The function of γδ T cells in humoral immune responses

Qiu, Ling; Zhang, Yixi; Zeng, Xun

doi:10.1007/s00011-023-01704-4

Cited by 2 publications

(1 citation statement)

References 72 publications

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“…1006,1007 γδ T cells participate in humoral immunity by promoting B cell maturation, antibody production and class switching. 1008 γδ T cells also modulate αβ T-cell activity indirectly through activating NK cells, DCs and B cells. 1002 Intriguingly, γδ T cells are recently unveiled a critical role in mediating immune response to ICB in MHC I-deficient cancers, in which PD-1 + Vδ1 and Vδ3 T cells are the main contributors.…”

Section: γδ T Cells In Tumor Immunitymentioning

confidence: 99%

T cells in health and disease

Sun,

Su,

Jiao

et al. 2023

Sig Transduct Target Ther

234

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T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and mainly generates CD4+ and CD8+ T cell subsets. Upon antigen stimulation, naïve T cells differentiate into CD4+ helper and CD8+ cytotoxic effector and memory cells, mediating direct killing, diverse immune regulatory function, and long-term protection. In response to acute and chronic infections and tumors, T cells adopt distinct differentiation trajectories and develop into a range of heterogeneous populations with various phenotype, differentiation potential, and functionality under precise and elaborate regulations of transcriptional and epigenetic programs. Abnormal T-cell immunity can initiate and promote the pathogenesis of autoimmune diseases. In this review, we summarize the current understanding of T cell development, CD4+ and CD8+ T cell classification, and differentiation in physiological settings. We further elaborate the heterogeneity, differentiation, functionality, and regulation network of CD4+ and CD8+ T cells in infectious disease, chronic infection and tumor, and autoimmune disease, highlighting the exhausted CD8+ T cell differentiation trajectory, CD4+ T cell helper function, T cell contributions to immunotherapy and autoimmune pathogenesis. We also discuss the development and function of γδ T cells in tissue surveillance, infection, and tumor immunity. Finally, we summarized current T-cell-based immunotherapies in both cancer and autoimmune diseases, with an emphasis on their clinical applications. A better understanding of T cell immunity provides insight into developing novel prophylactic and therapeutic strategies in human diseases.

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Section: γδ T Cells In Tumor Immunitymentioning

confidence: 99%

T cells in health and disease

Sun,

Su,

Jiao

et al. 2023

Sig Transduct Target Ther

234

View full text Add to dashboard Cite

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Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations

et al. 2023

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Vaccine efficacy determined within the controlled environment of a clinical trial is usually substantially greater than real-world vaccine effectiveness. Typically, this results from reduced protection of immunologically vulnerable populations, such as children, elderly individuals and people with chronic comorbidities. Consequently, these high-risk groups are frequently recommended tailored immunisation schedules to boost responses. In addition, diverse groups of healthy adults may also be variably protected by the same vaccine regimen. Current population-based vaccination strategies that consider basic clinical parameters offer a glimpse into what may be achievable if more nuanced aspects of the immune response are considered in vaccine design. To date, vaccine development has been largely empirical. However, next-generation approaches require more rational strategies. We foresee a generation of precision vaccines that consider the mechanistic basis of vaccine response variations associated with both immunogenetic and baseline health differences. Recent efforts have highlighted the importance of balanced and diverse extra-neutralising antibody functions for vaccine-induced protection. However, in immunologically vulnerable populations, significant modulation of polyfunctional antibody responses that mediate both neutralisation and effector functions has been observed. Here, we review the current understanding of key genetic and inflammatory modulators of antibody polyfunctionality that affect vaccination outcomes and consider how this knowledge may be harnessed to tailor vaccine design for improved public health.

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The function of γδ T cells in humoral immune responses

Cited by 2 publications

References 72 publications

T cells in health and disease

T cells in health and disease

Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations

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