“…Defects in the craniofacial region in particular are difficult to treat because of the emphasis on positive aesthetic outcomes and the number of tissue types (bone, cartilage, muscle, and skin) and structures (auricle, orbit, nose, oral cavity) in close proximity. The current options for reconstructive surgery to treat these defects include grafts, local tissue rearrangement which fills defects with adjacent healthy tissue, microsurgical tissue transfer whereby one area of the body is transferred with its blood supply to another area 10,22 , and vascularized composite allotransplantation whereby a portion of the body containing skin, muscle and/or bone is transplanted from one patient to another 16 . However, the major challenges with using traditional reconstructive surgery to treat large craniofacial defects are donor-site morbidity and procuring sufficient donor tissue with the same properties, including skin color, quantity and contour of bone, and quantity and quality of subcutaneous tissues, as the surrounding recipient tissue to restore normal anatomic structure and primary organ functions.…”