The function of <scp>SEC22B</scp> and its role in human diseases

Wei, Sun; Tian, Bixia; Wang, Shuhong; Liu, Peijun; Wang, Yao-Chun

doi:10.1002/cm.21628

Cited by 25 publications

(21 citation statements)

References 106 publications

(138 reference statements)

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“…Table 5B). Interestingly, SNARE protein SEC22B has been shown to modulate many pathological and physiological processes including autophagy, vesicle trafficking, neurodegeneration, cancers as well as infectious diseases (Sun et al, 2020). SEC22B is closely related to tumorigenesis and has been confirmed in numerous cancers including lung, breast, prostate, and uterine cancers (Gao et al, 2013), and furthermore, SEC22B has been shown to fuse with NOTCH2 and was confirmed in aggressive breast cancer (Veeraraghavan et al, 2016).…”

Section: Our Novel Findings Are Further Validated By Omics Datamentioning

confidence: 99%

CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women

Abou‐Fadel

Grajeda

Jiang

et al. 2022

CBM

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Breast cancer is the most diagnosed cancer worldwide and remains the second leading cause of cancer death. While breast cancer mortality has steadily declined over the past decades through medical advances, an alarming disparity in breast cancer mortality has emerged between African American women (AAW) and Caucasian American women (CAW). New evidence suggests more aggressive behavior of triple-negative breast cancer (TNBC) in AAW may contribute to racial differences in tumor biology and mortality. Progesterone (PRG) can exert its cellular effects through either its classic, non-classic, or combined responses through binding to either classic nuclear PRG receptors (nPRs) or non-classic membrane PRG receptors (mPRs), warranting both pathways equally important in PRG-mediated signaling. In our previous report, we demonstrated that the CCM signaling complex (CSC) consisting of CCM1, CCM2, and CCM3 can couple both nPRs and mPRs signaling cascades to form a CSC-mPRs-PRG-nPRs (CmPn) signaling network in nPR positive(+) breast cancer cells. In this report, we furthered our research by establishing the CSC-mPRs-PRG (CmP) signaling network in nPR(-) breast cancer cells, demonstrating that a common core mechanism exists, regardless of nPR(+⁣/⁣-) status. This is the first report stating that inducible expression patterns exist between CCMs and major mPRs in TNBC cells. Furthermore, we firstly show mPRs in TNBC cells are localized in the nucleus and participate in nucleocytoplasmic shuttling in a coordinately synchronized fashion with CCMs under steroid actions, following the same cellular distribution as other well-defined steroid hormone receptors. Finally, for the first time, we deconvoluted the CmP signalosome by using systems biology and TNBC clinical data, which helped us understand key factors within the CmP network and identify 6 specific biomarkers with potential clinical applications associated with AAW-TNBC tumorigenesis. These novel biomarkers could have immediate clinical implications to dramatically improve health disparities among AAW-TNBCs.

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Section: Our Novel Findings Are Further Validated By Omics Datamentioning

confidence: 99%

CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women

Abou‐Fadel

Grajeda

Jiang

et al. 2022

CBM

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“… Horikoshi et al (2013 ) reported that variants in ADCY5 were associated with lower birth weight in the European population, implying that ADCY5 may be linked to a poor maternal–fetal environment. Furthermore, SEC22A, also known as a vesicle-trafficking protein SEC22 homolog B, is involved in vesicle trafficking and regulates multiple signaling and transportation pathways ( Sun et al, 2020 ). In an animal model, SEC22A was found to be over-expressed in immature oocytes compared to matured counterparts, indicating a potential effect of SEC22A in oocyte growth and maturation ( Mamo et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetes

Han

et al. 2022

Front. Genet.

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Genome-wide association studies (GWAS) have identified several common variants associated with polycystic ovary syndrome (PCOS). However, the etiology behind PCOS remains incomplete. Available evidence suggests a potential genetic correlation between PCOS and type 2 diabetes (T2D). The publicly available data may provide an opportunity to enhance the understanding of the PCOS etiology. Here, we quantified the polygenic overlap between PCOS and T2D using summary statistics of PCOS and T2D and then identified the novel genetic variants associated with PCOS behind this phenotypic association. A bivariate causal mixture model (MiXeR model) found a moderate genetic overlap between PCOS and T2D (Dice coefficient = 44.1% and after adjusting for body mass index, 32.1%). The conditional/conjunctional false discovery rate method identified 11 potential risk variants of PCOS conditional on associations with T2D, 9 of which were novel and 6 of which were jointly associated with two phenotypes. The functional annotation of these genetic variants supports a significant role for genes involved in lipid metabolism, immune response, and the insulin signaling pathway. An expression quantitative trait locus functionality analysis successfully repeated that 5 loci were significantly associated with the expression of candidate genes in many tissues, including the whole blood, subcutaneous adipose, adrenal gland, and cerebellum. We found that SCN2A gene is co-localized with PCOS in subcutaneous adipose using GWAS-eQTL co-localization analyses. A total of 11 candidate genes were differentially expressed in multiple tissues of the PCOS samples. These findings provide a new understanding of the shared genetic architecture between PCOS and T2D and the underlying molecular genetic mechanism of PCOS.

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“…No specific association with cancer-related processes has been reported to date for this gene; however, it has been demonstrated that vesicle trafficking plays a crucial role in tumorigenesis [47]. Moreover, its homolog SEC22B (SEC22 homolog B, vesicle trafficking protein) is involved in carcinogenesis and harbors several mutations associated with different cancer models [48]. VAMP3 (vesicle associated membrane protein 3) encodes a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and is involved in integrin trafficking and cell migration.…”

Section: Discussionmentioning

confidence: 99%

“…For the migration assay, cells (1 × 10 4 per well) were seeded, and reverse transfected in an Oris Cell Migration Assay 96-well plate after insertion of Oris Cell Seeding Stoppers. Stoppers were removed 24 h after transfection (T0) and migration was evaluated at different time points (24,48,72,96, and 144 h after stopper removal). Cells migrated in the detection zone were quantified by using ImageJ software.…”

mentioning

confidence: 99%

LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network

Barbagallo

Caltabiano

Broggi

et al. 2020

Cancers

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Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults; little is known about the contribution of non-coding RNAs (ncRNAs) to UM pathogenesis. Competitive endogenous RNA (ceRNA) networks based on RNA–RNA interactions regulate physiological and pathological processes. Through a combined approach of in silico and experimental biology, we investigated the expression of a set of long non-coding RNAs (lncRNAs) in patient biopsies, identifying LINC00518 as a potential oncogene in UM. The detection of LINC00518 dysregulation associated with several in vitro functional assays allowed us to investigate its ceRNA regulatory network and shed light on its potential involvement in cancer-related processes, such as epithelial to mesenchymal transition (EMT) and CoCl2-induced hypoxia-like response. In vitro transient silencing of LINC00518 impaired cell proliferation and migration, and affected mRNA expression of LINGO2, NFIA, OTUD7B, SEC22C, and VAMP3. A “miRNA sponge” and “miRNA protector” model have been hypothesized for LINC00518-induced regulation of mRNAs. In vitro inhibition of MITF suggested its role as a potential activator of LINC00518 expression. Comprehensively, LINC00518 may be considered a new oncogene in UM and a potential target for RNA-based therapeutic approaches.

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The function of SEC22B and its role in human diseases

Cited by 25 publications

References 106 publications

CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women

CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women

Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetes

LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network

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