1991
DOI: 10.1007/bf01673258
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The GABAergic cerebello-olivary projection in the rat

Abstract: Immunocytochemical detection of glutamate decarboxylase (GAD), the predominant biosynthetic enzyme of gamma-aminobutyric acid (GABA), reveals the presence of a dense GABAergic innervation in all parts of the inferior olive. One brain center that provides a substantial projection to the inferior olive is the cerebellar nuclei, which contain many small GABAergic neurons. These neurons were tested as a source of GABAergic olivary afferents by combining retrograde tract tracing with GAD immunocytochemistry. As exp… Show more

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Cited by 209 publications
(141 citation statements)
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References 67 publications
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“…Our results provide clear evidence that the anatomical organization of the olivo-cerebellar circuit (17)(18)(19), which comprises the cerebellar cortex, the DCN, and the IO, indeed operates as a closed loop. This suggestion is in agreement with recent results of Marshal and Lang (32), demonstrating that experimentally increasing PN firing increases the firing rate and synchrony level of CS.…”
Section: Resultsmentioning
confidence: 59%
See 1 more Smart Citation
“…Our results provide clear evidence that the anatomical organization of the olivo-cerebellar circuit (17)(18)(19), which comprises the cerebellar cortex, the DCN, and the IO, indeed operates as a closed loop. This suggestion is in agreement with recent results of Marshal and Lang (32), demonstrating that experimentally increasing PN firing increases the firing rate and synchrony level of CS.…”
Section: Resultsmentioning
confidence: 59%
“…This circuit is a loop of interconnected structures where the cerebellar cortex innervates the inferior olivary nucleus (IO) via the DCN, and the olivary neurons via the climbing fibers are fed back into the cerebellar cortex. Whereas the olivary neurons exert an excitatory action on the PN at the cerebellar cortex, both the PN and DCN terminals exert an inhibitory action on their target cells (17)(18)(19). Thus, it is likely that this long-range feedback loop will be affected by the alteration in PN's activity observed in the BK −/− mouse.…”
mentioning
confidence: 99%
“…Small neurons (5-10 m in soma diameter) also were released by the cell isolation procedure. These neurons are likely to be the inhibitory neurons that project to the inferior olive (Nelson and Mugnaini, 1989;Fredette and Mugnaini, 1991;Ruigrok, 1997). As described in Materials and Methods, the present experiments were limited to the large cerebellar nuclear neurons, which had similar electrophysiological properties.…”
Section: Resultsmentioning
confidence: 99%
“…The large cells (15-25 m in soma diameter) are likely to be the glutamatergic neurons that project to the red nucleus and ventral thalamus (Bentvoglio and Kuypers, 1982;Gonzalo-Ruiz et al, 1988;Teune et al, 1995Teune et al, , 1998Shinoda et al, 1997). The small cells (5-10 m in soma diameter) are likely to be inhibitory neurons that project to the inferior olive (Nelson and Mugnaini, 1989;Fredette and Mugnaini, 1991;Ruigrok, 1997). All cerebellar nuclear recordings were made from large neurons.…”
Section: Preparation Of Isolated Neuronsmentioning
confidence: 99%
“…More recently the acoustic system recurred in the paper with Enrique Saldaña on the striking tonotopic organization of the inferior colliculus [35]. GAD histochemistry identified GABAergic neurons in structures as diverse as the amygdala and olfactory bulb [1] and it allowed him to study the cerebellar nucleo-olivary pathway as a GABAergic system [36]. The cholinergic innervation and receptors of the cerebellum were studied with Dick Jaarsma [37], while the UBC appeared as a neglected interneuron in a paper with Alessandra Floris in 1994 [23], but developed in the best-known cerebellar interneuron in a large series of Enrico's papers.…”
mentioning
confidence: 99%