The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium

Xu, Jiawen; Gao, Dong-Dong; Peng, Lei; Qiu, Zhen; Ke, Li-Jiao; Zhu, Yun-Xin; Zhang, Yilin; Zhou, Wen‐Liang

doi:10.1016/j.niox.2019.05.011

Cited by 7 publications

(4 citation statements)

References 76 publications

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“…Cystic fibrosis transmembrane conductance regulator (CFTR) facilitates the release of Clto promote the secretion of uterine fluid; however, its overexpression can lead to the formation of hydrops and hence prevent embryo implantation [148]. Xu et al [107] showed that exogenous administration of H 2 S increased the concentration of Clin mouse endometrial epithelial cells and the I --dependent short-circuit current (ISC). A specific CFTR inhibitor, CFTRinh-172, attenuated the increase in ISC following pretreatment.…”

Section: H 2 S Promotes Embryo Implantationmentioning

confidence: 99%

Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Sun,

Mao,

Xie

et al. 2024

Biomolecules

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Hydrogen sulfide (H2S), previously regarded as a toxic exhaust and atmospheric pollutant, has emerged as the third gaseous signaling molecule following nitric oxide (NO) and carbon monoxide (CO). Recent research has revealed significant biological effects of H2S in a variety of systems, such as the nervous, cardiovascular, and digestive systems. Additionally, H2S has been found to impact reproductive system function and may have therapeutic implications for reproductive disorders. This paper explores the relationship between H2S and male reproductive disorders, specifically erectile dysfunction, prostate cancer, male infertility, and testicular damage. Additionally, it examines the impact of H2S regulation on the pathophysiology of the female reproductive system, including improvements in preterm birth, endometriosis, pre-eclampsia, fetal growth restriction, unexplained recurrent spontaneous abortion, placental oxidative damage, embryo implantation, recovery of myometrium post-delivery, and ovulation. The study delves into the regulatory functions of H2S within the reproductive systems of both genders, including its impact on the NO/cGMP pathway, the activation of K+ channels, and the relaxation mechanism of the spongy smooth muscle through the ROCK pathway, aiming to broaden the scope of potential therapeutic strategies for treating reproductive system disorders in clinical settings.

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Section: H 2 S Promotes Embryo Implantationmentioning

confidence: 99%

Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Sun,

Mao,

Xie

et al. 2024

Biomolecules

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show abstract

“…H 2 S signaling is also essential for maintaining early pregnancy, and its deficiency can lead to reduced litter size due to early embryo loss or placental inflammation ( 70 , 124 ). H2S may further facilitate the physiological implantation of the embryo by regulating ion transport activity in the endometrial epithelium and supporting DNA synthesis ( 125–127 ).…”

Section: Detection Of H 2 S-producing Enzymes and ...mentioning

confidence: 99%

Hydrogen sulfide and its role in female reproduction

Pilsova,

Klusackova

et al. 2024

Front. Vet. Sci.

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Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). H2S is crucial in various physiological processes associated with female mammalian reproduction. These include estrus cycle, oocyte maturation, oocyte aging, ovulation, embryo transport and early embryo development, the development of the placenta and fetal membranes, pregnancy, and the initiation of labor. Despite the confirmed presence of H2S-producing enzymes in all female reproductive tissues, as described in this review, the exact mechanisms of H2S action in these tissues remain in most cases unclear. Therefore, this review aims to summarize the knowledge about the presence and effects of H2S in these tissues and outline possible signaling pathways that mediate these effects. Understanding these pathways may lead to the development of new therapeutic strategies in the field of women’s health and perinatal medicine.

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“…7 H 2 S has also been reported to have an inhibitory effect on pathological calcification, 8 activation of hepatic stellate cells, thus increasing the cellular bioenergetics and HSC proliferation, 9 and even in the implantation of the embryo into the murine endometrium. 10 The physiological influence of H 2 S is thus spread over a wide range of biological processes, thus making it an important gasotransmitter to investigate. The gasotransmitter action of H 2 S has also prompted the study of H 2 S prodrugs that can release H 2 S into the system upon administration 11 that could assist in managing pathophysio-logical conditions.…”

mentioning

confidence: 99%

“…Such a difference in endogenously produced vs exogenously delivered H 2 S can also be seen in neurodegenerative diseases . H 2 S has also been reported to have an inhibitory effect on pathological calcification, activation of hepatic stellate cells, thus increasing the cellular bioenergetics and HSC proliferation, and even in the implantation of the embryo into the murine endometrium . The physiological influence of H 2 S is thus spread over a wide range of biological processes, thus making it an important gasotransmitter to investigate.…”

mentioning

confidence: 99%

Autonomous Temporal Control of Hydrogen Sulfide Delivery

Iyer

Eddington

2019

Anal. Chem.

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Hydrogen sulfide (H2S) is dichotomous in nature as it is lethal at higher concentrations, but at lower concentrations it shows a more cytoprotective nature. Due to its involvement in many physiological processes, it has recently risen to significance as a gasotransmitter alongside carbon monoxide (CO) and nitric oxide (NO). Experimentation using H2S is thus important to generate in vitro and in vivo models for this ubiquitous gasotransmitter. However, laboratory studies involving H2S are challenging due to the special handling conditions required to work with such a toxic gas. The use of chemical donors in the cell culture also show temporally varying release profiles, which are not optimal when trying to control H2S in cell cultures lasting several days. Previously we applied microfluidics to deliver stable concentrations of H2S, and in this work, we demonstrate a novel experimental method incorporating feedback control to precisely deliver H2S that accounts for donor solution concentration decay.

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The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium

Cited by 7 publications

References 76 publications

Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Hydrogen sulfide and its role in female reproduction

Autonomous Temporal Control of Hydrogen Sulfide Delivery

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