Several distinct trends will influence space exploration missions in the next decade. Destinations are becoming more remote and mysterious, science questions more sophisticated, and, as mission experience accumulates, the most accessible targets are visited, advancing the knowledge frontier to more difficult, harsh, and inaccessible environments. This leads to new challenges including: hazardous conditions that limit mission lifetime, such as high radiation levels surrounding interesting destinations like Europa or toxic atmospheres of planetary bodies like Venus; unconstrained environments with navigation hazards, such as free-floating active small bodies; multielement missions required to answer more sophisticated questions, such as Mars Sample Return (MSR); and long-range missions, such as Kuiper belt exploration, that must survive equipment failures over the span of decades. These missions will need to be successful without a priori knowledge of the most efficient data collection techniques for optimum science return. Science objectives will have to be revised 'on the fly', with new data collection and navigation decisions on short timescales. Yet, even as science objectives are becoming more ambitious, several critical resources remain unchanged. Since physics imposes insurmountable light-time delays, anticipated improvements to the Deep Space Network (DSN) will only marginally improve the bandwidth and communications cadence to remote spacecraft. Fiscal resources are increasingly limited, resulting in fewer flagship missions, smaller spacecraft, and less subsystem redundancy. As missions visit more distant and formidable locations, the job of the operations team becomes more challenging, seemingly inconsistent with the trend of shrinking mission budgets for operations support. How can we continue to explore challenging new locations without increasing risk or system complexity? These challenges are present, to some degree, for the entire Decadal Survey mission portfolio, as documented in Vision and Voyages for Planetary Science in the