The FTO Gene, Browning of Adipose Tissue and Omega-3 Fatty Acids

Simopoulos, Artemis P.

doi:10.1159/000448617

Cited by 7 publications

(1 citation statement)

References 19 publications

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“…Omega-6 fatty acids have been shown to have negative effects on brown fat. Experimental studies have suggested that omega-6 PUFA leads to white fat deposits and obesity, while omega-3 fatty acids increase thermogenesis through the expression of UCP1 and increase fatty acid oxidation [ 73 , 79 , 97 ]. A study found that a balanced diet of omega-6 and omega-3 fatty acids increased the mass of axillary brown adipose tissue in Arctic ground squirrels [ 98 ].…”

Section: Nutritional Factors Regulate Bat Activitymentioning

confidence: 99%

Brown Fat and Nutrition: Implications for Nutritional Interventions

Noriega,

Yang,

Wang

2023

Nutrients

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Brown and beige adipocytes are renowned for their unique ability to generate heat through a mechanism known as thermogenesis. This process can be induced by exposure to cold, hormonal signals, drugs, and dietary factors. The activation of these thermogenic adipocytes holds promise for improving glucose metabolism, reducing fat accumulation, and enhancing insulin sensitivity. However, the translation of preclinical findings into effective clinical therapies poses challenges, warranting further research to identify the molecular mechanisms underlying the differentiation and function of brown and beige adipocytes. Consequently, research has focused on the development of drugs, such as mirabegron, ephedrine, and thyroid hormone, that mimic the effects of cold exposure to activate brown fat activity. Additionally, nutritional interventions have been explored as an alternative approach to minimize potential side effects. Brown fat and beige fat have emerged as promising targets for addressing nutritional imbalances, with the potential to develop strategies for mitigating the impact of metabolic diseases. Understanding the influence of nutritional factors on brown fat activity can facilitate the development of strategies to promote its activation and mitigate metabolic disorders.

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