The gene encoding glutathione‐dependent formaldehyde dehydrogenase/GSNO reductase is responsive to wounding, jasmonic acid and salicylic acid

Dı́az, Maykelis; Achkor, Hakima; Titarenko, Elena; Martínez, Manuela

doi:10.1016/s0014-5793(03)00426-5

Cited by 136 publications

(32 citation statements)

References 36 publications

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“…Formaldehyde dehydrogenase catalyzes the conversion of HM-GSH to formylglutathione, and then s-formylglutathione hydrolase catalyzes the conversion of formylglutathione to formate and glutathione [47]- [50] [61].…”

Section: Formaldehyde Detoxificationmentioning

confidence: 99%

Discovery of Key Molecular Pathways of C1 Metabolism and Formaldehyde Detoxification in Maize through a Systematic Bioinformatics Literature Review

Deonikar¹,

Kothandaram²,

Mohan³

et al. 2015

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Computational systems biology approaches provide insights to understand complex molecular phenomena in living systems. Such understanding demands the need to systematically interrogate and review existing literature to refine and distil key molecular pathways. This paper explores a methodological process to identify key molecular pathways from systematic bioinformatics literature review. This process is used to identify molecular pathways for a ubiquitous molecular process in all plant biological systems: C1 metabolism and formaldehyde detoxification, specific to maize. The C1 metabolism is essential for all organisms to provide one-carbon units for methylation and other types of modifications, as well as for nucleic acid, amino acid, and other biomolecule syntheses. Formaldehyde is a toxic one-carbon molecule which is produced endogenously and found in the environment, and whose detoxification is an important part of C1 metabolism. This systematic review involves a five-part process: 1) framing of the research question; 2) literature collection based on a parallel search strategy; 3) relevant study selection based on search refinement; 4) molecular pathway identification; and 5) integration of key molecular pathway mechanisms to yield a well-defined set molecular systems associated with a particular biochemical function. Findings from this systematic review produced three main molecular systems: a) methionine biosynthesis; b) the methylation cycle; and c) formaldehyde detoxification. Specific insights from the resulting molecular pathways indicate that normal C1 metabolism involves the transfer of a * Corresponding author. P. Deonikar et al.572 carbon group from serine through a folate-mediated pathway to methionine, and eventually the methylation of a biomolecule. In photosynthetic tissues, C1 metabolism often proceeds in reverse towards serine biosynthesis and formate oxidation. C1 metabolism, in maize, appears to be present in the developing embryo and endosperm indicating that these cells are vulnerable to perturbations in formaldehyde detoxification. These insights demonstrate the value of a systematic bioinformatics literature review process from a broad spectrum of domain literature to specific and relevant molecular pathways.

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Section: Formaldehyde Detoxificationmentioning

confidence: 99%

Discovery of Key Molecular Pathways of C1 Metabolism and Formaldehyde Detoxification in Maize through a Systematic Bioinformatics Literature Review

Deonikar¹,

Kothandaram²,

Mohan³

et al. 2015

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“…The primary role of formaldehyde dehydrogenase (up-regulated gene in the copper exposures) is the metabolism of formaldehyde. This enzyme may be indirectly involved in oxidative stress since alternative substrates for formaldehyde dehydrogenase can be toxic aldehydic fatty acid derivatives that are formed during the degradation of lipid membranes in a situation of oxidative stress (Dı́az et al, 2003;Singh et al, 2013).…”

Section: Oxidative Stressmentioning

confidence: 99%

Gene transcription patterns and energy reserves in Daphnia magna show no nanoparticle specific toxicity when exposed to ZnO and CuO nanoparticles.

Adam

Vergauwen

Blust

et al. 2015

Environmental Research

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There is still a lot of contradiction on whether metal ions are solely responsible for the observed toxicity of ZnO and CuO nanoparticles to aquatic species. While most experiments have studied nanoparticle effects at organismal levels (e.g. mortality, reproduction), effects at lower levels of biological organization may clarify the role of metal ions, nanoparticles and nanoparticle aggregates. In this study, the effect of ZnO and CuO nanoparticles was tested at two lower levels: energy reserves and gene transcription and compared with zinc and copper salts. Daphnia magna was exposed during 96h to 10% immobilization concentrations of all chemicals, after which daphnids were sampled for determination of glycogen, lipid and protein concentration and for a differential gene transcription analysis using microarray. The dissolved, nanoparticle and aggregated fraction in the medium was characterized. The results showed that ZnO nanoparticles had largely dissolved directly after addition to the test medium. The CuO nanoparticles mostly formed aggregates, while only a small fraction dissolved. The exposure to zinc (both nano and metal salt) had no effect on the available energy reserves. However, in the copper exposure, the glycogen, lipid and protein concentration in the exposed daphnids was lower than in the unexposed ones. When comparing the nanoparticle (ZnO or CuO) exposed daphnids to the metal salt (zinc or copper salt) exposed daphnids, the microarray results showed no significantly differentially transcribed gene fragments. The results indicate that under the current exposure conditions the toxicity of ZnO and CuO nanoparticles to D. magna is solely caused by toxic metal ions.

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“…Among other possibilities of note is the reaction catalyzed by S -nitrosoglutathione (GSNO) reductase (Figure 1), which can produce GSSG from GSH and GSNO. Although this enzyme is receiving considerable attention for its role in various physiological functions (Sakamoto et al, 2002; Díaz et al, 2003; Barroso et al, 2006; Kwon et al, 2012), its capacity relative to enzymes such as DHAR is unclear. Adenosine phosphosulfate reductase (APR), a key chloroplastic enzyme in sulphate reduction, uses GSH as electron donor (Bick et al, 1998).…”

Section: Candidate Pathwaysmentioning

confidence: 99%

Missing links in understanding redox signaling via thiol/disulfide modulation: how is glutathione oxidized in plants?

et al. 2013

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Glutathione is a small redox-active molecule existing in two main stable forms: the thiol (GSH) and the disulphide (GSSG). In plants growing in optimal conditions, the GSH:GSSG ratio is high in most cell compartments. Challenging environmental conditions are known to alter this ratio, notably by inducing the accumulation of GSSG, an effect that may be influential in the perception or transduction of stress signals. Despite the potential importance of glutathione status in redox signaling, the reactions responsible for the oxidation of GSH to GSSG have not been clearly identified. Most attention has focused on the ascorbate-glutathione pathway, but several other candidate pathways may couple the availability of oxidants such as H2O2 to changes in glutathione and thus impact on signaling pathways through regulation of protein thiol-disulfide status. We provide an overview of the main candidate pathways and discuss the available biochemical, transcriptomic, and genetic evidence relating to each. Our analysis emphasizes how much is still to be elucidated on this question, which is likely important for a full understanding of how stress-related redox regulation might impinge on phytohormone-related and other signaling pathways in plants.

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The gene encoding glutathione‐dependent formaldehyde dehydrogenase/GSNO reductase is responsive to wounding, jasmonic acid and salicylic acid

Cited by 136 publications

References 36 publications

Discovery of Key Molecular Pathways of C1 Metabolism and Formaldehyde Detoxification in Maize through a Systematic Bioinformatics Literature Review

Discovery of Key Molecular Pathways of C1 Metabolism and Formaldehyde Detoxification in Maize through a Systematic Bioinformatics Literature Review

Gene transcription patterns and energy reserves in Daphnia magna show no nanoparticle specific toxicity when exposed to ZnO and CuO nanoparticles.

Missing links in understanding redox signaling via thiol/disulfide modulation: how is glutathione oxidized in plants?

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