The FTO gene is not associated with weight gain during six years of observation in the population of the PURE study in Poland

Abstract

Introduction: We present the first longitudinal study in Poland analysing the association between fat mass and obesity-associated gene (FTO) polymorphism and changes in anthropometric parameters. Material and methods: 1120 participants of the Prospective Urban Rural (PURE) study in Poland (mean age 53.7 years) were genotyped for FTO gene polymorphism (rs9939609, rs9930506, rs1421085, rs1121980). Anthropometric parameters were measured at three time points (baseline, after three years, and after six years of observation). Results: The mean body mass index (BMI) in the study group was 28 kg/m 2. Overall, there was a significant increase in the mean weight, BMI, and waist size during the six years (p ª 0). Although males initially weighed more than females (p = 0), over the whole six-year period women had a greater tendency to increase in weight (p = 0.068), BMI (p = 0.014), and waist size (p = 0.041). Subjects with at least one A allele at rs9939609 initially weighed more on average (77.5 vs. 74.7 kg, p = 0.027) and had a greater waist size (92 vs. 89.5 cm, p = 0.025) than those with the TT genotype. The differences in baseline results were more expressed in males than in females. There is no association between the changes in anthropometric parameters over the whole study period of six years and the FTO gene. Conclusions: FTO gene polymorphism is associated with anthropometric parameters in participants from the PURE study in Poland. However, there is no association between the presence of risk alleles and changes of anthropometric parameters over six years of observation.

The Impact of Haplotypes of the FTO Gene, Lifestyle, and Dietary Patterns on BMI and Metabolic Syndrome in Polish Young Adult Men

“…In one such study, the rs9939609 polymorphism was analyzed in 1097 persons aged 30–80, but a correlation with BMI was found only among males [ 44 ]. During the 6-year follow–up, there was no significant impact of rs9939609 polymorphisms on body mass increase [ 45 ]. In another study, which was conducted by Kolačkov et al, there was no significant correlation between the FTO polymorphisms (rs1421085, rs1121980, rs9939609, and rs9930506) and BMI among persons with a BMI < 25, although there was a tendency for an increased hip circumference among women with haplotype TCGA [ 29 ].…”

The role of epidemiological research in public health using the PURE Poland study as an example

“…The main research directions in the analyses of the data collected in the Polish PURE cohort during the longterm follow-up period focused on dietary factors [8][9][10][11][12][13][14][15][16], the effect of CETP and PLTP protein activity on lipid disorders [17,18], overweight and obesity [19][20][21][22], atti- tudes toward tobacco smoking [23][24][25][26], alcohol consumption [27], sleep [28], quality of life [29], prevalence and determinants of hypertension [30,31], and carbohydrate metabolism disorders [32][33][34][35][36].…”