet intervention improved cardiorenal outcomes in AA adults with CKD and HTN. Additionally, metabolomic profiling may serve as a prognostic technique for the early identification of biomarkers as indicators for worsening CKD and increased CVD risk.

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