2017
DOI: 10.1111/bjh.15019
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The full spectrum of Castleman disease: 273 patients studied over 20 years

Abstract: The spectrum of Castleman disease (CD) has considerably extended since its first description in 1956. Recently, an international collaborative working group has reached consensus on the diagnostic criteria and classification of CD. We herein report 273 patients with lymph node histopathology consistent with CD and investigate the newly established diagnostic criteria. Twenty of these patients with Castleman-like histopathology were removed from analyses, because they were diagnosed with an exclusionary disorde… Show more

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Cited by 167 publications
(175 citation statements)
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“…Although laboratory inflammation is expected among MCD patients, our UCD population appeared to have increased inflammation compared with adult cohorts. For example, whereas in our cohort, 45% of UCD patients had an elevated ESR, in an adult UCD cohort this rate was 19%, and 50% had an elevated CRP …”
Section: Discussioncontrasting
confidence: 64%
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“…Although laboratory inflammation is expected among MCD patients, our UCD population appeared to have increased inflammation compared with adult cohorts. For example, whereas in our cohort, 45% of UCD patients had an elevated ESR, in an adult UCD cohort this rate was 19%, and 50% had an elevated CRP …”
Section: Discussioncontrasting
confidence: 64%
“…Similarly, in our pediatric/AYA cohort, systemic symptoms were more common among MCD patients than UCD patients, although this difference in presentations by centricity is less striking than in adults. For example, 44% presented with systemic symptoms, which is above the upper range of the reported 10–40% rate of systemic symptoms reported in adult UCD reports . Among HHV8‐negative MCD patients in this cohort, four and six (67%) had systemic symptoms, which is at the lower end of the 60–80% range reported in adult cohorts …”
Section: Discussionmentioning
confidence: 44%
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