The Future of Neurology

Biller, José; Schneck, Michael

doi:10.3389/fneur.2011.00001

Cited by 40 publications

(55 citation statements)

References 6 publications

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“…The waveform is qualitatively similar to the idealized pressure vs time signature from Kinney & Graham (Kinney, 1985). The deviations seen from blast wave characteristics predicted by the Friedlander waveform (Kinney, 1985, Bass et al, 2008, Varas, 2011) at higher overpressures can be attributed to the effects of blast wave reflection, diaphragm rupture, interactions between the expanding air and the arrow inside the driven section and minor variations in the internal diameter of the union and the expansion section.…”

Section: Discussionmentioning

confidence: 86%

“…Varas et al 2011 presented results from the Bass lethality model (Bass et al, 2008) showing that the average IED blast has an overpressure between 10 and 200 kPa (1.45 and 29.00 psi), and a positive phase duration of 4 to 10 ms. A driver pressure of 65 psi in our shock tube produced a blast wave with a peak overpressure of 14.28 psig and a positive phase duration of 6–7 ms, which replicates the loading conditions produced by an average IED blast with respect to these two parameters only. Overpressure and positive phase duration are considered to be the major contributors to significant anatomical and physiological effects of blast waves (Varas, 2011).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low-cost blast wave generator for studies of hearing loss and brain injury: Blast wave effects in closed spaces

Newman

Hayes

Rao

et al. 2015

Journal of Neuroscience Methods

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Background Military personnel and civilians living in areas of armed conflict have increased risk of exposure to blast overpressures that can cause significant hearing loss and/or brain injury. The equipment used to simulate comparable blast overpressures in animal models within laboratory settings is typically very large and prohibitively expensive. New Method To overcome the fiscal and space limitations introduced by previously reported blast wave generators, we developed a compact, low-cost blast wave generator to investigate the effects of blast exposures on the auditory system and brain. Results The blast wave generator was constructed largely from off the shelf components, and reliably produced blasts with peak sound pressures of up to 198 dB SPL (159.3 kPa) that were qualitatively similar to those produced from muzzle blasts or explosions. Exposure of adult rats to 3 blasts of 188 dB peak SPL (50.4 kPa) resulted in significant loss of cochlear hair cells, reduced outer hair cell function and a decrease in neurogenesis in the hippocampus. Comparison to existing methods Existing blast wave generators are typically large, expensive, and are not commercially available. The blast wave generator reported here provides a low-cost method of generating blast waves in a typical laboratory setting. Conclusions This compact blast wave generator provides scientists with a low cost device for investigating the biological mechanisms involved in blast wave injury to the rodent cochlea and brain that may model many of the damaging effects sustained by military personnel and civilians exposed to intense blasts.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Low-cost blast wave generator for studies of hearing loss and brain injury: Blast wave effects in closed spaces

Newman

Hayes

Rao

et al. 2015

Journal of Neuroscience Methods

View full text Add to dashboard Cite

show abstract

“…The latter is viewed central in career decisions for the current generation of neurologists. 7 Bradley 8 proposed a rise in the number of medical graduates entering neurology residency between 2000 and 2020. The estimation was supported by the explosion of knowledge in neuroscience and potential insights into previously unclear disorders.…”

Section: Methodsmentioning

confidence: 99%

International Issues: An international survey of young neurologists' perceptions of future health care and neurology

et al. 2015

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International Issues: An international survey of young neurologists' perceptions of future health care and neurologyThe future occupations and interests of the medical profession have to be in some respects different from those of the past, and they have to be more various. 1Medicine continues to evolve in response to our greater understanding of disorders and the discovery of new therapies. As the 21st century begins, once again neurology finds itself in a pivotal evolutionary point of its eventful history. Breakthrough discoveries linked to molecular biology and genetic engineering have made personalized medicine foreseeable. 2Information technologies have paved the way for consultation of remote patients and have adapted to the educational demands of upcoming neurologists, patients, and caregivers. Moreover, there has been an increase in the percentage of women in the neurology workforce.3 Importantly, the voice of junior neurologists is increasingly recognized and incorporated in decision-making processes at the national and continental level. 4 The spectrum of neurology has been ever changing and frontiers have to be regularly redefined. In some countries, subspecialties have been established to deal with different needs required by acute and chronic neurologic diseases.5 Demand and allocation of specialized doctors is likely to be defined by 3 interconnected developments: the aging population, the parallel rise in chronic disease, and the affordability of health care. Indeed, contemporary health care is barely managing to cover its costs and gaps in sufficient neurology service have become evident across Europe. 6 There are limited data available on the current visions of neurologists for health care and neurology. It would be interesting to know whether the upcoming generation of neurologists is aware of global health care concerns. We aimed to garner ideas about current challenges and future development of health care among residents and junior neurologists from member states of the European Union and neighboring countries. We further assessed emerging constraints for clinical practice as well as perceptions for the development of neurology subdisciplines and core competences.METHODS Details on the Methods are in appendix e-1 on the Neurology ® Web site at Neurology.org. The questionnaire is provided in appendix e-2.RESULTS Demographics. A total of 86 participants completed the survey, yielding a participation rate of 80%. There were 45 in residency training (median 4.6 years [interquartile range (IQR) 1-12] since graduation from medical school) and 41 board-certified neurologists (for a median of 5.5 years ).

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“…A standard pretreatment MRI protocol was used for all patients. The T1-weighted, gadolinium-enhanced MRI was used to measure tumor size on the axial plane and to determine tumor volume using the CyberKnife planning software [20]. All follow-up images were obtained using the same scanner and scanning parameters.…”

Section: Methodsmentioning

confidence: 99%

A Proposed Method to Comprehensively Define Outcomes in Acoustic Tumor Patients Undergoing CyberKnife Management

Lin¹,

Chen

Tseng

et al. 2013

Stereotact Funct Neurosurg

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Background: Vestibular assessment in patients with acoustic tumor (so-called vestibular schwannoma, VS) via ocular vestibular-evoked myogenic potential (oVEMP) and cervical VEMP (cVEMP) tests are not often discussed in the neurosurgical literature. Objectives: This study conducted physiological and morphological assessments for VS patients before and after CyberKnife radiosurgery. Methods: Twenty patients with unilateral VS underwent a battery of tests comprising facial nerve function test, audiometry, and caloric, oVEMP and cVEMP tests before and 2 years after CyberKnife treatment at a mean dosage of 18 Gy in 3 fractions. Results: The abnormal percentages of caloric, oVEMP and cVEMP tests did not significantly differ before and after Cyberknife treatment, indicating that preservation of the superior and inferior vestibular nerves can be achieved after radiosurgery. Median tumor volumes, 1.49 cm³ before treatment versus 0.97 cm³ at 2 years after treatment, differed significantly. Conclusions: The use of oVEMP and cVEMP tests in VS patients before stereotactic radiosurgery may help to evaluate the tumor origin from the superior or inferior vestibular nerve. It takes a short time and costs less, and it would be practical to make this a routine examination in VS patients having stereotactic radiosurgery.

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The Future of Neurology

Cited by 40 publications

References 6 publications

Low-cost blast wave generator for studies of hearing loss and brain injury: Blast wave effects in closed spaces

Low-cost blast wave generator for studies of hearing loss and brain injury: Blast wave effects in closed spaces

International Issues: An international survey of young neurologists' perceptions of future health care and neurology

A Proposed Method to Comprehensively Define Outcomes in Acoustic Tumor Patients Undergoing CyberKnife Management

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