2023
DOI: 10.3390/v16010027
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The Functional Roles of MDSCs in Severe COVID-19 Pathogenesis

Jia Len,
Clara Koh,
Kuan Chan

Abstract: Severe COVID-19 is a major cause of morbidity and mortality worldwide, especially among those with co-morbidities, the elderly, and the immunocompromised. However, the molecular determinants critical for severe COVID-19 progression remain to be fully elucidated. Meta-analyses of transcriptomic RNAseq and single-cell sequencing datasets comparing severe and mild COVID-19 patients have demonstrated that the early expansion of myeloid-derived suppressor cells (MDSCs) could be a key feature of severe COVID-19 prog… Show more

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Cited by 4 publications
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“…MDSCs can also produce reactive oxygen species (ROS) such as superoxide through NADPH oxidase 2 (NOX2). 36 Consequently, all of the results together suggest that MCEMP1 may be a key molecule in the regulation and maintenance of the bacterial or viral sepsis and it was worthy of additional investigation and development.…”
Section: Mcemp1mentioning
confidence: 99%
“…MDSCs can also produce reactive oxygen species (ROS) such as superoxide through NADPH oxidase 2 (NOX2). 36 Consequently, all of the results together suggest that MCEMP1 may be a key molecule in the regulation and maintenance of the bacterial or viral sepsis and it was worthy of additional investigation and development.…”
Section: Mcemp1mentioning
confidence: 99%