The future of laboratory medicine — A 2014 perspective

Kricka, Larry J.; Polsky, Tracey G.; Park, Jason; Fortina, Paolo

doi:10.1016/j.cca.2014.09.005

Cited by 27 publications

(14 citation statements)

References 112 publications

(126 reference statements)

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“…Plotting the future course of laboratory medicine is difficult, and history has shown that attempts to predict future developments are often unsuccessful (17). This article presents selected developments that have the potential to change the way in which laboratory medicine is practiced in central laboratories or at the point of care.…”

Section: Discussionmentioning

confidence: 99%

Data Mining and Predictive Behavior

2015

A Futurist's Guide to Emergency Management

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Several emerging or disruptive technologies can be identified that might, at some point in the future, displace established laboratory medicine technologies and practices. These include increased automation in the form of robots, 3-D printing, technology convergence (e.g., plug-in glucose meters for smart phones), new point-of-care technologies (e.g., contact lenses with sensors, digital and wireless enabled pregnancy tests) and testing locations (e.g., Retail Health Clinics, new at-home testing formats), new types of specimens (e.g., cell free DNA), big biology/ data (e.g., million genome projects), and new regulations (e.g., for laboratory developed tests).In addition, there are many emerging technologies (e.g., planar arrays, mass spectrometry) that might find even broader application in the future and therefore also disrupt current practice. One interesting source of disruptive technology may prove to be the Qualcomm Tricorder XPrize, currently in its final stages.

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Section: Discussionmentioning

confidence: 99%

Data Mining and Predictive Behavior

2015

A Futurist's Guide to Emergency Management

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“…The advent of advanced information technologies, automation, and measurement technologies provides unique opportunities for the synergies and the consolidation among different specialized laboratories [21]. However, these synergies are seldom utilized to their full extents except by large laboratory corporations.…”

Section: Discussionmentioning

confidence: 99%

“…The implementation of personalized medicine will imply a steep increase in the number of performed screening or diagnostic tests and a larger volume of data to be gathered, analyzed, and translated into information to serve as guidance for clinical decisions [21][22][23]. Substantial upfront investments are furthermore needed for instrumentation, structural changes, education, and training efforts [9,[24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe

Malentacchi

Mancini

Brandslund

et al. 2015

Drug Metabolism and Personalized Therapy

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Developments in "-omics" are creating a paradigm shift in laboratory medicine leading to personalized medicine. This allows the increase in diagnostics and therapeutics focused on individuals rather than populations. In order to investigate whether laboratory medicine is ready to play a key role in the integration of personalized medicine in routine health care and set the state-of-the-art knowledge about personalized medicine and laboratory medicine in Europe, a questionnaire was constructed under the auspices of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and the European Society of Pharmacogenomics and Personalised Therapy (ESPT). The answers of the participating laboratory medicine professionals indicate that they are aware that personalized medicine can represent a new and promising health model, and that laboratory medicine should play a key role in supporting the implementation of personalized medicine in the clinical setting. Participants think that the current organization of laboratory medicine needs additional/relevant implementations such as (i) new technological facilities in -omics; (ii) additional training for the current personnel focused on the new methodologies; (iii) incorporation in the laboratory of new competencies in data interpretation and counseling; and (iv) cooperation and collaboration among professionals of different disciplines to integrate information according to a personalized medicine approach.Brought to you by | MIT Libraries Authenticated Download Date | 5/10/18 11:36 PM 122 Malentacchi et al.: Is laboratory medicine ready for the era of personalized medicine?

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“…64 Furthermore, the sequencing of the genomes of all of the cancers in the United States is now theoretically feasible. 65 However, a recognized bottleneck to developing precision medicine in oncology is the availability of effective therapeutics. Without useful therapeutics, the utility of sequencing a vast number of tumors of patients remains in the realm of research.…”

Section: Novel Clinical Trial Designs For Precisionmentioning

confidence: 99%

Precision Medicine in Gastrointestinal Pathology

Wang

Park

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Precision medicine is the promise of individualized therapy and management of patients based on their personal biology. There are now multiple global initiatives to perform whole-genome sequencing on millions of individuals. In the United States, an early program was the Million Veteran Program, and a more recent proposal in 2015 by the president of the United States is the Precision Medicine Initiative. To implement precision medicine in routine oncology care, genetic variants present in tumors need to be matched with effective clinical therapeutics. When we focus on the current state of precision medicine for gastrointestinal malignancies, it becomes apparent that there is a mixed history of success and failure.Objective.-To present the current state of precision medicine using gastrointestinal oncology as a model. We will present currently available targeted therapeutics, promising new findings in clinical genomic oncology, remaining quality issues in genomic testing, and emerging oncology clinical trial designs. Data Sources.-Review of the literature including clinical genomic studies on gastrointestinal malignancies, clinical oncology trials on therapeutics targeted to molecular alterations, and emerging clinical oncology study designs.Conclusions.-Translating our ability to sequence thousands of genes into meaningful improvements in patient survival will be the challenge for the next decade.

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The future of laboratory medicine — A 2014 perspective

Cited by 27 publications

References 112 publications

Data Mining and Predictive Behavior

Data Mining and Predictive Behavior

Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe

Precision Medicine in Gastrointestinal Pathology

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