The function and mechanisms of action of circular RNAs in Urologic Cancer

Zhang, Zi-Hao; Wang, Yue; Zhang, Ya; Zheng, Sheng-Feng; Feng, Tao; Tian, Xi; Abudurexiti, Mierxiati; Wang, Zhen-Da; Zhu, Wenkai; Su, Jiaqi; Zhang, Hai-Liang; Shi, Guohai; Wang, Ziliang; Cao, Dalong; Ye, Dingwei

doi:10.1186/s12943-023-01766-2

Cited by 34 publications

(6 citation statements)

References 203 publications

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“…This indicates an opposing effect between hsa_circ_0036474 and miR-223-3p in EC109 cells, and cir-cRNA-0036474 could have significant effects by modulating miR-223-3p expression. These obtained results were in agreement with the other studies [15,16], indicating that some key circRNAs could play a role through related miR-NAs. Notably, the hsa_circ_0036474 levels were markedly increased within the EC109 cells.…”

Section: Discussionsupporting

confidence: 93%

Expression of circRNA-0036474 in esophageal cancer and its clinical significance

Chen

2024

Am J Cancer Res

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Circular RNAs are considered to play important roles in the progression of different cancers such as esophageal squamous cell carcinoma. However, the functions of circular RNAs in esophageal squamous cell carcinoma are still not clear. This study aimed to investigate the role and mechanism of circRNA-0036474 in the progression of esophageal squamous cell carcinoma. The hsa_circ_0036474 expression levels were found to be elevated in both EC109 cells and esophageal squamous cell carcinoma tissue samples. Moreover, knockdown of circRNA-0036474 expression in the EC109 cells induced migration and invasion, characterized by the down-regulation of E-cadherin, and up-regulation of N-cadherin and vimentin. In addition, the over-expressed hsa_circ_0036474 significantly decreased the activity of EC109 cells, elevated E-cadherin expression but declined N-cadherin and vimentin expression. Moreover, over-expressed mir-223-3p levels and interfered RERG expression verified the role of hsa_circ_0036474 in inhibiting the invasion and migration of EC109 cells, reducing the expression of N-cadherin and vimentin, and promoting the expression of E-cadherin. In conclusion, circRNA-0036474 mitigated the progression of esophageal squamous cell carcinoma through regulating mir-223-3p/RERG axis, presenting a potential therapeutic target for the treatment.

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Section: Discussionsupporting

confidence: 93%

Expression of circRNA-0036474 in esophageal cancer and its clinical significance

Chen

2024

Am J Cancer Res

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“…Multiple studies have shown that noncoding RNAs govern carcinogenesis in bladder cancer (143)(144)(145)(146). Noncoding RNAs are transcribed from DNA, but not translated into proteins, including microRNAs (miRNAs), lncRNAs (log noncoding RNAs), siRNAs (small interfering RNAs), snRNAs (small nuclear RNAs) and piRNAs (147)(148)(149).…”

Section: Noncoding Rnas Target E3 Ligasesmentioning

confidence: 99%

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

Wang

Zhang

et al. 2023

Front. Immunol.

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Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and progression. Ubiquitination is the common PTM, which is conducted by E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme and E3 ubiquitin-protein ligase. E3 ubiquitin ligases play a key role in bladder oncogenesis and progression and drug resistance in bladder cancer. Therefore, in this review, we summarize current knowledge regarding the functions of E3 ubiquitin ligases in bladder cancer development. Moreover, we provide the evidence of E3 ubiquitin ligases in regulation of immunotherapy in bladder cancer. Furthermore, we mention the multiple compounds that target E3 ubiquitin ligases to improve the therapy efficacy of bladder cancer. We hope our review can stimulate researchers and clinicians to investigate whether and how targeting E3 ubiquitin ligases acts a novel strategy for bladder cancer therapy.

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“…Circular RNAs (circRNAs), which have covalently linked ends, have attracted increasing attention because of their potential for biological activity in different clinical fields, including cancer biology [ 4 , 5 ]. It was shown that circRNAs isolated from urine can serve as biomarkers for different urological diseases [ 6 ]. CircRNAs are generated during pre-mRNA splicing when a downstream 5′ splice site is joined to an upstream 3′ splice site [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Circular STAG2 RNA Modulates Bladder Cancer Progression via miR-145-5p/TAGLN2 and Is Considered as a Biomarker for Recurrence

Du,

Waltzer,

Wilusz

et al. 2024

Cancers

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The current study aimed to elucidate the regulatory mechanisms of the circRNA hsa_circ_0139697 (circSTAG2(16–25)) in BCa and to consider the opportunity of using circSTAG2(16–25) isolated from BCa patient urine as a marker for disease development prediction. The selection of this circRNA was determined by the special role of its parental gene STAG2 in BCa biology. The circRNA hsa_circ_0139697 was chosen from 25 STAG2 circRNAs due to its differential expression in the urine of BCa patients and healthy volunteers. Higher levels of circSTAG2(16–25) were detected in urine samples obtained from patients with recurrent tumors. A higher expression of circSTAG2(16–25) was also detected in more tumorigenic BCa cell lines. The overexpression of circSTAG2(16–25) in BCa cells induced the elevation of proliferation, motility, and invasion. To study the mechanisms of circSTAG2(16–25) activity, we confirmed that circSTAG2(16–25) can bind miR-145-5p in vitro as was predicted by bioinformatic search. miR-145-5p was shown to suppress some genes that promoted BCa progression. One of these genes, TAGLN2, encodes the protein Transgelin 2, which plays a role in BCa cell motility and invasion. Therefore, the possible mechanism of action of circSTAG2(16–25) could be sponging the tumor suppressor miR-145-5p, which results in activation of TAGLN2. In addition, circSTAG2(16–25) might be considered as a potential biomarker for recurrence prediction.

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The function and mechanisms of action of circular RNAs in Urologic Cancer

Cited by 34 publications

References 203 publications

Expression of circRNA-0036474 in esophageal cancer and its clinical significance

Expression of circRNA-0036474 in esophageal cancer and its clinical significance

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

Circular STAG2 RNA Modulates Bladder Cancer Progression via miR-145-5p/TAGLN2 and Is Considered as a Biomarker for Recurrence

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