The future of ambulatory surgery for geriatric patients

Vann, Mary Ann

doi:10.1016/j.bpa.2022.12.004

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The demand for bone regeneration is increasing in the medical field owing to the aging global population ( Martyniak et al, 2021 ; Vann, 2023 ). Although autogenous bone grafting is currently the gold standard treatment for bone regeneration, it is limited by supply constraints, high morbidity rates, donor-site pain, and potential graft resorption ( Betz, 2002 ; Oryan et al, 2014 ; de Azambuja Carvalho et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction

Wang,

Shimabukuro,

Kishida

et al. 2024

Front. Bioeng. Biotechnol.

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Both the composition and architecture of artificial bone govern bone regeneration. Herein, carbonate apatite (CAp), which has a similar mineral composition to bone, was prepared by immersing calcium carbonate (CaCO3) in a phosphate solution with varying acidification levels (pH 6.0) to pH 8.9, to reveal the influence of pH on the composition and architecture of the resultant CAp granules. The composition, crystal morphology, and architecture of resultant CAp granules was well-characterized by X-ray diffraction, scanning electron microscopy, mercury intrusion porosimetry and so on. Consequently, the rate of compositional transformation from CaCO3 to CAp was much higher at pH 6.0 and pH 7.0 than pH 8.0 and pH 8.9. The pH of the phosphate solution did not affect the macroarchitecture of the resultant CAp granules. In contrast, the composition, crystal morphology, microarchitecture, and degradation behavior of the resultant CAp granules were affected by pH of the phosphate solution. In particular, the open-pore distributions and volumes of the CAp granules prepared at pH 6.0–8.9 were changed to reflect the microarchitecture of the samples. Therefore, this study revealed that the pH-controlled elution precipitation reaction is useful for controlling the composition, crystal morphology, microarchitecture, and degradation behavior of the resultant CAp, while preserving its macroarchitecture. Our findings provide fundamental insights into the design of artificial bones for bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction

Wang,

Shimabukuro,

Kishida

et al. 2024

Front. Bioeng. Biotechnol.

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“…The aging population has rapidly driven the demand for bone regeneration. 1 Although the gold standard for bone regeneration is autogenous bone grafting, the number of autogenous bone grafts that can be harvested remains small, and the harvest site is damaged. 2 Allografts and xenografts are used in clinical practice; however, they are associated with rejection and infection.…”

Section: Introductionmentioning

confidence: 99%

Superiority of Triply Periodic Minimal Surface Gyroid Structure to Strut-Based Grid Structure in Both Strength and Bone Regeneration

Hayashi

Kishida

Tsuchiya

et al. 2023

ACS Appl. Mater. Interfaces

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The aging population has rapidly driven the demand for bone regeneration. The pore structure of a scaffold is a critical factor that affects its mechanical strength and bone regeneration. Triply periodic minimal surface gyroid structures similar to the trabecular bone structure are considered superior to strut-based lattice structures (e.g., grids) in terms of bone regeneration. However, at this stage, this is only a hypothesis and is not supported by evidence. In this study, we experimentally validated this hypothesis by comparing gyroid and grid scaffolds composed of carbonate apatite. The gyroid scaffolds possessed compressive strength approximately 1.6-fold higher than that of the grid scaffolds because the gyroid structure prevented stress concentration, whereas the grid structure could not. The porosity of gyroid scaffolds was higher than that of the grid scaffolds; however, porosity and compressive strength generally have a trade-off relationship. Moreover, the gyroid scaffolds formed more than twice the amount of bone as grid scaffolds in a critical-sized bone defect in rabbit femur condyles. This favorable bone regeneration using gyroid scaffolds was attributed to the high permeability (i.e., larger volume of macropores or porosity) and curvature profile of the gyroid structure. Thus, this study validated the conventional hypothesis using in vivo experiments and revealed factors that led to this hypothetical outcome. The findings of this study are expected to contribute to the development of scaffolds that can achieve early bone regeneration without sacrificing the mechanical strength.

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Transformable Carbonate Apatite Chains as a Novel Type of Bone Graft

Hayashi,

Kishida,

Tsuchiya

et al. 2024

Adv Healthcare Materials

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The aging global population is generating an ever‐increasing demand for bone regeneration. Various materials, including blocks, granules, and sponges, have been developed for bone regeneration. However, blocks require troublesome shaping and exhibit poor bone‐defect conformities; granules migrate into the surrounding tissues during and after filling of the defect, causing handling difficulties and complications; and sponges contain polymers that are subject to religious restrictions, lack osteoconductivity, and may cause inflammation and allergies. Herein, we present carbonate apatite chains that overcome the limitations of the conventional materials. Although carbonate apatite granules migrate, causing inflammation and ectopic calcification, the chains remain in the defects without causing any complications. The chains conform to the defect shape and transform into 3D porous structures, resulting in faster bone regeneration than that observed using granules. Thus, our findings indicate that even traditional calcium phosphates materials can be converted to state‐of‐the‐art materials via shape control.This article is protected by copyright. All rights reserved

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The future of ambulatory surgery for geriatric patients

Cited by 3 publications

References 31 publications

Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction

Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction

Superiority of Triply Periodic Minimal Surface Gyroid Structure to Strut-Based Grid Structure in Both Strength and Bone Regeneration

Transformable Carbonate Apatite Chains as a Novel Type of Bone Graft

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