The Gene Polymorphism of IL-17 G-152A is Associated with Increased Colonization of Streptococcus pneumoniae in Young Finnish Children

Vuononvirta, Juho; Peltola, Ville; Ilonen, Jorma; Mertsola, Jussi; He, Qiushui

doi:10.1097/inf.0000000000000691

Cited by 21 publications

(22 citation statements)

References 26 publications

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“…Furthermore, patients with autosomal dominant hyper-IgE syndrome (Job's syndrome), who lack the ability to generate memory Th17 cells due to mutations in the STAT3 gene, are highly susceptible to recurrent pneumococcal infections (9,10). More recently, two studies provided support for a role of IL-17A in pneumococcal carriage in children: a specific polymorphism of the IL-17 gene (G152A) in Finnish children (11) and decreased IL-17A secretion in Fijian children (12) were associated with increased risks of pneumococcal carriage.…”

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confidence: 99%

Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses

Oliver

Zhang

et al. 2018

Infect Immun

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Conjugate vaccines against have significantly reduced diseases caused by serotypes included in those vaccines; however, there is still need for vaccines that confer serotype-independent protection. In the current study, we have constructed a library of conserved surface proteins from and screened for IL-17A and IL-22 production in human immune cells obtained from adenoidal/tonsillar tissue of children and IL-17A production from splenocytes from mice that were immunized with a killed whole cell vaccine or previously exposed to pneumococcus. A positive correlation was found between rankings of proteins from human IL-17A and IL-22 screens, but not between human and mouse screens. All proteins were tested for protection against colonization, from which we identified protective antigens that are IL-17A dependent. We found that the likelihood of finding a protective antigen is significantly higher from groups of proteins ranked in the top 50% of all three screens than for groups of proteins ranked in the bottom 50% of all three. The results thus confirmed the value of such screens to identify Th17 antigens. Further, these experiments have evaluated and compared the breadth of human and mouse Th17 responses to pneumococcal colonization and enabled the identification of potential vaccine candidates based on immunological responses in mouse and human cells.

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confidence: 99%

Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses

Oliver

Zhang

et al. 2018

Infect Immun

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“…Our observations differed from the findings of a Finnish study that measured serum IL-17A in 93 of the 405 controls included in the present study at 13 months of age. That study found that IL-17A was detectable in 6% of the variant AA homozygotes, in 33% of the variant GA heterozygotes and in 75% of the wild GG homozygotes (12). The concentrations were much higher in the adults in the present study: the median was 26.3 pg/mL in those with the variant genotype and 28.94 pg/mL in those with the wild genotype, compared to <1.25 pg/mL and 2.5 pg/mL in the infant controls, respectively (12).…”

Section: Discussionmentioning

confidence: 92%

“…That study found that IL-17A was detectable in 6% of the variant AA homozygotes, in 33% of the variant GA heterozygotes and in 75% of the wild GG homozygotes (12). The concentrations were much higher in the adults in the present study: the median was 26.3 pg/mL in those with the variant genotype and 28.94 pg/mL in those with the wild genotype, compared to <1.25 pg/mL and 2.5 pg/mL in the infant controls, respectively (12). The measurements were carried out with the same method in the same laboratory, which means that the differences were not technical.…”

Section: Discussionmentioning

confidence: 92%

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Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette‐Guérin vaccination

Liehu-Martiskainen¹,

Korppi²,

Teräsjärvi

et al. 2017

Acta Paediatrica

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“…Similarly to the other cytokines mentioned above, gene polymorphism has been observed in IL-17, IL-23, and the IL-23 receptor. Previously, IL-17 polymorphism has been associated with increased bacterial colonization and childhood asthma (Chen et al 2010;Vuononvirta et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults

Gröndahl-Yli-Hannuksela

Vahlberg

Ilonen

et al. 2016

Immunogenetics

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Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-12B (rs2546890), IL-12RB1 (rs372889), IL-17A (rs2275913), and IL-23R (rs11209026) affect the immune responses after acellular pertussis vaccination. The T cell proliferative response was evaluated in 38 Finnish young adults who received a second booster dose of a vaccine combination of diphtheria, tetanus, and acellular pertussis, 10 years after the previous booster. The response was evaluated with a proliferation assay in which vaccine antigens pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (PRN) were used for the stimulation, before and 1 month after the second vaccination. Specific proliferation of peripheral blood mononuclear cells against pertussis antigens was affected by IL-10 SNP in the promoter region at position -1082 (A>G, rs1800896). One month after the vaccination, subjects with the AA and AG genotypes had a significantly higher T cell proliferative response against PT and FHA compared to those with the GG genotype. Subjects with the GG genotype had the lowest responses. As a conclusion, our preliminary results indicate that IL-10 SNP -1082 might play an important role in T cell-mediated immune responses after acellular pertussis vaccination.

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The Gene Polymorphism of IL-17 G-152A is Associated with Increased Colonization of Streptococcus pneumoniae in Young Finnish Children

Abstract: Our results indicate that IL-17 G-152A is associated with increased colonization rate of S. pneumoniae in young children, suggesting that IL-17A plays an important role in protection against pneumococcal colonization.

Cited by 21 publications

References 26 publications

Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses

Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses

Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette‐Guérin vaccination

Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults

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