The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population

Onuma, Hiroshi; Tabara, Yasuharu; Kawamoto, Ryuichi; Shimizu, Ikki; Kawamura, Ryuichi; Takata, Yasunori; Nishida, Wataru; Ohashi, Jun; Miki, Tetsuro; Kohara, Katsuhiko; Makino, Hideichi; Osawa, Haruhiko

doi:10.1038/jhg.2010.75

Cited by 63 publications

(45 citation statements)

References 23 publications

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“…SNPs (rs780094 and rs1260326) in the GCKR gene were previously reported to be associated with metabolic disorders; [27][28][29] however, the present study did not show the association with metabolic syndrome. The C-allele of rs780094 was reported to be associated with increased fasting plasma glucose and lower triglyceride levels.…”

Section: Discussioncontrasting

confidence: 56%

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

Hotta

Kitamoto

et al. 2011

J Hum Genet

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Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P¼0.00013), rs8050136 (P¼0.00011), rs1558902 (P¼6.6Â10 À5 ) and rs1421085 (P¼7.4Â10 À5 ). rs3764220 in the SCG3 gene (P¼0.0010) and rs2293855 in the MTMR9 gene (P¼0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNPÂSNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.

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Section: Discussioncontrasting

confidence: 56%

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

Hotta

Kitamoto

et al. 2011

J Hum Genet

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“…The majority of genetic loci for type 2 diabetes have been initially detected in populations of European descent, except for KCNQ1 [2,3], UBE2E2 [4] and C2CD4A/C2CD4B [4], which were first identified in Japanese GWAS. Among the type 2 diabetes susceptibility loci discovered in European studies, several loci, including TCF7L2, CDKAL1, HHEX, SLC30A8, KCNJ11, CDKN2A/B, IGF2BP2 and GCKR, have been confirmed as type 2 diabetes risk loci in Japanese populations [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population

et al. 2011

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Aims/hypothesis Recently, rs10906115 in CDC123/ CAMK1D, rs1359790 near SPRY2, rs1436955 in C2CD4A/ C2CD4B and rs10751301 in ODZ4 were identified as genetic risk variants for type 2 diabetes by a genome-wide association study in a Chinese population. The aim of the present study was to ascertain the role of these four variants in conferring susceptibility to type 2 diabetes in the Japanese population. Methods We genotyped 11,530 Japanese individuals (8,552 type 2 diabetes cases, 2,978 controls) for the above single nucleotide polymorphisms (SNPs) and used logistic regression analysis to determine whether they were associated with type 2 diabetes. Results In accordance with the findings in a Chinese population, rs10906115 A, rs1359790 C and rs1436955 G were found to be risk alleles. Both rs10906115 and rs1359790 were significantly associated with susceptibility to type 2 diabetes in our study (rs10906115 OR 1.15, 95% CI 1.08, 1.22; p=6.10×10 −6 ; rs1359790 OR 1.14, 95% CI

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“…In several genome-wide association studies, the derived "A" allele of rs780094 was found to be associated with several metabolic phenotypes in various ethnic groups. These phenotypes included higher triglycerides, reduced risk of T2DM, lower fasting glucose, lower fasting insulin, lower HOMA-IR, lower HOMA-β, higher 2-h glucose on the oral glucose tolerance test, higher C-reactive protein, and increased risk of non-alcoholic fatty liver disease [4,[8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women

Murata-Mori

Hayashida

Ando

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: The glucokinase regulator gene (GCKR) rs780094 has been shown to be strongly associated with some metabolic traits and atherosclerotic parameters, while the association between GCKR rs780094 and carotid intima-media thickness (CIMT) has not been fully investigated in the general population. The associations between the GCKR rs780094 genotype and metabolic traits including CIMT were examined in a Japanese community-dwelling population. Methods: A total of 2491 Japanese adults (907 men and 1584 women) who participated in a medical screening program for the general population from 29 to 94 years of age during 2008 to 2010 were enrolled. GCKR rs780094 was genotyped by the TaqMan polymerase chain reaction method, and associations with metabolic markers including CIMT were evaluated. Results: GCKR rs780094 AA genotype was significantly associated with higher TG (p < 0.001 vs. GG), lower HDL-C (p = 0.021 vs. GG), and lower HbA 1c (p = 0.023 vs. GG). The AA genotype showed significantly thinner CIMT (p = 0.001 vs. GX). These associations were seen only in men. Conclusions: GCKR rs780094 was associated with TG, HDL-C, and HbA 1c levels, as well as with CIMT in Japanese community-dwelling men, but not women.

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The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population

Cited by 63 publications

References 23 publications

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population

Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women

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