The functional neuroanatomy of bipolar disorder

Cerullo, Michael A.; Adler, Caleb M.; DelBello, Melissa P.; Strakowski, Stephen M.

doi:10.1080/09540260902962107

Cited by 104 publications

(88 citation statements)

References 33 publications

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“…However, there were also two regions that had a stronger relationship between these imaging modalities in the bipolar versus healthy control group (i.e., coupling was enhanced), the left temporal pole and left inferior temporal gyrus. Many of these regions have been previously implicated by functional imaging studies as having a role in bipolar disorder (Cerullo, Adler, Delbello, & Strakowski, 2009; Gruber, Rogowska, & Yurgelun‐Todd, 2004; Keener & Phillips, 2007; Maletic & Raison, 2014; Strakowski et al., 2011; Townsend et al., 2012; Whitton, Treadway, & Pizzagalli, 2015; Yoshimura et al., 2014), which suggests that the altered relationship between fT1ρ and BOLD is related to the illness. For instance, numerous studies have shown that functional activity in the striatum is altered in bipolar disorder during the completion of reward tasks (Caseras, Lawrence, Murphy, Wise, & Phillips, 2013; Whitton et al., 2015; Yip, Worhunsky, Rogers, & Goodwin, 2014) and reduced during fear perception tasks (Killgore, Gruber, & Yurgelun‐Todd, 2008).…”

Section: Discussionmentioning

confidence: 99%

Relationship altered between functional T1ρ and BOLD signals in bipolar disorder

et al. 2017

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IntroductionFunctional neuroimaging typically relies on the blood‐oxygen‐level–dependent (BOLD) contrast, which is sensitive to the influx of oxygenated blood following neuronal activity. A new method, functional T1 relaxation in the rotating frame (fT1ρ) is thought to reflect changes in local brain metabolism, likely pH, and may more directly measure neuronal activity. These two methods were applied to study activation of the visual cortex in participants with bipolar disorder as compared to controls.MethodsThirty‐nine participants with bipolar disorder and 32 healthy controls underwent functional neuroimaging during a flashing checkerboard paradigm. Functional images were acquired in alternating blocks of BOLD and fT1ρ. Linear mixed‐effect models were used to examine the relationship between these two functional imaging modalities and to test whether that relationship was altered in bipolar disorder.Results BOLD and fT1ρ signal were strongly related in visual and cerebellar areas during the task in controls. The relationship between these two measures was reduced in bipolar disorder within the visual areas, cerebellum, striatum, and thalamus.ConclusionsThese results support a distinct mechanisms underlying BOLD and fT1ρ signals. The weakened relationship between these imaging modalities may provide a novel tool for measuring pathology in bipolar disorder and other psychiatric illnesses.

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Section: Discussionmentioning

confidence: 99%

Relationship altered between functional T1ρ and BOLD signals in bipolar disorder

et al. 2017

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“…Prescribed social interactions along with conventional medication enhance the longterm outcomes [227]. Interactive contributions of genetic, neurobiological, and psychosocial factors are involved in therapeutic regime of BD [224].…”

Section: Bipolar Disorder and Related Psychobehavioural Anomaliesmentioning

confidence: 99%

“…The occupational and social dysfunction is evident through signs of depressive symptoms, excessive alcohol use, anxiety, abnormal symptoms and degraded socioeconomic status [227]. Functional impairment can be seen between episodes and most frequently in case of subsyndromal depressive symptoms [228,223].…”

Section: Bipolar Disorder and Related Psychobehavioural Anomaliesmentioning

confidence: 99%

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Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury¹,

Sahu²,

Ramanujam³

et al. 2018

Neuropsychiatry

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Structural changes in different regions of the brain have become clinically relevant and regarded as the signature phenomenon for neurological diseases. Morphological changes in brain are also associated with neuronal and neurochemical alterations. Studies have showed that minute changes in neurochemical levels may have marked impact on the psychobehaviour of the subject. Several neurological disease profiles have been reported with such specific psychobehavioural expression. However, application of behavioural abnormalities as possible disease progress markers has not been considered and emphasised much. Reports suggested that-the subjects, who have already entered into the terminal stage of the disease, used to show cardinal behavioural signs for a specific disease profile. However, psychological expressions are comparatively early expressive. As most of the neurodegenerative disorders are unidirectional and progressive by nature, therapeutic intervention at the right time is essential for attaining the desired outcome. Moreover, early diagnosis can aid in managing the disease progression also. Psychobehavioural analysis could meet the expected outcome of disease diagnosis if implemented properly and timely. In the present review, we have amalgamated the reported behavioural anomalies with the supportive background from neurochemical basis. Further, we have concluded that behaviour centric studies could be a potential diagnostic tool for the early diagnosis of major neurological diseases such as Alzheimer disease, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), Bipolar disorder, Schizophrenia, Impulse control disorder (ICD) and Obsessive-compulsive disorder (OCD).

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“…The task was chosen as it has been shown to differentiate BD patients and those at increased familial risk for the disorder from healthy controls with respect to differing brain activation patterns (McIntosh et al, 2008b;Whalley et al, 2011). It has also been found to activate left superior and middle prefrontal regions (Allen et al, 2010), anterior cingulate areas (NathanielJames et al, 1997), as well as the striatum (McIntosh et al, 2008b), which are considered to be involved in the pathophysiology of BD (Strakowski et al, 2005;Cerullo et al, 2009). Moreover, it probes neuropsychological deficits in verbal initiation and verbal fluency commonly observed in BD (Arts et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of Variation in Diacylglycerol Kinase Eta (DGKH) Gene on Brain Function in a Cohort at Familial Risk of Bipolar Disorder

Whalley

Papmeyer

Romaniuk

et al. 2011

Neuropsychopharmacol

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Several lines of evidence indicate that the diacylglycerol kinase eta (DGKH) gene is implicated in the etiology of bipolar disorder (BD). However, the functional neural mechanisms of DGKH's risk association remain unknown. Therefore, we examined the effects of three haplotype-tagging risk variants in DGKH (single nucleotide polymorphisms rs9315885, rs1012053, and rs1170191) on brain activation using a verbal fluency functional magnetic resonance imaging task. The subject groups consisted of young individuals at high familial risk of BD (n ¼ 81) and a comparison group of healthy controls (n ¼ 75). Individuals were grouped based on risk haplotypes described in previous studies. There was a significant risk haplotype * group interaction in the left medial frontal gyrus (BA10, involving anterior cingulate BA32), left precuneus, and right parahippocampal gyrus. All regions demonstrated greater activation during the baseline condition than sentence completion. Individuals at high familial risk for BD homozygous for the DGKH risk haplotype demonstrated relatively greater activation (poor suppression) of these regions during the task vs the low-risk haplotype subjects. The reverse pattern was seen for the control subjects. These findings suggest that there are differential effects of the DGKH gene in healthy controls vs the bipolar high-risk group, which manifests as a failure to disengage default-mode regions in those at familial risk carrying the risk haplotype.

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The functional neuroanatomy of bipolar disorder

Cited by 104 publications

References 33 publications

Relationship altered between functional T1ρ and BOLD signals in bipolar disorder

Relationship altered between functional T1ρ and BOLD signals in bipolar disorder

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Effect of Variation in Diacylglycerol Kinase Eta (DGKH) Gene on Brain Function in a Cohort at Familial Risk of Bipolar Disorder

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