The gastric mucosa in gastric cancer patients in a low-incidence area

Genta, Robert M.; Pusztaszeri, Marc

doi:10.1097/01.meg.0000231753.58211.05

Cited by 5 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the observed diminishing OR for the intestinal type cancer in our regression model strengthens our suggestion. Another limitation of our study is that due to retrospective nature of our gastric cancer material and unreliability of resection specimens in the diagnosis of the infection (Genta and Pusztaszeri, ), we were not able to correlate the genotype frequencies with H. pylori infection in the cancer series. However, the importance of H. pylori in the pathogenesis of gastric cancer has been well documented, and in agreement with previous observations (Sipponen and Marshall, ), signs of chronic gastritis were present in majority (58/61; 96%) of gastric cancer patients.…”

Section: Discussionmentioning

confidence: 98%

Interleukin 6 gene polymorphism ‐174 is associated with the diffuse type gastric carcinoma

Pohjanen

Koivurova

Mäkinen

et al. 2013

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

The aim of this study was to assess the significance of the interleukin 6 gene polymorphism -174 in gastric cancer risk. The interleukin 6 -174 G/C (rs1800795) gene polymorphisms was analyzed in gastric cancer, peptic ulcer, and nonulcer dyspepsia patients and in healthy control subjects and the data were correlated with the histopathological features of the patients' biopsies. The interleukin 6 -174 GG and GC genotypes have been previously associated with high interleukin 6 serum levels. We discovered that the interleukin 6 -174 GG and GC genotypes are associated with an increased risk of the diffuse histologic subtype of gastric carcinomas (OR: 6.809, P = 0.034), but absent in the intestinal type carcinomas (OR: 1.109, P = 0.908). No significant associations with peptic ulcer, gastric atrophy, or intestinal metaplasia were seen. Our results demonstrate that the interleukin 6 -174 GG and GC genotypes increase the risk of the diffuse type gastric carcinoma, but not the intestinal type gastric carcinoma or its precursor conditions, including atrophy or intestinal metaplasia. Thus, interleukin 6 seems to be an important carcinogenetic factor in the diffuse type gastric adenocarcinoma and its carcinogenetic effect could be noninflammatory.

show abstract

Section: Discussionmentioning

confidence: 98%

Interleukin 6 gene polymorphism ‐174 is associated with the diffuse type gastric carcinoma

Pohjanen

Koivurova

Mäkinen

et al. 2013

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

show abstract

“…However, if there are features suggestive of a dropout of oxyntic glands, an immunohistochemical stain for gastrin‐producing cells (G cells) will be needed to establish the origin of each fragment (G cells, abundant in the antrum, are rare or absent from the oxyntic mucosa) and to determine whether corpus atrophy is present . Pepsinogen I staining, although not widely available in non‐specialised laboratories, is also a very specific tool to identify the atrophic corpus by highlighting the native oxyntic commitment of the pseudo‐pyloric metaplastic glands . However, these stains add considerable expense to the processing of a gastric biopsy set.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Sydney System guidelines increases the detection ofHelicobactergastritis and intestinal metaplasia in 400 738 sets of gastric biopsies

Lash¹,

Genta²

2013

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Three were classified as a mixed type. Other studies have also reported that cardia cancers are predominantly of intestinal type [14, 31], whereas ECL-cell-derived cancer developing in hypergastrinemic patients with pernicious anaemia are of the diffuse type [19]. …”

Section: Discussionmentioning

confidence: 99%

Gastric Carcinomas Localized to the Cardia

Bakkelund

Nordrum²,

Fossmark

2012

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading to hypergastrinemia has increased considerably during the last decades. We have examined cardia cancers for neuroendocrine and ECL cell differentiation. Methods. Thirty-two cardia cancers were examined by immunohistochemical labelling of chromogranin A (CgA), synaptophysin, serotonin, and histidine decarboxylase (HDC). Information about PPI use was collected from the patient records. Results. In 15 of 32 tumours, there were positive signs for one or several neuroendocrine markers. Five cases were CgA and serotonin positive; three of these carcinomas were also positive for HDC. Three patients were long-term users of PPI, and two of these were immunoreactive for neuroendocrine markers. Conclusions. A high proportion of cardia cancers expressed neuroendocrine markers, but only few patients with cardia cancers were using PPI.

show abstract

The gastric mucosa in gastric cancer patients in a low-incidence area

Cited by 5 publications

References 26 publications

Interleukin 6 gene polymorphism ‐174 is associated with the diffuse type gastric carcinoma

Interleukin 6 gene polymorphism ‐174 is associated with the diffuse type gastric carcinoma

Adherence to the Sydney System guidelines increases the detection ofHelicobactergastritis and intestinal metaplasia in 400 738 sets of gastric biopsies

Gastric Carcinomas Localized to the Cardia

Contact Info

Product

Resources

About