The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis

Guo, Yafei; Li, Yang; Cao, Qiang; Ye, Leilei; Wang, Junmei; Guo, Mei

doi:10.3389/fphar.2022.927855

Cited by 12 publications

(8 citation statements)

References 84 publications

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“…Polysaccharides extracted from Arctium lappa considerably improve gut microbiota by promoting Proteobacteria, Alcaligenaceae, Staphylococcus, and Bacteroidetes, which are beneficial for the relief of UC [41]. In addition, Rheum Tanguticum, Codonopsis pilosula, and other plant polysaccharides can regulate intestinal flora and alleviate UC [42]. In addition to polysaccharides, 5-10% of dietary protein is not absorbed as proteins and peptides when it passes through the ileum and enters the colon.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Different Molecular Weights of Purslane (Portulaca oleracea L.) Aqueous Extract on DSS-Induced Ulcerative Colitis in Mice

et al. 2023

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Purslane, a common wild vegetable, contains active substances with various biological functions. However, its effects have been under-investigated in ulcerative colitis (UC). Therefore, this study investigated the therapeutic effects of purslane macromolecular (POEM) and small molecular extracts (POES) on dextran sulfate sodium (DSS)-induced UC in mice. Membrane separation was used to obtain extracts of different molecular weights, and their compositional differences were compared using liquid chromatography–mass spectrometry (LC/MS). POEM contained more proteins and polysaccharides, whereas POES contained more organic acids and alkaloids. These differences in composition were directly responsible for the different degrees of remission of the alleviated UC in model mice. POEM may alleviate UC by regulating the antioxidant capacity and the gut microbiota, whereas the major alleviatory effect of POES was primarily related to the regulation of antioxidant capacity. The POEM and POES effects identified in this study provide a theoretical basis for the development of purslane as a functional food.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Different Molecular Weights of Purslane (Portulaca oleracea L.) Aqueous Extract on DSS-Induced Ulcerative Colitis in Mice

et al. 2023

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“…Studies have shown that traditional Chinese medicine has a significant effect on the treatment of NAFLD with fewer adverse reactions [ 137 ]. Polysaccharides, as a class of natural macromolecules widely present in traditional Chinese medicines (TCM), have attracted much attention due to their rich activities and reliable biosafety [ 138 , 139 , 140 , 141 ]. In recent years, it has been found that polysaccharides, especially from TCM, have the potential to prevent and treat NAFLD with diverse structures and mechanisms of action.…”

Section: Discussionmentioning

confidence: 99%

Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis

Chen

Liu

Tang

et al. 2022

IJMS

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease affecting global public health at present, which can induce cirrhosis and liver cancer in serious cases. However, NAFLD is a multifactorial disease, and there is still a lack of research on its mechanism and therapeutic strategy. With the development of the gut–liver axis theory, the association between the gut–liver axis and the pathogenesis of NAFLD has been gradually disclosed. Polysaccharides, as a kind of natural product, have the advantages of low toxicity, multi-target and multi-pathway action. It has been reported that polysaccharides can affect the gut–liver axis at multiple interrelated levels, such as maintaining the ecological balance of gut microbiota (GM), regulating the metabolites of GM and improving the intestinal barrier function, which thereby plays a protective role in NAFLD. These studies have great scientific significance in understanding NAFLD based on the gut–liver axis and developing safe and effective medical treatments. Herein, we reviewed the recent progress of polysaccharides in improving nonalcoholic fatty liver disease (NAFLD) through the gut–liver axis.

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“…[21][22][23] Drugs loaded onto biomaterials generally exhibit large loading capacity, controllable drug release, and improved drug bioavailability, which are beneficial for maximizing their therapeutic efficacy. [18,24,25] Among these biomaterials, silk sericin (SS), a globular water-soluble protein derived from cocoons, has been shown to be an excellent bioactive natural carrier for fabricating advanced drug delivery systems. [26,27] In addition to serving as a drug carrier, SS exhibits intrinsic biological activities, such as cellular adhesion and proliferation activity, antioxidant, and anti-tyrosine properties, which can synergize with various drugs and optimize their efficacy.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential Evaluation of Silk Sericin Stabilized Fisetin to Ulcerative Colitis

Wang,

Xiang,

et al. 2023

Macromolecular Bioscience

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Ulcerative colitis is a chronic inflammatory bowel disease with a high recurrence rate. Natural phytochemical compounds are increasingly being considered as preventative and supportive treatments for this condition. However, the poor water solubility and stability of many of these compounds limit their effectiveness in vivo. To address this issue, fisetin (FT), a natural phytochemical with poor solubility, was stabilized using silk sericin (SS) to create a composite (SS/FT). The therapeutic potential of the SS/FT on ulcerative colitis was extensively investigated, and the results showed that it effectively alleviated the body weight loss and colon length shortening induced by dextran sulfate sodium. Notably, SS/FT downregulated the immune response, decreased colonic histopathological lesions, and reduced the cGAS/STING signal activation. This suggests that SS/FT may offer a promising therapy for treating ulcerative colitis.This article is protected by copyright. All rights reserved

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The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis

Cited by 12 publications

References 84 publications

Protective Effects of Different Molecular Weights of Purslane (Portulaca oleracea L.) Aqueous Extract on DSS-Induced Ulcerative Colitis in Mice

Protective Effects of Different Molecular Weights of Purslane (Portulaca oleracea L.) Aqueous Extract on DSS-Induced Ulcerative Colitis in Mice

Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis

Therapeutic Potential Evaluation of Silk Sericin Stabilized Fisetin to Ulcerative Colitis

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