AimThe aim of this discussion paper is twofold: (1) To critically examine the challenges related to resuscitations among rural nurses and how these contribute to a sense of professional isolation and (2) To discuss practical solutions and strategies that could be implemented to mitigate the effects of professional isolation.BackgroundProfessional isolation is not unique to rural nursing practice. It is a complex issue often observed in low‐resourced environments that are geographically distant from larger hospitals, such as small rural emergency departments. With a greater research focus placed on the recruitment and retention challenges associated with professional isolation, studies often overlook the intermediary factors contributing to this issue, such as the effect of resuscitations on rural nurses. In addition, there are few studies that have evaluated interventions or strategies to address professional isolation.DesignA critical discussion paper.MethodsThis discussion paper is based on data drawn from current evidence and is guided by the authors research experience as part of a doctoral study.ResultsProfessional isolation negatively affects rural nurses' experiences of resuscitation by creating barriers to skill acquisition and professional growth and reducing career intent in rural areas. Strategies such as leadership training, rural mentorship, debriefing and cognitive aids are possible strategies that could address these challenges.ConclusionsThe trajectory of professional isolation is contingent upon the capacity of rural nurses to have access to professional avenues that enhance connection, sharing of knowledge, skills and experiences. Addressing professional isolation is crucial for the well‐being of rural nurses and the overall sustainability and growth of the rural healthcare workforce.