The gasdermin family: emerging therapeutic targets in diseases
Chenglong Zhu,
Sheng Xu,
Ruoyu Jiang
et al.
Abstract:The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key player in pyroptosis. This recently characterized class of pore-forming effector proteins is pivotal in orchestrating processes such as membrane permeabilization, pyroptosis, and the follow-up inflammatory response, which are crucial self-defense mechanisms against irritants and infections. GSDMs have been implicated in a range of diseases including, but not limited to, sepsis, viral infections,… Show more
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