The function of MMP‑28/TGF‑β induced cell apoptosis in human glioma cells

Wang, Xuepeng; Chen, Xi; Sun, Lin; Bi, Xiaoli; He, Hai‐Tao; Chen, Lei; Pang, Jiaping

doi:10.3892/etm.2018.6566

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…The development of human cancer is always accompanied with an abnormal status of numerous cell behaviors, therefore the role of miRNA in human cancer have also been extensively studied . A growing body of evidence has highlighted the critical role of miRNAs in glioma . In this study, we focused to investigate the expression pattern and biological role of miR‐199a‐5p in glioma.…”

Section: Discussionmentioning

confidence: 99%

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microRNA‐199a‐5p suppresses glioma progression by inhibiting MAGT1

Wang

et al. 2019

J of Cellular Biochemistry

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microRNAs (miRNAs) can function as a tumor suppressor or oncogenic genes in human cancers. Alternation expression of miR‐199a‐5p has been revealed in several human cancers. However, its expression pattern and biological roles in glioma remain unclear. Expression levels of miR‐199a‐5p in glioma were evaluated at first. The effects of miR‐199a‐5p expression on cell proliferation, migration, and invasion were investigated using the MTT assay, wound‐healing assay, and transwell invasion assay. The expression of miR‐199a‐5p was found to be reduced in glioma cell lines. Overexpression of miR‐199a‐5p inhibits glioma cell proliferation, migration, and invasion in vitro. Furthermore, the target of miR‐199a‐5p was predicted by TargetScan and validated by luciferase activity reporter assay. We found magnesium transporter 1 (MAGT1) was a direct target of miR‐199a‐5p. Overexpression of MAGT1 reversed the effects of miR‐199a‐5p on glioma cell behaviors. Taken together, our study revealed that miR‐199a‐5p and MAGT1 have the potential to be used as a biomarker for glioma.

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Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11][12][13] A growing body of evidence has highlighted the critical role of miRNAs in glioma. 4,14,15 In this study, we focused to investigate the expression pattern and biological role of miR-199a-5p in glioma. The expression level of miR-199a-5p in glioma was analyzed by qRT-PCR.…”

Section: Discussionmentioning

confidence: 99%

microRNA‐199a‐5p suppresses glioma progression by inhibiting MAGT1

Wang

et al. 2019

J of Cellular Biochemistry

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“…Glioma is an aggressive central nervous system malignancy, which greatly affects human health (16). Owing to rapid proliferation, metastasis and angiogenesis, this disease is relatively hard to treat (17,18). The prognosis of patients with glioma is relatively poor due to metastasis and recurrence (3,19).…”

Section: Discussionmentioning

confidence: 99%

Identification of differentially expressed microRNAs and the potential of microRNA‑455‑3p as a novel prognostic biomarker in glioma

Wang

Zhao³

et al. 2019

Oncol Lett

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Glioma is an aggressive central nervous system malignancy. MicroRNAs (miRNAs/miRs) have been reported to be involved in the tumorigenesis of numerous types of cancer, including glioma. The present study aimed to identify the differentially expressed miRNAs in glioma, and further explore the clinical value of miR-455-3p in patients with glioma. GEO2R was used for the identification of the differentially expressed miRNAs according to the miRNA expression profiles obtained from the Gene Expression Omnibus database. OncomiR was used to analyze the relationship of miRNAs with the survival outcomes of the patients with glioma. A total of 108 patients with glioma were recruited to examine the expression levels of miR-455-3p and further explore its clinical value. The bioinformatics analysis results suggested that a total of 64 and 48 differentially expressed miRNAs were identified in the GSE90603 and GSE103229 datasets, respectively. There were 12 miRNAs in the overlap of the two datasets, of which three were able to accurately predict overall cancer survival, namely hsa-miR-7-5p, hsa-miR-21-3p and hsa-miR-455-3p. In patients with glioma, miR-455-3p was determined to be significantly upregulated (P<0.001). Additionally, patients with high miR-455-3p expression had significantly lower 5-year overall survival than those with low miR-455-3p expression (log-rank test, P=0.001). Cox regression analysis further determined that miR-455-3p was an independent prognostic indicator for overall survival in patients with glioma (hazard ratio=2.136; 95% CI=1.177-3.877; P=0.013). In conclusion, the present study revealed a series of miRNAs with potential functional roles in the pathogenesis of glioma, and provides findings that indicate miR-455-3p as a promising biomarker for the prognosis of glioma.

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“…In normal circumstances, the synthesis and degradation of ECM is a homeostatic process regulated by the balanced activity of MMPs. However, in tumor tissues, this homeostasis is disrupted due to the overexpressed or hyperactivated of MMPs in gliomas, such as MMP2, MMP9 MMP3, MMP13, MMP14, MMP19, MMP26, and MMP28 ( 75 – 84 ). After effective treatment of U87 glioma xenografts with TMZ, MMP expression is downregulated, with the downregulation of MMP2 and MMP3 associated with the inhibitory effects of TMZ on gliomas ( 85 ).…”

Section: Molecular Regulatory Mechanisms Of Glioma-associated Fibrosismentioning

confidence: 99%

The tumor-associated fibrotic reactions in microenvironment aggravate glioma chemoresistance

Xu,

Zhang,

Chen

et al. 2024

Front. Oncol.

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Malignant gliomas are one of the most common and lethal brain tumors with poor prognosis. Most patients with glioblastoma (GBM) die within 2 years of diagnosis, even after receiving standard treatments including surgery combined with concomitant radiotherapy and chemotherapy. Temozolomide (TMZ) is the first-line chemotherapeutic agent for gliomas, but the frequent acquisition of chemoresistance generally leads to its treatment failure. Thus, it’s urgent to investigate the strategies for overcoming glioma chemoresistance. Currently, many studies have elucidated that cancer chemoresistance is not only associated with the high expression of drug-resistance genes in glioma cells but also can be induced by the alterations of the tumor microenvironment (TME). Numerous studies have explored the use of antifibrosis drugs to sensitize chemotherapy in solid tumors, and surprisingly, these preclinical and clinical attempts have exhibited promising efficacy in treating certain types of cancer. However, it remains unclear how tumor-associated fibrotic alterations in the glioma microenvironment (GME) mediate chemoresistance. Furthermore, the possible mechanisms behind this phenomenon are yet to be determined. In this review, we have summarized the molecular mechanisms by which tumor-associated fibrotic reactions drive glioma transformation from a chemosensitive to a chemoresistant state. Additionally, we have outlined antitumor drugs with antifibrosis functions, suggesting that antifibrosis strategies may be effective in overcoming glioma chemoresistance through TME normalization.

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The function of MMP‑28/TGF‑β induced cell apoptosis in human glioma cells

Cited by 3 publications

References 17 publications

microRNA‐199a‐5p suppresses glioma progression by inhibiting MAGT1

microRNA‐199a‐5p suppresses glioma progression by inhibiting MAGT1

Identification of differentially expressed microRNAs and the potential of microRNA‑455‑3p as a novel prognostic biomarker in glioma

The tumor-associated fibrotic reactions in microenvironment aggravate glioma chemoresistance

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