INTRODUCTION: Neighborhood deprivation has been associated with chronic diseases and with gut microbial alterations.Although cirrhosis is associated with gut microbiome changes and hepatic encephalopathy (HE), their association is unclear.
METHODS:Demographics and cirrhosis details (model for end-stage liver disease [MELD], prior HE, and medications) were recorded from outpatients with cirrhosis. Area deprivation index (ADI), which ranks neighborhoods by socioeconomic disadvantage, was recorded as state decile and national percentile (high 5 worse for both) and dichotomized on the median. Patients underwent cognitive testing to diagnose minimal HE (MHE). Stool microbiota was analyzed using 16S ribosomal RNA for a/b-diversity. Multivariable analysis was used to evaluate the factors independently associated with MHE.