The functional status of ESRD patients as measured by the sickness impact profile

Hart, L. Gary; Evans, Roger W.

doi:10.1016/s0021-9681(87)80041-3

Cited by 125 publications

(47 citation statements)

References 13 publications

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“…The majority of patients (77%) rated 1 or 2 on the 7-point scale for overall life satisfaction. Similar observations were made before in renal (2> [15][16][17] and liver transplant patients (20,21). The favorable scores in these patient groups have been attributed to the feeling of being reborn after transplantation, to the desire to fulfill certain expectations, and to psychological defense mecha nisms against fear for rejection and complications (21).…”

Section: Discussionsupporting

confidence: 69%

“…Previous, cross-sectional studies established a higher quality of life in transplanted patients when compared with patients on hemodialysis or continuous ambulatory peritoneal dialysis (15)(16)(17), while a few prospective studies have reported a rise in health status after successful transplantation (18,19). Our results indicate that the figures obtained in renal graft recipients depend on the time elapsed after transplantation.…”

Section: Discussionsupporting

confidence: 44%

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The Effect of Immunosuppressive Drugs on Quality of Life After Renal Transplantation

Hilbrands

Hoitsma²,

Koene³

1995

Transplantation

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This prospective, randomized study investigates the effect of two immunosuppressive treatment regimens on quality of life after renal transplantation. At 3 months after transplantation, patients treated with cyclosporine (CsA) and prednisone (Pred) were allo cated to either withdrawal of Pred (n=60) or to con version of CsA to azathioprine (Aza) (Aza-Pred, n=60). Quality of life was evaluated just before randomiza tion, and at 6 and 12 months after transplantation using the Sickness Impact Profile (SIP), the Affect Bal ance Scale (ABS), the Center for Epidemiological Stud ies Depression Scale (CES-D), measures of satisfaction with several domains o f life experience, and a popula tion-specific physical symptoms questionnaire. In both groups, the overall SIP score as well as the scores on its physical and psychosocial dimensions improved continuously after transplantation, reaching levels that are comparable to those found in the general population. The occurrence of acute or chronic rejec tion had a significantly negative effect on SIP and CES-D scores. Intention-to-treat analysis showed no differences between groups for scores on SIP, ABS, CES-D, and satisfaction measures. Exclusion of 41 pa tients who did n ot strictly adhere to their originally designated therapy showed a tendency for better psy chosocial SIP scores in CsA patients (P=0.05), which mainly resulted from a difference on the category of social interaction (P-0,01). This difference occurred despite a similar rejection rate and worse renal func tion in CsA-treated patients. Shortly after steroid withdrawal, a high proportion of CsA patients com plained of stiff or painful muscles (CsA: 74%, Aza-Pred: 36%; P = 0.002). Our data indicate that if successfully completed, CsA monotherapy from 3 months after transplantation may lead to a higher degree of psycho social well-being as compared with conversion from CsA-Pred to Aza-Pred. It seems likely that this advan tage is related to the withdrawal of Pred.One of the primary goals of renal transplantation is to improve the quality of life of the patient with end-stage renal disease. Traditional research efforts, however, have mainly been directed at prolonging patient and graft survival. These survival rates have improved considerably during the last decades and any further progress will be hard to achieve. Therefore, it is not surprising that the quality of life of the patients with prolonged survival is receiving a growing amount of attention (i, 2).The type of immunosuppressive drug therapy is one of the factors that determine the quality of life after renal trans plantation. First, an effective immunosuppressive regimen, leading to prolonged patient and graft survival, is a prereq uisite to reach an optimal level of quality of life. Besides, treatment schedules may act more directly on quality of life by means of their adverse effects, which will differ according to the drugs that are used. Patients' psychosocial function ing, which they will partly attribute to prescribed medica tion, will in turn hav...

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 44%

The Effect of Immunosuppressive Drugs on Quality of Life After Renal Transplantation

Hilbrands

Hoitsma²,

Koene³

1995

Transplantation

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“…B consisted of kidney transplant patients with functioning grafts {n = 144. 81 men and 63 women, mean age 37-2 years) [15]. C was a group of patients with rheumatic disorders, such as rheumatoid arthritis, polyarthritis and osteoarthritis (n= 147. women, age range from 38 to 72 years) [I6|.…”

Section: Rclcrcncc Groupsmentioning

confidence: 99%

The life situations of patients with primary antibody deficiency untreated or treated with subcutaneous gammaglobulin infusions

Gardulf

Björvell

Gustafson

et al. 1993

Clinical and Experimental Immunology

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SUMMARYThe life situations of 25 patients with hypogammaglobulinaemia were studied before and after the initiation of subcutaneous replacement therapy by using medical records, data registers and questionnaires (a study and a disease-specific questionnaire, the Sickness Impaet Profile and the General Health Rating Index). Before treatment, the patients perceived more dysfunctions with regard to ambulation. mobility, emotional behaviour, social interaction, sleep and rest, household management, work and recreation or pastime activities compared with a Swedish reference group (/' = O-OOOI). Asignilicant increase in the perceived frequency of infections was also seen in untreated patients compared with a group of healthy individuals (/' = OOOOI). After 18 months of weekly subcutaneous infusions of an intramuscular gammaglobulin preparation (100 mg/kg). the patients reported a significantly increased, health-related function and improved self-rated health. A significantly higher pre-infusion IgG level was also Ibund.Keywords hypogammaglobulinaemia gammaglobulin treatment quality of life health

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“…An additional source of heterogeneity is that the indications for home haemodialysis may have altered over the period during which the included studies were published. A meta-analysis was not undertaken, in order to avoid generating a spuriously precise overall estimate of effect around results that might be potentially biased.Although a number of studies gave details of the distribution of co-morbidities between the participant groups, [17][18][19]21,22,24,28,31,33,36 in no study were all co-morbidities approximately balanced between groups. Generally, the percentage of home haemodialysis participants with specific co-morbidities was lower than the percentage of people in the hospital/satellite unit group with those co-morbidities, introducing further potential for confounding.…”

mentioning

confidence: 99%

Systematic review of the effectiveness and cost-effectiveness, and economic evaluation, of home versus hospital or satellite unit haemodialysis for people with end-stage renal failure

Mowatt

Vale

Perez

et al. 2003

Health Technol Assess

168

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The functional status of ESRD patients as measured by the sickness impact profile

Cited by 125 publications

References 13 publications

The Effect of Immunosuppressive Drugs on Quality of Life After Renal Transplantation

The Effect of Immunosuppressive Drugs on Quality of Life After Renal Transplantation

The life situations of patients with primary antibody deficiency untreated or treated with subcutaneous gammaglobulin infusions

Systematic review of the effectiveness and cost-effectiveness, and economic evaluation, of home versus hospital or satellite unit haemodialysis for people with end-stage renal failure

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