“…The Ga 12/13 subfamily has been implicated in a number of cellular functions, including Rho-dependent cytoskeletal shape changes, activation of c-Jun Nterminal kinase, and stimulation of Na + /H + exchange (Dhanasekaran and Dermott, 1996;Lin et al, 1996;Collins et al, 1997;Voyno-Yasenetskaya et al, 1996;Gohla et al, 1999). In addition, there is substantial evidence that Ga 12/13 proteins mediate signaling pathways involved in cell growth and tumorigenesis (Chan et al, 1993;Jiang et al, 1993;Jones and Gutkind, 1998;Dermott et al, 1999).…”