The function of redox shuttles during aerobic glycolysis in two strains of Ehrlich ascites tumor cells

Plasma membrane redox system activity in tumour cell lines of mammary origins with different proliferation rates

“…1988c). As it is shown in Table 4, the endogenous content of lactate was much higher in Cbm cells than (S~inchez-Jim6nez et al 1985). It is noteworthy that the difference observed in lactate consumption rates is the same as that observed in ferricyanide reduction rates.…”

Finding an “Achilles’ heel” of cancer: The role of glucose and glutamine metabolism in the survival of transformed cells

“…Expression and activity of the enzymes regulating the flux of glucose and glutamine through these pathways are altered in tumors and often correlate with the rate of tumor proliferation and the degree of tumor dedifferentiation. [21][22][23][24][25][26] The changes in glucose and glutamine metabolism of tumor cells and interaction between these processes vary among tumor types 15,27 as well as among proliferation and differentiation states of tumors. 25,[28][29][30] They can be dependent on tumor microenvironment 31,32 and can be the result of selection for cells able to survive under unfavorable conditions.…”

Studies on the mechanism by which glutamine and heat shock increase lactate synthesis by l929 cells in the presence of insulin

“…Cytoplasmically generated reducing equivalents are translocated into mitochondria by means of the malate- aspartate shuttle as diagrammed in Figure 2 (Williamson et al, 1973). Since cytosolic and intramitochondrial transaminations are involved in each cycle of the malate-aspartate shuttle, transaminase inhibitors have been useful in establishing the existence of this pathway and its direction in many systems (e.g., Greenhouse and Lehninger, 1976;Sanchez-Jimenez et al, 1985). If lactate synthesis is increased by blocking the shuttle, then net reducing equivalent flux is from cytoplasm to mitochondria.…”