The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study

Karan, Radmila; Obrenović-Kirćanski, Biljana; Cvjetićanin, Suzana; Kovačević-Kostić, Nataša; Velinović, Miloš; Milicevic, Vladimir; Vranes-Stoimirov, Milica; Nikolić, Dejan

doi:10.3390/jcm7050103

Cited by 4 publications

(8 citation statements)

References 18 publications

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“…These findings coincide with the research of other authors indicating that a change in the degree of individual genetic homozygosity and variability may affect the predisposition to the occurrence of certain diseases [ 18 , 20 – 22 ].…”

Section: Discussionsupporting

confidence: 92%

“…The results of HRC test show a degree of genetic homozygosity as well as the level of possible genetic loads which may indicate the presence of genetic problems which further affect the capacity of normal development, with the possibility for more extreme cases of developing specific properties including increased or decreased resistance to certain types of illnesses [ 18 , 19 , 21 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

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Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study

Dimitrijević

Cvjetićanin

Pusica

et al. 2018

BioMed Research International

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Febrile seizures (FS) are the most common neurological disorder in childhood and are a great stress for parents due to their dramatic clinical appearance. Using test for determination of homozygously recessive characteristics in humans (HRC test) we analyzed presence, distribution, and individual combination of 20 selected genetically controlled morphophysiological traits among FS patients (N=121) and control (N=121) to determine a possible deviation in the homozygosity level and genetic loads in the group of affected children and whether there is a predisposition to the occurrence of FS. The results of our study show a statistically significant difference in the mean values of the HRC tested (x¯HRC/20 CN = 3.2 ± 0.2; x¯HRC/20 FS = 4.6 ± 0.2, t= 5.74 , p< 0.0001), as well as in the distribution and variability of two studied samples (VC=55,3%, VFS= 39,6%), which indicates a complex polygenic difference among the tested groups of subjects. The differences in the degree of genetic homozygosity and variability are also present between the genders (t Cf/FSf = 4.12; t Cm/FSm = 3.98; p <0.0001) (VCf=56.9%, VFSf= 39.3%; VCm=54.1%, VFSm=40.1%). Obtained results indicate the enlargement of recessively homozygous genetic loads in the group of children with FS which may represent some kind of predisposition for expressivity of this type of seizures.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study

Dimitrijević

Cvjetićanin

Pusica

et al. 2018

BioMed Research International

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“…These findings might justify the premise that genes determining the evaluated HRCs along with the environmental factors could potentially influence the development and easier expression of manifested ischemic stroke to a certain degree [ 16 ]. Our findings are in line with previous reports, which stated that hypertension has a multifactorial origin with both genetic and environmental factors contributing to different degrees [ 22 , 23 , 28 ]. Therefore, the increased degree of genetic homozygosity in the studied sample of stroke patients with hypertension compared to controls with hypertension implies that preferential phenotypes might exist, which could increase the susceptibility to the easier development of ischemic stroke.…”

Section: Discussionsupporting

confidence: 94%

Morphogenetic Variability and Hypertension in Ischemic Stroke Patients—Preliminary Study

Savić

Cvjetićanin

Lazović

et al. 2018

JCM

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In this study, we evaluated and compared the morphogenetic variability and the degree of recessive homozygosity in patients with manifested ischemic stroke compared to healthy controls. We have evaluated 120 patients with manifested ischemic stroke, of which 64 did not have hypertension and 56 have hypertension. For comparison, we additionally tested 194 healthy individuals without manifested ischemic stroke (controls). For the estimation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. There was a significant difference in the individual variations of 19 HRCs between the controls and patients with manifested ischemic stroke (∑χ2 = 60.162, p < 0.01). The mean values of the tested HRCs significantly differed between the controls and group with manifested ischemic stroke (Controls − 5.71 ± 1.61, Ischemic stroke group − 6.25 ± 1.54, p = 0.012). For the tested individuals with hypertension, the mean values of HRCs did not significantly differ between the controls and those that had manifested ischemic stroke (Controls − 5.28 ± 1.75, Ischemic stroke group − 5.64 ± 1.48, p = 0.435). We found a significant difference in the frequencies of HRCs between those with and without hypertension for controls (p < 0.003) and for those with manifested ischemic stroke (p < 0.001). There are increased degrees of recessive homozygosity along with decreased variability in patients with manifested ischemic stroke compared to controls.

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“…The HRC-test that has been developed by authors of Belgrade population genetics school is used to investigate the proportion of homozygously-recessive clearly-expressed traits in tested respondents as markers of chromosomal homozygosities, pointing to the degree of genetic homozygosity in humans (MARINKOVIC et al, 2008;NIKOLIC et al, 2012a;MARINKOVIC et al, 1994;MARINKOVIC and CVJETICANIN, 2013). Such test could be considered as a method for estimating the individual homozygosity and is done by the direct observation of defined phenotype traits (MARINKOVIC et al, 2008;NIKOLIC et al, 2012a;MARINKOVIC et al, 1994;MARINKOVIC and CVJETICANIN, 2013;NIKOLIC et al, 2010;MILAŠINOVIĆ et al, 2017;NIKOLIC et al, 2012b;KARAN et al, 2018;SAVIC et al, 2018;PETRICEVIC and CVJETICANIN, 2011;CVJETICANIN and MARINKOVIC, 2009;CVJETIĆANIN, 2009). To preserve the same objectivity and equal criteria for estimation of HRCs presence, one person performed the testing on both studied population samples.…”

Section: Study Methodsmentioning

confidence: 99%

Genetic homozygosity as a marker of smoking dependency

Brankovic¹,

Nikolić

Marinković

et al. 2020

Genetika

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The aim of our study was to evaluate the morphogenetic variability as a marker of smoking dependency in adult smokers versus controls and to investigate the presence and the degree of morphogenetic variability difference between male and female smokers versus same gender controls. The cross-sectional study evaluated 241 smokers and 185 nonsmoker individuals as controls. We analyzed 17 homozygous recessive characteristics (HRC). There was a significant difference in the individual variations of 17 HRCs between the controls and smokers (??2=61.400, p<0.001; for females ??2=79.440, p<0.001; for males ??2=84.972, p<0.001). The mean values of HRCs significantly differed between smokers and controls (MV?SEM(Controls) -4.79?0.13, MV?SEM(Smokers) -5.70?0.12; p<0.001). For males, presence of 6/17 (35.29% genetic homozygosity) HRCs (OR=6.12) was to the certain degree predictor for smoking dependency. Higher degree of genetic homozygosity, changed variability and male gender, might be some among potential numerous factors that could have impact on smoking development and dependence.

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The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study

Cited by 4 publications

References 18 publications

Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study

Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study

Morphogenetic Variability and Hypertension in Ischemic Stroke Patients—Preliminary Study

Genetic homozygosity as a marker of smoking dependency

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