The Gene Downstream of the gC Homologue in Feline Herpes Virus Type 1 is Involved in the Expression of Virulence

Willemse, M. J.; Chalmers, W. S. K.; Cronenberg, A. M.; Pfundt, Rolph; Strijdveen, I. G. L.; Sondermeijer, P. J. A.

doi:10.1099/0022-1317-75-11-3107

Cited by 35 publications

(19 citation statements)

References 32 publications

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“…Thus recombinant poxviruses and baculoviruses have been constructed expressing the FeHV-1 glycoprotein D to characterize its properties and potential as an immunogen [77,120]. A number of FeHV-1 deletion/insertional mutants have been developed including thymidine kinase deletion mutants, some of which have incorporated other genes including the FCV capsid gene [12,88,89,144,[156][157][158][159]; gE-gI deletion mutants [68,129,130]; a gI insertional mutant (which also appeared to affect the transcription pattern and expression of the upstream gene gD) [150,151]; and an insertional mutant of 'ORF2', downstream of glycoprotein C [149]. In general, these deletion/insertional mutants are less virulent for cats and offer some protection against disease, especially via the oro-nasal route.…”

Section: Vaccinationmentioning

confidence: 99%

Feline herpesvirus

et al. 2007

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Section: Vaccinationmentioning

confidence: 99%

Feline herpesvirus

et al. 2007

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“…13 PCR was carried out using 2e5 units of Taq DNA polymerase (Biolabs, Leusden, The Netherlands) and 5 ml of DNA template, annealing performed at 59 C for 1 min. Negative controls were performed in each test by adding water and supernatant of uninfected CrFK cells in the place of the nucleic acid template.…”

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confidence: 99%

Feline herpesvirus 1 and feline calicivirus infections in a heterogeneous cat population of a rescue shelter

Zicola

Saegerman

Quatpers

et al. 2009

Journal of Feline Medicine and Surgery

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Feline herpesvirus 1 (FeHV-1) and feline calicivirus (FCV), associated with upper respiratory tract disease, are highly prevalent in cats worldwide. With the aim to investigate the importance of feline respiratory viruses in a heterogeneous population of cats, samples were taken in a rescue shelter in Liège, Belgium, between March 2005 and August 2006. Reverse transcription polymerase chain reaction (RT-PCR) and polymerase chain reaction (PCR) were performed to diagnose FCV and FeHV-1 infection in the sampled cats. The prevalence rate (33.1%) was higher for FCV than for FeHV-1 (20.1%) whereas prevalence rate of co-infection with both viruses was 10%. Gingivitis was more common in FCV infections (odds ratio (OR) ¼ 2.83) whereas respiratory signs were more often observed with FeHV-1 infections. The average age was significantly higher in FCV positive cats (38 months) than in FeHV-1 positive cats (29.9 months). The second and the fourth quarters of the year and the two first quarters were significantly more at risk than the others in the case of FeHV-1 and FCV infection, respectively. Age was found to be a confounding factor. High prevalence of both infections strengthens the importance of applying hygienic and preventive measures in rescue shelters where cats with an unknown status of vaccination are introduced.

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“…2) FHV-1 ORF2 gene downstream of the gC Willemse et al [124] identified a novel virulence factor in the unique long (UL) region of the FHV-1 genome. This locus is the positional homologue of HSV-1 UL45 and is located downstream of the gene encoding FHV-1 gC.…”

Section: ) Fhv-1 Tk Genementioning

confidence: 99%

“…LacZ expression cassette is available for identification of virulence genes of FHV-1 [106,[124][125][126]. The expression cassette can be inserted at a specific region, which is nonessential for virus propagation, in subfragments of the FHV-1 genome.…”

Section: Genetically Engineered Fhv-1 Vaccinesmentioning

confidence: 99%

Recombinant Viral Vector Vaccines for the Veterinary Use.

Yokoyama

Maeda

Mikami

1997

The Journal of Veterinary Medical Science

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ABSTRACT. Recently, genetically engineering using recombinant DNA techniques has been applied to design new viral vaccines in order to reduce some problems which present viral vaccines have. Up to now, many viruses have been investigated for development of recombinant attenuated vaccines or live viral vectors for delivery of foreign immunogenic antigens. In this review, we introduced three kind of viruses; herpesviruses, vaccinia viruses, and adenoviruses, which have best widely been studied as recombinant vaccines or delivery vaccines for the veterinary use. -KEY WORDS: recombinant polyvalent vaccine, recombinant vaccine, viral vector.

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The Gene Downstream of the gC Homologue in Feline Herpes Virus Type 1 is Involved in the Expression of Virulence

Cited by 35 publications

References 32 publications

Feline herpesvirus

Feline herpesvirus

Feline herpesvirus 1 and feline calicivirus infections in a heterogeneous cat population of a rescue shelter

Recombinant Viral Vector Vaccines for the Veterinary Use.

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