The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

Gb, Fedoseev

doi:10.15406/jlprr.2018.05.00162

JLPRR

2018

DOI: 10.15406/jlprr.2018.05.00162

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The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

Fedoseev Gb¹

Abstract: To study the functional state of neutrophils in patients with bronchial asthma, bronchial asthma + COPD, COPD and community-acquired pneumonia to expand diagnosis, to determine the individual characteristics of the patients of the studied groups and choose the optimal methods of treatment.

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Cited by 2 publications

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Seasonality in testing and positive respiratory bacterial infections in the Australian Capital Territory, 1997–2007

Liu

Lal

2021

Commun Dis Intell

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Background Chlamydia pneumoniae (Cp) and Mycoplasma pneumoniae (Myco) bacteria are atypical pathogens that can cause pneumonia and exacerbate underlying conditions such as asthma and chronic obstructive pulmonary disease. In the Australian Capital Territory, there is limited information on how seasonal patterns for positive infections and testing may vary, a gap that has implications for control strategies. Methods We examined seasonal patterns of immunoassay results of patients from Canberra Hospital, Australia, who were tested for Cp and/or Myco. Pathology data, collected from August 1997 to March 2007 from 7,275 patients, were analysed with time series additive decomposition and time series regression. Results The proportion of positive Cp infections was highest in March and April (autumn) and lowest in June and August (winter). The proportion of positive Myco infections was highest in December and January (summer) and lowest in August (winter), even though testing for the pathogen peaked in winter with a low in summer. Models with a long-term trend and a variable for month were a better fit for the data than the null models for both infections. Conclusion We found differences in seasonal patterns of testing and in the proportion of positive infections. These findings suggest that preventative measures for common infections need to account for seasonal testing practices so as to build an accurate picture of temporal changes in these infections.

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Seasonality in testing and positive respiratory bacterial infections in the Australian Capital Territory, 1997–2007

Liu

Lal

2021

Commun Dis Intell

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Indicators of the cytokine profile and standard immunogram in the controlled and uncontrolled course of bronchial asthma in children

Suprun,

Kozlov

et al. 2024

Russian Journal of Immunology

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Bronchial asthma in children is a multifactorial disease, but it is based on atopic inflammation, which is the focus of the main methods of research and therapy of this pathology. However, if we evaluate not only the fact of the appearance of bronchial asthma in a particular patient, but also consider its course in more detail, and especially the possibility of achieving control over the disease, then indicators of not only atopic inflammation, but also local inflammation in general, acquire great influence, which is one of the reasons for the continuing high percentage of uncontrolled and partially controlled course bronchial asthma in children. The purpose of this work is to identify changes in cytokine status indicators and immunograms – markers of the risk of uncontrolled bronchial asthma. 167 patients with bronchial asthma were examined, who, based on a standard clinical and instrumental examination, according to the criteria of clinical recommendations, were divided into two groups – controlled (70 people) and partially controlled and uncontrolled (97 children). All of them had their cytokines and IgA, IgM, IgG, IgE levels determined, in blood serum by ELISA, subpopulations of lymphocytes by flow cytometry, indicators of neutrophilic phagocytosis by light microscopy. In the group with uncontrolled asthma, the following significant differences were noted: a decrease in the level of IL-7, IL-9 and an increase in IL-8, there is also a higher level of B lymphocytes, IgE and IgM, and a lower level of IgA, similar changes, but less pronounced, were previously detected in other studies when comparing patients with bronchial asthma and conditionally healthy, as well as mild and severe course diseases. There were no significant differences in the other studied indicators. It is noteworthy that the greater influence on the control of the disease in bronchial asthma is not exerted by atopic cytokines responsible for the very fact of atopic inflammation, but by cytokines of general inflammation, such as IL-7, IL-8, IL-9, regulating the severity of inflammation in general, the role of IL-8 as a cytokine of granulocyte chemotaxis regulating local inflammation is especially interesting.

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The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

Abstract: To study the functional state of neutrophils in patients with bronchial asthma, bronchial asthma + COPD, COPD and community-acquired pneumonia to expand diagnosis, to determine the individual characteristics of the patients of the studied groups and choose the optimal methods of treatment.

Cited by 2 publications

References 51 publications

Seasonality in testing and positive respiratory bacterial infections in the Australian Capital Territory, 1997–2007

Seasonality in testing and positive respiratory bacterial infections in the Australian Capital Territory, 1997–2007

Indicators of the cytokine profile and standard immunogram in the controlled and uncontrolled course of bronchial asthma in children

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