The function of terpene natural products in the natural world

Gershenzon, Jonathan; Dudareva, Natalia

doi:10.1038/nchembio.2007.5

Cited by 1,709 publications

(1,262 citation statements)

References 91 publications

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“…Antagonistic effects can occur, for example, when one compound alters a structure that is a target of a second compound, or interferes with the production of a second compound's target (Jia et al., 2009). Other mechanisms may include reduced uptake or stimulation of detoxification (Gershenzon & Dudareva, 2007). An example of antagonistic effects is the coprecipitation of tomato leaf saponins and phytosterols.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of floral phytochemicals against a bumble bee parasite

Palmer‐Young¹,

Sadd

Irwin

et al. 2017

Ecology and Evolution

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Floral landscapes comprise diverse phytochemical combinations. Individual phytochemicals in floral nectar and pollen can reduce infection in bees and directly inhibit trypanosome parasites. However, gut parasites of generalist pollinators, which consume nectar and pollen from many plant species, are exposed to phytochemical combinations. Interactions between phytochemicals could augment or decrease effects of single compounds on parasites. Using a matrix of 36 phytochemical treatment combinations, we assessed the combined effects of two floral phytochemicals, eugenol and thymol, against four strains of the bumblebee gut trypanosome Crithidia bombi. Eugenol and thymol had synergistic effects against C. bombi growth across seven independent experiments, showing that the phytochemical combination can disproportionately inhibit parasites. The strength of synergistic effects varied across strains and experiments. Thus, the antiparasitic effects of individual compounds will depend on both the presence of other phytochemicals and parasite strain identity. The presence of synergistic phytochemical combinations could augment the antiparasitic activity of individual compounds for pollinators in diverse floral landscapes.

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Section: Introductionmentioning

confidence: 99%

Synergistic effects of floral phytochemicals against a bumble bee parasite

Palmer‐Young¹,

Sadd

Irwin

et al. 2017

Ecology and Evolution

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“…They are effective against non adapted specialist herbivores (Sorensen et al, 2005), and generalist herbivores (Mihaliak et al, 1987;Landau et al, 1994;Mote et al, 2007). Moreover, terpenoids have many other protective properties such as defense against fungi and pathogens (Gershenzon and Duradeva, 2007), and against abiotic stresses such as high temperature, drought, ozone, or excess radiation Llusià, 2003, 2004).…”

Section: Introductionmentioning

confidence: 99%

Higher Allocation to Low Cost Chemical Defenses in Invasive Species of Hawaii

et al. 2010

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The capacity to produce carbon-based secondary compounds (CBSC), such as phenolics (including tannins) and terpenes as defensive compounds against herbivores or against neighboring competing plants can be involved in the competition between alien and native plant species. Since the Hawaiian Islands are especially vulnerable to invasions by alien species, we compared total phenolic (TP), total tannin (Tta), and total terpene (TT) leaf contents of alien and native plants on Oahu Island (Hawaii). We analyzed 35 native and 38 alien woody plant species randomly chosen among representative current Hawaiian flora. None of these CBSC exhibited phylogenetic fingerprinting. Alien species had similar leaf TP and leaf Tta contents, and 135% higher leaf TT contents compared with native species. Alien plants had 80% higher leaf TT:N leaf content ratio than native plants. The results suggest that apart from greater growth rate and greater nutrient use, alien success in Oahu also may be linked to greater contents of low cost chemical defenses, such as terpenes, as expected in faster-growing species in resource rich regions. The higher TT contents in aliens may counterbalance their lower investment in leaf structural defenses and their higher leaf nutritional quality. The higher TT provides higher effectiveness in deterring the generalist herbivores of the introduced range, where specialist herbivores are absent. In addition, higher TT contents may favor aliens conferring higher protection against abiotic and biotic stressors. The higher terpene accumulation was independent of the alien species origin, which indicates that being alien either selects for higher terpene contents post-invasion, or that species with high terpene contents are pre-adapted to invasiveness. Although less likely, an originally lower terpene accumulation in Hawaiian than in continental plants that avoids the increased attraction of specialist enemies associated to terpenes may not be discarded.

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“…Our results provide a foundation for future investigations on the relationships between terpene profiles and the attack of this fungus in order to characterize less susceptible Norway spruce chemotypes. Besides, a more comprehensive understanding of the function of antifungal properties of Norway spruce resin, requires knowledge of the defensive roles of sesquiterpenes and diterpenes and other compounds as phenols (Gershenzon and Dudareva, 2007).…”

Section: Tablementioning

confidence: 99%

“…In conifers, induced stress responses include changes in anatomy and woody phloem as well as changes in the composition and flow of resins (Sancho-Knapik et al, 2017;Gershenzon and Dudareva, 2007;Phillips and Croteau, 1999). Resins are complex mixtures of different classes of terpenoids containing the concentrations of monoterpenoids and diterpene acids, and small quantities of sesquiterpenoids (Langenheim, 1994).…”

Section: Introductionmentioning

confidence: 99%

Monoterpene responses to interacting effects of drought stress and infection by the fungus Heterobasidion parviporum in two clones of Norway spruce (Picea abies)

Madmony

Tognetti

Zamponi

et al. 2018

Environmental and Experimental Botany

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A B S T R A C TTo study simultaneous biotic and abiotic stress effects on monoterpene mediated defence response, four-year-old seedlings of two clones of Picea abies (c386: "relatively resistant" c386; c171: "relatively susceptible" clone 171) were inoculated with an isolate of rot fungus Heterobasidion parviporum and simultaneously subjected to a drought stress recovery cycle. Fungal growth into the wood was generally higher in well-watered (W) than in drought-stressed (D) plants. As predawn water potential decreased, gas exchange and maximal photochemical efficiency of PSII also declined. Water potential and chlorophyll fluorescence showed differences between clones in D plants, c386 being more tolerant than c171, while stomatal conductance and net photosynthesis differed between clones in W plants; c171 showing higher values than c386. A recovery of physiological functions was observed after re-watering. The clones showed different constitutive monoterpene profiles. The infection generally caused some extensive compositional changes in the relative contents of several monoterpenes and their enantiomers; also, sterile infection (wounded only samples) affected the relative proportions of monoterpenes, although to a lesser extent than reactions elicited by the fungus. The trend in monoterpene response to disease treatments was the same in D and W plants of both clones. In particular, higher proportion of δ-3-carene was found constitutively in c386 in comparison with c171; besides, infection with H. parviporum increased the relative contents of δ-3-carene in all the samples, even if proportions of this monoterpene in wounded plus inoculated tissues of c386 were significantly higher than cortical tissues from non-inoculated branches only in W seedlings 44 days after treatment.Although drought stress decreased the total absolute contents of monoterpenes, total monoterpene concentrations significantly increased in response to infection by H. parviporum.

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The function of terpene natural products in the natural world

Cited by 1,709 publications

References 91 publications

Synergistic effects of floral phytochemicals against a bumble bee parasite

Synergistic effects of floral phytochemicals against a bumble bee parasite

Higher Allocation to Low Cost Chemical Defenses in Invasive Species of Hawaii

Monoterpene responses to interacting effects of drought stress and infection by the fungus Heterobasidion parviporum in two clones of Norway spruce (Picea abies)

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