2018
DOI: 10.1042/bst20170518
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The fumarylacetoacetate hydrolase (FAH) superfamily of enzymes: multifunctional enzymes from microbes to mitochondria

Abstract: Prokaryotic and eukaryotic fumarylacetoacetate hydrolase (FAH) superfamily members, sharing conserved regions that form the so-called FAH-domain, catalyze a remarkable variety of reactions. These enzymes are essential in the metabolic pathways to degrade aromatic compounds in prokaryotes and eukaryotes. It appears that prokaryotic FAH superfamily members evolved mainly to allow microbes to generate energy and useful metabolites from complex carbon sources. We review recent findings, indicating that both prokar… Show more

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Cited by 38 publications
(36 citation statements)
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“…The superfamily of fumarylacetoacetate hydrolase (FAH) proteins describes enzymes that share a conserved catalytic center, yet exhibit multifunctionality in prokaryotes and eukaryotes [1]. Whereas many distinct FAH superfamily members were described in prokaryotes [1], the only identified members in eukaryotes are FAH and FAH domain containing proteins 1 and 2 (FAHD1 and FAHD2) [1][2][3].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The superfamily of fumarylacetoacetate hydrolase (FAH) proteins describes enzymes that share a conserved catalytic center, yet exhibit multifunctionality in prokaryotes and eukaryotes [1]. Whereas many distinct FAH superfamily members were described in prokaryotes [1], the only identified members in eukaryotes are FAH and FAH domain containing proteins 1 and 2 (FAHD1 and FAHD2) [1][2][3].…”
Section: Introductionmentioning
confidence: 99%
“…The superfamily of fumarylacetoacetate hydrolase (FAH) proteins describes enzymes that share a conserved catalytic center, yet exhibit multifunctionality in prokaryotes and eukaryotes [1]. Whereas many distinct FAH superfamily members were described in prokaryotes [1], the only identified members in eukaryotes are FAH and FAH domain containing proteins 1 and 2 (FAHD1 and FAHD2) [1][2][3]. FAHD1 was identified as oxaloacetate decarboxylase (ODx), and as such acts as a regulatory enzyme in the TCA cycle; accordingly, as it was associated with the regulation of mitochondrial function [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…Some of the selected mRNAs have been associated with the Krebs cycle or respiratory chain complexes. This is the case for Fahd1 (Pircher et al, 2015;Weiss et al, 2018), Lyrm5 (Floyd et al, 2016;Pagliarini et al, 2008), and Fh1 (Tyrakis et al, 2017). Interestingly, a reduction in Fh1 leads to mitochondrial respiratory chain defects, particularly in the complex I and II (Tyrakis et al, 2017).…”
Section: Transcript Analysis Reveals Oxidative Phosphorylation As a Cmentioning
confidence: 87%
“…The fumarylacetoacetate hydrolase (FAH) 1,2 superfamily of enzymes describes a group of enzymes that share the highly conserved catalytic FAH domain 3,4,5,6,7,8,9,10 . Despite their common catalytic center, these enzymes are multi-functional, and most are found in prokaryotes, where they are used to break down compounds retrieved from complex carbon sources 3 .…”
Section: Introductionmentioning
confidence: 99%
“…Culture bacteria in the bacterial incubator at 37 °C for 2-3 h ( Figure 1C). 3. After 2-3 h, draw a sample for photometric analysis.…”
Section: Introductionmentioning
confidence: 99%