The Future of Preventing and Treating Nipah Virus Infection

Satterfield, Benjamin A.

doi:10.4155/fsoa-2017-0056

Cited by 7 publications

(10 citation statements)

References 19 publications

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“…A collaborative effort has been undertaken by both government and pharmaceutical companies, known as the Coalition for Epidemic Preparedness Innovations (CEPI). It was formed in January 2017 for developing safe, efficacious and affordable vaccines against diseases associated with pandemic potential, like Nipah (Satterfield 2017). NiV, Lassa virus and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have been afforded high priority by CEPI.…”

Section: Vaccinesmentioning

confidence: 99%

“…CEPI aims to develop two new experimental vaccines within five years, in the first phase of the clinical trial. It is anticipated that field efficacy studies of such vaccines could be done during massive outbreaks (Satterfield 2017). CEPI has recently signeda $25 million contract with two US Biotech companies, i.e.…”

Section: Vaccinesmentioning

confidence: 99%

“…2017). With climate change and human encroachment into flying fox habitats, it is likely that outbreaks will occur in new locations (Satterfield 2017). Strategies other than vaccination also play crucial roles in prevention and control of human NiV infection and would prove to be more economical.…”

Section: Prevention and Control Measuresmentioning

confidence: 99%

“…It involves keeping fruit as well as bat roosting trees away from the livestock farms and grazing lands susceptible to virus contamination. In certain countries, like Malaysia, such effort is already proven to be highly effective (Satterfield 2017). The control is much tougher in regions where contaminated date palm sap is the primary source of NiV.…”

Section: Prevention and Control Measuresmentioning

confidence: 99%

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Nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies – a comprehensive review

Singh

Dhama

Chakraborty³

et al. 2019

Veterinary Quarterly

191

125

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Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservoir host. The disease was reported for the first time from the Kampung Sungai Nipah village of Malaysia in 1998. Human-to-human transmission also occurs. Outbreaks have been reported also from other countries in South and Southeast Asia. Phylogenetic analysis affirmed the circulation of two major clades of NiV as based on currently available complete N and G gene sequences. NiV isolates from Malaysia and Cambodia clustered together in NiV-MY clade, whereas isolates from Bangladesh and India clusterered within NiV-BD clade. NiV isolates from Thailand harboured mixed population of sequences. In humans, the virus is responsible for causing rapidly progressing severe illness which might be characterized by severe respiratory illness and/or deadly encephalitis. In pigs below six months of age, respiratory illness along with nervous symptoms may develop. Different types of enzyme-linked immunosorbent assays along with molecular methods based on polymerase chain reaction have been developed for diagnostic purposes. Due to the expensive nature of the antibody drugs, identification of broad-spectrum antivirals is essential along with focusing on small interfering RNAs (siRNAs). High pathogenicity of NiV in humans, and lack of vaccines or therapeutics to counter this disease have attracted attention of researchers worldwide for developing effective NiV vaccine and treatment regimens.

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Section: Vaccinesmentioning

confidence: 99%

Section: Vaccinesmentioning

confidence: 99%

Section: Prevention and Control Measuresmentioning

confidence: 99%

Section: Prevention and Control Measuresmentioning

confidence: 99%

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Nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies – a comprehensive review

Singh

Dhama

Chakraborty³

et al. 2019

Veterinary Quarterly

191

125

View full text Add to dashboard Cite

show abstract

“…Our most-read article for 2018 is an Editorial from Benjamin Satterfield (Mayo Clinic, MN, USA), discussing Nipah virus, a concerning paramyxovirus that is fairly well understood, but for which methods for prevention and cure are lacking [6]. With nearly 3000 downloads, our readers clearly agree that more effort needs to be expended in this field.…”

Section: Content Highlightsmentioning

confidence: 99%