The G allele of the ADAM33 T1 polymorphism (rs2280091) is a risk factor associated with asthma severity among the Iraqi Arab population

Zayed, Karrar S.; Kudhair, Bassam K.; Aziz, Dhifaf Z.; Lafta, Inam J.

doi:10.1016/j.humgen.2023.201181

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“…The first mentioned refers to the significance of T1 polymorphic in the Arab population. The second publication also refers to their connection to aeroallergen-induced asthma for the population of West Bengal, India [39,40].…”

Section: Snpsmentioning

confidence: 99%

ADAM33′s Role in Asthma Pathogenesis: An Overview

Sleziak,

Gawor,

Błażejewska

et al. 2024

IJMS

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Asthma is a complex chronic respiratory disease characterized by airway hyperresponsiveness, inflammation, and obstruction. Many genes have been identified as associated with asthma but none with such substantial significance as the ADAM33 gene due to its role in airway remodeling and bronchial hyperresponsiveness. This review summarizes the current knowledge on the genetic and functional aspects of ADAM33 in asthma pathogenesis. We highlight its genetic variants associated with asthma susceptibility and severity, as well as the functional effects of ADAM33 on airway remodeling, smooth muscle cell proliferation, and its interplay with environmental factors. Additionally, we discuss the potential clinical implications of ADAM33 as a therapeutic target for asthma management.

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Section: Snpsmentioning

confidence: 99%