The G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population

Abstract

Chronic inflammation and remodelling of the small airways are features related to chronic obstructive pulmonary disease (COPD). In the current study, we aimed to explore the possible role of MMP12 -82 A > G (rs2276109) promoter polymorphism in the development of COPD in a population from Bulgaria (167 patients with COPD and 119 control individuals). The genotype and allele distributions differed significantly between COPD patients and controls (p = .010 and p = .043, respectively, χ test). The genotypes containing at least one variant G allele (AA + GG) were more frequent in the control group than in patients (36.1% vs. 22.2%) determining 2.96-fold lower risk for COPD after adjustment for age, sex and smoking habits (OR = 0.338, 95%CI: 0.168-0.682, p = .002). Our results suggest that carriers of genotypes with at least one copy of minor G allele of rs2276109 might have lower risk for COPD development, with no marked effect on the lung function and severity of the disease.

MMP‐3 (–1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)‐3 and correlate with severity of COPD: A study of MMP‐3, MMP‐7 and MMP‐12 in a Tunisian population

“…Our findings agree with previous studies reporting a lack of correlation between the MMP‐12 (–82) A/G polymorphism and the risk of COPD among Mexican, Brazilian and Russian populations, although they are discordant with data from Hunninghake et al . and Tacheva et al . indicating that the (–82) G allele associates with a reduced risk of COPD.…”

“…and Tacheva et al30 indicating that the (-82) G allele associates with a reduced risk of COPD. The results of the present study also disagree with those of Korytina et al31 who found a significant association between the (-82) A/G variant and increased risk of chronic bronchitis.…”

Role of Genetic Susceptibility in Nicotine Addiction and Chronic Obstructive Pulmonary Disease

“…This allele is further associated with a reduced risk of COPD in adult smokers 137 . Although only one tendency was identified in Polish populations 130 , in Bulgaria, patients carrying genotypes with at least one copy of allele G could have a lower risk of COPD 138 .…”

Peer Review #1 of "The leukocyte telomere length, single nucleotide polymorphisms near TERC gene and risk of COPD (v0.1)"

“…All together 194 patients with COPD and 281 non-affected control individuals from the region of Stara Zagora, Bulgaria, were included in our case-control study. The including criteria for the individuals with COPD was as described previously (Tacheva et al 2017). The patients were recruited in the Clinic of Internal Medicine, University Hospital, Trakia University, Stara Zagora, Bulgaria from 2008 till 2011.…”