The application of a full vehicle model with MBS (>100 DOF) in real time has now become reality. This makes it possible to efficiently evaluate vehicle handling performance in the whole vehicle. An array of chassis design parameters (e.g. geometries, kinematics, hard points) can be evaluated in combination with systems (e.g. air suspensions, steering, powertrain). New applications are possible, such as the MIL, SIL and HIL tool chain, to validate the interactions with controllers and their variants. Tools and methods (e.g. automation, analysis) can be added. Best combinations can be achieved by using DoE methodstransferred from powertrain ECU calibration.