The function and failure of sensory predictions

Bansal, Sonia; Ford, Judith M.; Spering, Miriam

doi:10.1111/nyas.13686

Cited by 55 publications

(35 citation statements)

References 200 publications

(310 reference statements)

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“…The interactions of pathways that underlie the complex processes for decision and action are disrupted in psychosis (reviewed in [61]) and in anxiety disorders that affect emotional processing through the amygdala (e.g., [5]). Considerable evidence suggests disruption of corollary discharge mechanisms in schizophrenia, affecting the sense of agency and attribution of thoughts, desires, and actions to external sources (e.g., [62][63][64][65][66][67][68][69][70]). The thalamocortical motif that links the thalamus with high-order association prefrontal cortices is likely vulnerable to disruption along multiple dimensions, including the known deficits in eye movements in schizophrenia, as shown in computational studies [71].…”

Section: Plos Biologymentioning

confidence: 99%

Organization of primate amygdalar–thalamic pathways for emotions

et al. 2020

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Studies on the thalamus have mostly focused on sensory relay nuclei, but the organization of pathways associated with emotions is not well understood. We addressed this issue by testing the hypothesis that the primate amygdala acts, in part, like a sensory structure for the affective import of stimuli and conveys this information to the mediodorsal thalamic nucleus, magnocellular part (MDmc). We found that primate sensory cortices innervate amygdalar sites that project to the MDmc, which projects to the orbitofrontal cortex. As in sensory thalamic systems, large amygdalar terminals innervated excitatory relay and inhibitory neurons in the MDmc that facilitate faithful transmission to the cortex. The amygdala, however, uniquely innervated a few MDmc neurons by surrounding and isolating large segments of their proximal dendrites, as revealed by three-dimensional high-resolution reconstruction. Physiologic studies have shown that large axon terminals are found in pathways issued from motor systems that innervate other brain centers to help distinguish self-initiated from other movements. By analogy, the amygdalar pathway to the MDmc may convey signals forwarded to the orbitofrontal cortex to monitor and update the status of the environment in processes deranged in schizophrenia, resulting in attribution of thoughts and actions to external sources.

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Section: Plos Biologymentioning

confidence: 99%

Organization of primate amygdalar–thalamic pathways for emotions

et al. 2020

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“…For example, impaired ability to differentiate external from self-produced sensory events has been linked to neuropsychiatric symptoms in schizophrenia (Blakemore, Smith, Steel, Johnstone, & Frith, 2000;Lemaitre, Luyat, & Lafargue, 2016;Lindner, Thier, Kircher, Haarmeier, & Leube, 2005;Spering, Dias, Sanchez, Schütz, & Javitt, 2013). This important topic has been covered by recent reviews (Bansal, Ford, & Spering, 2018;Thakkar, Diwadkar, & Rolfs, 2017) and will not be discussed here. Instead, we will review the mechanisms underlying sensory regulation based on normally functioning predictions of sensory action consequences.…”

Section: Predicting Sensory Consequences Of Movementsmentioning

confidence: 99%

Prediction in goal-directed action

2019

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Prediction allows humans and other animals to prepare for future interactions with their environment. This is important in our dynamically changing world that requires fast and accurate reactions to external events. Knowing when and where an event is likely to occur allows us to plan eye, hand, and body movements that are suitable for the circumstances. Predicting the sensory consequences of such movements helps to differentiate between self-produced and externally generated movements. In this review, we provide a selective overview of experimental studies on predictive mechanisms in human vision for action. We present classic paradigms and novel approaches investigating mechanisms that underlie the prediction of events guiding eye and hand movements.

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“…Perceptual alterations caused by sensorimotor conflicts of upper-limb movements have also been observed in sensory domains other than somatosensation. For instance, studies reported a change in loudness perception of self-generated tones (by a button press), compared to tones presented passively [22][23][24][25] , which was associated with attenuated neural responses [26][27][28][29][30] . Recent studies have demonstrated that such auditory-motor self-attenuation effects can also be obtained for more complex sounds, such as voices 31,32 .…”

Section: Introductionmentioning

confidence: 99%

Sensorimotor conflicts induce somatic passivity and louden quiet voices in healthy listeners

Orepic

Rognini

Kannape

et al. 2020

Preprint

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Word count: Abstract: 234 Text body with abstract: 3981 2 Abstract Sensorimotor conflicts are known to alter the perception of accompanying sensory signals and deficits in sensory attenuation have been observed in schizophrenia. In the auditory domain, selfgenerated tones or voices (compared to tones or voices presented passively or with sensorimotor delays) have been associated with changes in loudness perception and attenuated neural responses. It has been argued that for sensory signals to be attenuated, predicted and sensory consequences must have a consistent spatiotemporal relationship, between button presses and reafferent tactile signals, via predictive sensory signaling, a process altered in schizophrenia.Here, we investigated auditory sensory attenuation for a series of morphed voices while healthy participants applied sensorimotor stimulations that had no spatiotemporal relationship to the voice stimuli and that have been shown to induce mild psychosis-like phenomena. In two independent groups of participants, we report a loudening of silent voices and found this effect only during maximal sensorimotor conflicts (versus several control conditions). Importantly, conflicting sensorimotor stimulation also induced a mild psychosis-like state in the form of somatic passivity and participants who experienced stronger passivity lacked the sensorimotor loudening effect. We argue that this conflict-related sensorimotor loudness amplification may represent a reduction of auditory self-attenuation that is lacking in participants experiencing a concomitant mild psychosis-like state. We interpret our results within the framework of the comparator model of sensorimotor control, and discuss the implications of our findings regarding passivity experiences and hallucinations in schizophrenia.

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The function and failure of sensory predictions

Cited by 55 publications

References 200 publications

Organization of primate amygdalar–thalamic pathways for emotions

Organization of primate amygdalar–thalamic pathways for emotions

Prediction in goal-directed action

Sensorimotor conflicts induce somatic passivity and louden quiet voices in healthy listeners

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